全文获取类型
收费全文 | 11732篇 |
免费 | 45篇 |
国内免费 | 72篇 |
专业分类
系统科学 | 61篇 |
丛书文集 | 29篇 |
教育与普及 | 21篇 |
理论与方法论 | 32篇 |
现状及发展 | 5448篇 |
研究方法 | 594篇 |
综合类 | 5534篇 |
自然研究 | 130篇 |
出版年
2012年 | 207篇 |
2011年 | 306篇 |
2010年 | 78篇 |
2009年 | 74篇 |
2008年 | 204篇 |
2007年 | 244篇 |
2006年 | 253篇 |
2005年 | 239篇 |
2004年 | 210篇 |
2003年 | 197篇 |
2002年 | 249篇 |
2001年 | 438篇 |
2000年 | 430篇 |
1999年 | 290篇 |
1992年 | 239篇 |
1991年 | 196篇 |
1990年 | 217篇 |
1989年 | 193篇 |
1988年 | 204篇 |
1987年 | 221篇 |
1986年 | 191篇 |
1985年 | 256篇 |
1984年 | 231篇 |
1983年 | 171篇 |
1982年 | 176篇 |
1981年 | 180篇 |
1980年 | 171篇 |
1979年 | 407篇 |
1978年 | 343篇 |
1977年 | 251篇 |
1976年 | 290篇 |
1975年 | 261篇 |
1974年 | 272篇 |
1973年 | 226篇 |
1972年 | 245篇 |
1971年 | 309篇 |
1970年 | 376篇 |
1969年 | 256篇 |
1968年 | 312篇 |
1967年 | 294篇 |
1966年 | 254篇 |
1965年 | 179篇 |
1964年 | 99篇 |
1959年 | 88篇 |
1958年 | 162篇 |
1957年 | 100篇 |
1956年 | 91篇 |
1955年 | 85篇 |
1954年 | 77篇 |
1948年 | 64篇 |
排序方式: 共有10000条查询结果,搜索用时 375 毫秒
211.
Receptor communication within the lymphocyte plasma membrane: a role for the thrombospondin family of matricellular proteins 总被引:1,自引:0,他引:1
Lymphocytes, the principal cells of the immune system, carry out immune surveillance throughout the body by their unique capacity
to constantly reposition themselves between a free-floating vascular state and a tissue state characterized by migration and
frequent adhesive interactions with endothelial cells and components of the extracellular matrix. Therefore, mechanisms co-ordinating
adhesion and migration with signals delivered through antigen recognition probably play a pivotal role for the regulation
of lymphocyte behaviour and function. Endogenous thrombospondin-1 (TSP-1) seems to be the hub in such a mechanism for autocrine
regulation of T cell adhesion and migration. TSP-1 functions as a mediator of cis interaction of vital receptors within the T lymphocyte plasma membrane, including integrins, low density lipoprotein receptor-related
protein, calreticulin and integrin-associated protein.
Received 1 June 2006; received after revision 28 June 2006; accepted 11 October 2006 相似文献
212.
213.
Genetic studies of diseases 总被引:1,自引:0,他引:1
The biological system is a complex physicochemical system consisting of numerous dynamic networks of biochemical reactions and signaling interactions between cellular components. This complexity makes it virtually unanalyzable by traditional methods. Hence, biological networks have been developed as a platform for integrating information from high- to low-throughput experiments for analysis of biological systems. The network analysis approach is vital for successful quantitative modeling of biological systems. The numerous online pathway databases vary widely in coverage and representation of biological processes. An integrated network-based information system for querying, visualization and analysis promised successful integration of data on a large scale. Such integrated systems will greatly facilitate the understanding of biological interactions and experimental verification. 相似文献
214.
Lindahl E Nyman U Melles E Sigmundsson K Ståhlberg M Wahren J Obrink B Shafqat J Joseph B Jörnvall H 《Cellular and molecular life sciences : CMLS》2007,64(4):479-486
Proinsulin C-peptide is known to bind specifically to cell membranes and to exert intracellular effects, but whether it is
internalized in target cells is unknown. In this study, using confocal microscopy and immunostained or rhodamine-labeled peptide,
we show that C-peptide is internalized and localized to the cytosol of Swiss 3T3 and HEK-293 cells. In addition, transport
into nuclei was found using the labeled peptide. The internalization was followed at 37°C for up to 1 h, and was reduced at
4°C and after preincubation with pertussis toxin. Hence, it is concluded to occur via an energy-dependent, pertussis toxin-sensitive
mechanism and without detectable degradation within the experimental time course. Surface plasmon resonance measurements demonstrated
binding of HEK-293 cell extract components to C-peptide, and subsequent elution of bound material revealed the components
to be intracellular proteins. The identification of C-peptide cellular internalization, intracellular binding proteins, absence
of rapid subsequent C-peptide degradation and apparent nuclear internalization support a maintained activity similar to that
of an intracrine peptide hormone. Hence, the data suggest the possibility of one further C-peptide site of action.
