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931.
It is common knowledge that our feelings of alertness or drowsiness vary throughout the day. Indeed, this diurnal variation is so widely accepted that it has been used to validate the drowsy/alert component of activation obtained from mood adjective checklists. There is, however, some evidence from sleep deprivation and shiftwork studies that this variation is not simply a reflection of our sleep/wake cycle, as might be expected, but is at least partially dependent on an endogenous circadian (approximately 24 h) oscillator such as that proposed to account for the circadian rhythm in body temperature and other physiological variables. Here we have tested this suggestion by separating the body-temperature rhythm from the sleep/wake cycle by progressively shortening artificial time cues (zeitgebers). Our results indicate that the circadian rhythm in alertness can become independent of both the sleep/wake cycle and the rhythm in body temperature. Further, and contrary to our expectations, the results suggest that the sleep/wake cycle exerts less influence on the alertness rhythm than it does on that of temperature. 相似文献
932.
Summary An enzyme responsible for synthesizing carthamin from precarthamin was partially purified and the catalytic properties were investigated.Acknowledgments. The authors wish to thank Prof. A. Komamine, University of Tokyo, for reading this paper. We are indebted to Prof. A. Saito, Tokai University, for performing emission spectrochemical analysis of the enzyme protein used in this study. 相似文献
933.
934.
Association of rheumatoid arthritis and primary osteoarthritis with changes in the glycosylation pattern of total serum IgG 总被引:19,自引:0,他引:19
R B Parekh R A Dwek B J Sutton D L Fernandes A Leung D Stanworth T W Rademacher T Mizuochi T Taniguchi K Matsuta 《Nature》1985,316(6027):452-457
Rheumatoid arthritis (RA) is a widely prevalent (1-3%) chronic systemic disease thought to have an autoimmune component; both humoral and cellular mechanisms have been implicated. Primary osteoarthritis (OA) is considered to be distinct from rheumatoid arthritis, and here damage is thought to be secondary to cartilage degeneration. In rheumatoid arthritis, immune complexes are present that consist exclusively of immunoglobulin, implying that this is both the 'antibody' (rheumatoid factor [RF]) and the 'antigen' (most commonly IgG). Autoantigenic reactivity has been localized to the constant-region (C gamma 2) domains of IgG. There is no evidence for a polypeptide determinant but carbohydrate changes have been reported. We have therefore conducted a study, simultaneously in Oxford and Tokyo, to compare in detail the N-glycosylation pattern of serum IgG (Fig. 1) isolated from normal individuals and from patients with either primary osteoarthritis or rheumatoid arthritis. The results, which required an evaluation of the primary sequences of approximately 1,400 oligosaccharides from 46 IgG samples, indicate that: (1) IgG isolated from normal individuals, patients with RA and patients with OA contains different distributions of asparagine-linked bi-antennary complex-type oligosaccharide structures, (2) in neither disease is the IgG associated with novel oligosaccharide structures, but the observed differences are due to changes in the relative extent of galactosylation compared with normal individuals. This change results in a 'shift' in the population of IgG molecules towards those carrying complex oligosaccharides, one or both of whose arms terminate in N-acetylglucosamine. These two arthritides may therefore be glycosylation diseases, reflecting changes in the intracellular processing, or post-secretory degradation of N-linked oligosaccharides. 相似文献
935.
The sponge Dysidea herbacea (Keller) was found to possess hemagglutinins. The major component, DHA-I, is a protein with a mol. wt of 26,000, which dissociates into subunits of equal size (14,000). It contains large amounts of glutamic acid and aspartic acid residues, but no half-cystine, methionine or histidine residues. DHA-I reacted with rabbit and human AB0 erythrocytes. D-galactose and lactose were effective inhibitors of DHA-I. The sponge also contained a minor component(s) which reacted preferentially with rabbit erythrocytes but not with human AB0 erythrocytes. 相似文献
936.
The effect of tributyltin (TBT) chloride on the growth of cytochrome-deficient and cytochrome-containing cells of Escherichia coli SASX76 was examined. The former cells were found to be at least 20 times more sensitive to TBT. It is proposed that the differential sensitivity of these two cell types to the biocide, TBT, may be due to a different mode of energy generation by cytochrome-deficient and cytochrome-sufficient cells. In addition to the energy state, the pH change caused by the presence and absence of cytochromes which occurred during growth also resulted in a differential sensitivity of these cells. 相似文献
937.
A highly polymorphic DNA marker linked to adult polycystic kidney disease on chromosome 16 总被引:27,自引:0,他引:27
S T Reeders M H Breuning K E Davies R D Nicholls A P Jarman D R Higgs P L Pearson D J Weatherall 《Nature》1985,317(6037):542-544
Adult polycystic kidney disease (APCKD) is a common and often lethal multi-organ disease with an autosomal dominant pattern of inheritance; approximately 1 in 1,000 people carry the mutant gene. The major pathological abnormality is the development and progressive enlargement of cysts in several organs including the liver, pancreas and spleen as well as the kidneys. The basic biochemical defect which leads to the formation of cysts remains unknown. Cyst development, which is not retarded by any known therapy, leads to irreversible renal failure and death at a mean age of 51 unless dialysis or transplantation are used. Patients with the disease account for 9% of chronic dialysis requirement. The first symptoms tend to occur in the fourth decade, after most patients have reproduced. Presymptomatic diagnosis depends on the ultrasonographic detection of cysts, but exclusion cannot be achieved by this means; 34% of at-risk patients in the second decade and 14% in the third will go on to develop cysts after negative diagnosis. The low sensitivity of diagnostic techniques in this critical age-range imposes severe limitations on genetic counselling and the condition cannot be identified prenatally. Hence we have searched for a linkage marker for APCKD; we show here that the APCKD locus is closely linked to the alpha-globin locus on the short arm of chromosome 16 (zeta = 25.85, theta = 0.05). 相似文献
938.
K. Hölzle 《Cellular and molecular life sciences : CMLS》1947,3(4):149-151
Summary It has been found that cyclisation of -halogenated -naphthalene-thioglycolic acids can occur in -position with the elimination of the halogen. The influence of the temperature and of a further substituent (halogen) in the second nucleus are discussed. 相似文献
939.
利用过氧化物过氧化二异丙苯(DCP)和多官能团化合物三烯丙基异氰尿酸酯(TAIC),对聚甲基乙撑碳酸酯(PPC)进行了交联研究。研究发现, DCP和TAIC的用量对PPC的交联均有较大影响, PPC交联后,其凝胶含量、机械性能、弹性模量、玻璃化转变温度均有所增加, 1%的DCP和4%的TAIC用量可得到较理想的交联PPC材料。 相似文献
940.