A gravitationally lensed quasar with quadruple images separated by 14.62 arcseconds

Gravitational lensing is a powerful tool for the study of the distribution of dark matter in the Universe. The cold-dark-matter model of the formation of large-scale structures (that is, clusters of galaxies and even larger assemblies) predicts the existence of quasars gravitationally lensed by concentrations of dark matter so massive that the quasar images would be split by over 7 arcsec. Numerous searches for large-separation lensed quasars have, however, been unsuccessful. All of the roughly 70 lensed quasars known, including the first lensed quasar discovered, have smaller separations that can be explained in terms of galaxy-scale concentrations of baryonic matter. Although gravitationally lensed galaxies with large separations are known, quasars are more useful cosmological probes because of the simplicity of the resulting lens systems. Here we report the discovery of a lensed quasar, SDSS J1004 + 4112, which has a maximum separation between the components of 14.62 arcsec. Such a large separation means that the lensing object must be dominated by dark matter. Our results are fully consistent with theoretical expectations based on the cold-dark-matter model.     

The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin

Insulin stimulates glucose transport by promoting exocytosis of the glucose transporter Glut4 (refs 1, 2). The dynamic processes involved in the trafficking of Glut4-containing vesicles, and in their targeting, docking and fusion at the plasma membrane, as well as the signalling processes that govern these events, are not well understood. We recently described tyrosine-phosphorylation events restricted to subdomains of the plasma membrane that result in activation of the G protein TC10 (refs 3, 4). Here we show that TC10 interacts with one of the components of the exocyst complex, Exo70. Exo70 translocates to the plasma membrane in response to insulin through the activation of TC10, where it assembles a multiprotein complex that includes Sec6 and Sec8. Overexpression of an Exo70 mutant blocked insulin-stimulated glucose uptake, but not the trafficking of Glut4 to the plasma membrane. However, this mutant did block the extracellular exposure of the Glut4 protein. So, the exocyst might have a crucial role in the targeting of the Glut4 vesicle to the plasma membrane, perhaps directing the vesicle to the precise site of fusion.     

Three-dimensional structural dynamics of myosin V by single-molecule fluorescence polarization

The structural change that generates force and motion in actomyosin motility has been proposed to be tilting of the myosin light chain domain, which serves as a lever arm. Several experimental approaches have provided support for the lever arm hypothesis; however, the extent and timing of tilting motions are not well defined in the motor protein complex of functioning actomyosin. Here we report three-dimensional measurements of the structural dynamics of the light chain domain of brain myosin V using a single-molecule fluorescence polarization technique that determines the orientation of individual protein domains with 20-40-ms time resolution. Single fluorescent calmodulin light chains tilted back and forth between two well-defined angles as the myosin molecule processively translocated along actin. The results provide evidence for lever arm rotation of the calmodulin-binding domain in myosin V, and support a 'hand-over-hand' mechanism for the translocation of double-headed myosin V molecules along actin filaments. The technique is applicable to the study of real-time structural changes in other biological systems.     

Summer food habits of coyotes in central Wyoming

Summer food habits of coyotes ( Canis latrans ) were investigated on a 3100-km 2 area in central Wyoming, divided into one deer-use area and five non-deer areas. Analysis of 404 scats (fecal samples) revealed an overall average of 63 percent occurrence of native ungulates, 63 percent leporids, 46 percent rodents, 14 percent livestock, and 11 percent birds. Pronghorn ( Antilocapra Americana ) was the ungulate most frequently consumed, occurring in about 87 percent of the scats. Mule deer ( Odocoileus hemionus ) occurred in only 8 percent, and in 5 percent the native ungulate remains were not identifiable beyond order. This large percentage of big game in the diet is apparently unusual, because big game has been of minor importance in most coyote food-habit studies. The high incidence of leporids is consistent with other studies performed in arid intermountain areas. Although cricetines, especially deer mice ( Peromyscus maniculatus ), were trapped consistently in all habitats, months, and trapping areas, they were found in scats at a lower frequency than microtines and sciurids. This suggests a coyote hunting strategy that selected for the latter two groups.     

Aspects of Quantum Non-Locality II: Superluminal Causation and Relativity

In a preceding paper, I studied the significance of Jarrett's and Shimony's analyses of ‘factorisability’ into ‘parameter independence’ and ‘outcome independence’ for clarifying the nature of non-locality in quantum phenomena. I focused on four types of non-locality; superluminal signalling, action-at-a-distance, non-separability and holism. In this paper, I consider a fifth type of non-locality: superluminal causation according to ‘logically weak’ concepts of causation, where causal dependence requires neither action nor signalling. I conclude by considering the compatibility of non-factorisable theories with relativity theory. In this connection, I pay special attention to the difficulties that superluminal causation raises in relativistic spacetime. My main findings in this paper are: first, parameter-dependent and outcome-dependent theories both involve superluminal causal connections between outcomes and between settings and outcomes. Second, while relativistic deterministic parameter-dependent theories seem impossible on pain of causal paradoxes, relativistic indeterministic parameter-dependent theories are not subjected to the same challenge. Third, current relativistic non-factorisable theories seem to have some rather unattractive characteristics.     

ATM网络中输出过程的自相似特性

建立一个有限缓冲区的单服务器模型，证明了在队长有有限二阶矩的条件下，输出过程具强渐近二阶自相似性质与输出过程具强渐近二阶自相似性质等价。     

高分子物理概论

高分子概念的形成和高分子科学的出现始于20世纪20年代。当时有些有机化学家开展了缩聚反应及其自由基聚合反应的研究，并通过这些反应相继开发出尼龙（聚酰胺）66、氯丁橡胶、丁苯橡胶和聚甲基丙烯酸甲酯等一大批高分子材料，从而形成了“高分子化学”的研究领域。随着这些合成高分子的出现，解决这些高分子的性能和表征：以及了解其结构对性能的影响等问题也随之变得很必要了。因此从20世纪40年代至50年代，一批化学家、物理学家投入这方面的研究，渐渐形成了“高分子物理”这门新兴的学科。