Received 31 October 2006; received after revision 27 December 2006; accepted 30 December 2006 相似文献
215.
Beyond their role in replication and chromosome end capping, telomeres are also thought to function in meiotic chromosome pairing, meiotic and mitotic chromosome segregation as well as in nuclear organization. Observations in both somatic and meiotic cells suggest that the positioning of telomeres within the nucleus is highly specific and believed to be dependent mainly on telomere interactions with the nuclear envelope either directly or through chromatin interacting proteins. Although little is known about the mechanism of telomere clustering, some studies show that it is an active process. Recent data have suggested a regulatory role for telomere chromatin structure in telomere movement. This review will summarize recent studies on telomere interactions with the nuclear matrix, telomere chromatin structure and factors that modify telomere chromatin structure as related to regulation of telomere movement. 相似文献
216.
Jonathan Mawdsley James Harrison Hendrik Sithole 《Journal of Natural History》2016,50(45-46):2849-2879
We describe activity patterns, relative abundances and pollen transport by insect floral visitors in the Skukuza Ranger District, Kruger National Park, Republic of South Africa, based on field surveys conducted during the early rainy seasons of years 2006 to 2012 (inclusive). Diagnostic notes, illustrations and natural history observations are provided for species in the families Buprestidae, Cerambycidae, Cleridae, Lycidae and Scarabaeidae (Coleoptera), Muscidae, Platystomatidae and Tabanidae (Diptera), Apidae, Halictidae, Megachilidae, Sphecidae and Vespidae (Hymenoptera), and Pieridae and Thyrididae (Lepidoptera) that transported pollen of tree or shrub species. Observations on floral phenology and pollination syndrome are presented for 27 flowering tree or shrub species. To provide a foundation for studies of the effects of drought and climate change on pollination services in the Kruger National Park, we applied methods of food web analysis to characterise this plant-pollinator assemblage. The food web analysis shows moderate levels of redundancy in plant-pollinator interactions (with connectance values averaging 0.19 for plant species and 0.20 for pollinator species), suggesting that pollination services in this system may exhibit some resilience to environmental perturbations. Possible conservation strategies for maintaining pollination services in this ecological system are discussed, including habitat management to conserve larval or nesting areas for social and solitary bees and scarab beetles, as well as further inventories and long-term monitoring of pollinator species. 相似文献
217.
218.
219.
Martha M. Muñoz Kristen E. Crandell Shane C. Campbell-Staton Kristi Fenstermacher Hannah K. Frank Paul Van Middlesworth 《Journal of Natural History》2015,49(27-28):1717-1730
Aquatic anoles present an interesting ecomorphological puzzle. On the one hand, the link between habitat use and morphology is well established as convergent within the Caribbean anole radiation. On the other hand, aquatic anoles do not appear to form an ecomorphological group – rather, it appears that there may be several ways to adapt to aquatic habitats. We explore this issue by examining the ecology, morphology and performance of four species of Central American aquatic anoles belonging to two different lineages. Overall, we find that aquatic anoles overlap in multiple ecological and morphological dimensions. However, we do find some differences in substrate use, claw and limb morphology, and bite force that distinguish Anolis aquaticus from the other three species (A. lionotus, A. oxylophus and A. poecilopus). Our results suggest that A. aquaticus is adapted to climb on boulders, whereas the other species utilise vegetation in streamside habitats. 相似文献
220.
Parasites of the grey mullet Mugil cephalus collected from Lower K?z?l?rmak Delta in Turkey were investigated. Trichodina puytoraci, Trichodina lepsii, Ligophorus mediterraneus, Ligophorus cephali, Gyrodactylus sp., Microcotyle mugilis, Ascocotyle (Phagicola) longa, Haplosplanchnus pachysomus, Diplostomum spathaceum, Tylodelphys clavata, Posthodiplostomum sp., Neoechinorhyncus agilis and Ergasilus lizae were identified. Overall infection prevalence (%), mean intensity and mean abundance values were 99.61%, 458.10 ± 75.72 and 456.30 ± 75.44, respectively. Infection indices of parasite species in relation to season, lakes/lagoons and some physicochemical parameters of water such as temperature, salinity, dissolved oxygen and nitrate are determined and discussed. Posthodiplostomum sp. is a new parasite record for mugilids and Diplostomum spathaceum is the first record in M. cephalus, in the present study. Moreover, Ligophorus mediterraneus, Ligophorus cephali and Ergasilus lizae are new records for Turkish parasite fauna of fish and Mugil cephalus is a new host record for Neoechinorhyncus agilis in Turkey. 相似文献