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61.
TONG Yongpeng ZHANG Guilin LI Yan HWU Yeukuang TSAI Wenli JE Jung Ho Margaritondo G YUAN Dong 《科学通报(英文版)》2005,50(22):2657-2661
Three human liver tissue samples (-5 mm × 40 mm × 20 mm) were excised from a cancer patient's liver during surgery. The microradiology analysis was performed with a non-standard approach on a synchrotron. High-resolution refractive-index edge-enhanced microradiographs that cover a larger volume of the liver tissue sample were obtained. The cancer tissue and normal tissue could be clearly identified and distinguished based on their different textures. Furthermore, new blood vessel hyperplasia was found near the cancer area. Blood vessels with a diameter smaller than 20 μm could be identified. These findings were fully consistent with the histopathological examination or the same area. Microradiographs of the newly formed blood vessels at different angles were also obtained. This result shows that it is possible to further develop this approach into a technique of microradiographic imaging for clinic diagnosis of liver cancer at the early stage. 相似文献
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64.
Rambabu Kuchi Monika Sharma Sung Woo Lee Dongsoo Kim Namgee Jung Jong-Ryul Jeong 《自然科学进展(英文版)》2019,29(1):88-93
Co@C core–shell nanospheres highly dispersed on carbon supports were rationally designed to improve the microwave absorbing property of the composite material, and fabricated by one pot thermal decomposition and simple annealing process. The Co nanospheres were completely encapsulated with thin carbon shells, which can effectively prevent the oxidation of the Co surface. Additionally, the particle size of Co nanospheres were properly controlled to optimize the electromagnetic property of the composite material. As a result, the lightweight Co@C/C composites with the particle size of 20 nm exhibited much enhanced microwave absorption properties. The improved microwave absorption performance is attributed mainly to the enhanced isotropic ratio and impedance matching of magnetic composites via tuning the Co particle size. Therefore, the welldesigned core-shell Co@C composite structure will provide a new insight for the development of high performance microwave absorbers. 相似文献
65.
Banerji S Cibulskis K Rangel-Escareno C Brown KK Carter SL Frederick AM Lawrence MS Sivachenko AY Sougnez C Zou L Cortes ML Fernandez-Lopez JC Peng S Ardlie KG Auclair D Bautista-Piña V Duke F Francis J Jung J Maffuz-Aziz A Onofrio RC Parkin M Pho NH Quintanar-Jurado V Ramos AH Rebollar-Vega R Rodriguez-Cuevas S Romero-Cordoba SL Schumacher SE Stransky N Thompson KM Uribe-Figueroa L Baselga J Beroukhim R Polyak K Sgroi DC Richardson AL Jimenez-Sanchez G Lander ES Gabriel SB Garraway LA Golub TR 《Nature》2012,486(7403):405-409
66.
吴光琳 《成都理工大学学报(自然科学版)》1996,(3)
该项研究是对声发射传感器联机探测岩石性质进行评价。首先探讨了声发射与岩石破碎机理的关系,然后介绍了把声发射传感器联接到锚杆孔钻机上,用反向传播神经网络“识别”岩石破碎特性和岩石种类。辨认岩石的准确度为99%。试验表明,神经网络的计算和校准能力能够使声发射传感器发挥更佳的探测作用。 相似文献
67.
Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. 总被引:161,自引:0,他引:161
The crystal structures of major histocompatibility complex (MHC) molecules contain a groove occupied by heterogeneous material thought to represent peptides central to immune recognition, although until now relatively little characterization of the peptides has been possible. Exact information about the contents of MHC grooves is now provided. Moreover, each MHC class I allele has its individual rules to which peptides presented in the groove adhere. 相似文献
68.
Reduced thermogenesis in obesity. 总被引:13,自引:0,他引:13
69.
Reductive evolution suggested from the complete genome sequence of a plant-pathogenic phytoplasma 总被引:20,自引:0,他引:20
Oshima K Kakizawa S Nishigawa H Jung HY Wei W Suzuki S Arashida R Nakata D Miyata S Ugaki M Namba S 《Nature genetics》2004,36(1):27-29
The minimal gene set essential for life has long been sought. We report the 860-kb genome of the obligate intracellular plant pathogen phytoplasma (Candidatus Phytoplasma asteris, OY strain). The phytoplasma genome encodes even fewer metabolic functions than do mycoplasma genomes. It lacks the pentose phosphate cycle and, more unexpectedly, ATP-synthase subunits, which are thought to be essential for life. This may be the result of reductive evolution as a consequence of life as an intracellular parasite in a nutrient-rich environment. 相似文献
70.
TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity 总被引:2,自引:0,他引:2
Gack MU Shin YC Joo CH Urano T Liang C Sun L Takeuchi O Akira S Chen Z Inoue S Jung JU 《Nature》2007,446(7138):916-920
Retinoic-acid-inducible gene-I (RIG-I; also called DDX58) is a cytosolic viral RNA receptor that interacts with MAVS (also called VISA, IPS-1 or Cardif) to induce type I interferon-mediated host protective innate immunity against viral infection. Furthermore, members of the tripartite motif (TRIM) protein family, which contain a cluster of a RING-finger domain, a B box/coiled-coil domain and a SPRY domain, are involved in various cellular processes, including cell proliferation and antiviral activity. Here we report that the amino-terminal caspase recruitment domains (CARDs) of RIG-I undergo robust ubiquitination induced by TRIM25 in mammalian cells. The carboxy-terminal SPRY domain of TRIM25 interacts with the N-terminal CARDs of RIG-I; this interaction effectively delivers the Lys 63-linked ubiquitin moiety to the N-terminal CARDs of RIG-I, resulting in a marked increase in RIG-I downstream signalling activity. The Lys 172 residue of RIG-I is critical for efficient TRIM25-mediated ubiquitination and for MAVS binding, as well as the ability of RIG-I to induce antiviral signal transduction. Furthermore, gene targeting demonstrates that TRIM25 is essential not only for RIG-I ubiquitination but also for RIG-I-mediated interferon- production and antiviral activity in response to RNA virus infection. Thus, we demonstrate that TRIM25 E3 ubiquitin ligase induces the Lys 63-linked ubiquitination of RIG-I, which is crucial for the cytosolic RIG-I signalling pathway to elicit host antiviral innate immunity. 相似文献