无侧移失稳模式下框架的稳定方程及框架柱的计算长度系数

对无侧移框架结构进行了弹性稳定分析，得到了理想状态下无侧移框架结构的稳定方程，并对r=0.6-1.0的理想情况下框架柱的计算长度系数计算的结果表明：在r=1.0时计算值与规范值符合非常好，虽然方程的成立依赖于较为理想的假定条件，不适于对实际结构进行计算，但仍可做为实际稳定分析的参考。     

Electrodeposited synthesis of self-supported Ni-P cathode for efficient electrocatalytic hydrogen generation

One of the key challenges for electrochemical water splitting is the development of low-cost and efficient hydrogen evolution cathode. In this work, a self-supported Ni-P cathode was synthesized by a facile electrodeposition method. The composition and morphology were characterized by X-ray diffraction, X-ray photoelectron spectroscopy, scanning electron microscopy and transmission electron microscopy. The Ni-P cathode performed low onset over-potential, good catalytic activity and long-term stability under neutral and alkaline conditions. The mechanism of Ni-P electrode for hydrogen production was discussed by electrochemical impedance spectroscopy. The excellent performance of Ni-P cathode was mainly attributed to the synergistic effect of phosphate anions and the self-supported feature.     

Microstructure and properties of in-situ synthesized Cu-1 wt%TiC alloy followed by ECAP and post-annealing

A dispersion-strengthened copper alloy with 1 wt% TiC for commercial electrical-contact wires was prepared by in-situ reaction casting, grain-ultrafining by equal-channel angular pressing (ECAP) and subsequent annealing with aim to obtain excellent comprehensive performance. The results showed that fine TiC particles were in-situ synthesized in the as-cast Cu matrix and aggregated in clusters, and thus mechanical properties of the as-cast alloy deemed insufficient. Continued ECAP at 473 K significantly refined the grains of the as-cast alloy and improved the distribution of TiC particles. Due to multiple strengthening mechanisms, the ECAP-processed alloys maintained good conductivity with obviously enhanced tensile strength and hardness values. After post-ECAP annealing, the elongation and conductivity of the fine-grained copper alloy increased with the adequate tensile strength. The novel combined process endows the alloy appropriate performance to serve current high-frequency electrification railway systems.     

PTC124 targets genetic disorders caused by nonsense mutations

Nonsense mutations promote premature translational termination and cause anywhere from 5-70% of the individual cases of most inherited diseases. Studies on nonsense-mediated cystic fibrosis have indicated that boosting specific protein synthesis from <1% to as little as 5% of normal levels may greatly reduce the severity or eliminate the principal manifestations of disease. To address the need for a drug capable of suppressing premature termination, we identified PTC124-a new chemical entity that selectively induces ribosomal readthrough of premature but not normal termination codons. PTC124 activity, optimized using nonsense-containing reporters, promoted dystrophin production in primary muscle cells from humans and mdx mice expressing dystrophin nonsense alleles, and rescued striated muscle function in mdx mice within 2-8 weeks of drug exposure. PTC124 was well tolerated in animals at plasma exposures substantially in excess of those required for nonsense suppression. The selectivity of PTC124 for premature termination codons, its well characterized activity profile, oral bioavailability and pharmacological properties indicate that this drug may have broad clinical potential for the treatment of a large group of genetic disorders with limited or no therapeutic options.     

河北省御道口牧场气候生产潜力估算

御道口牧场位于河北省围场县北部坝上地区,是河北省畜牧业生产的重要产区.根据牧场多年降水和气温等气象观测资料,同时考虑地形因素和最小面积的限制,对御道口牧场的气候生产潜力进行了估算.得出牧场的气候生产潜力在3.75～5 t·hm-2·a-1之间,牧场内适合发展人工草地的平地和缓坡(＜5°)约占总土地面积的76.5%.     

高校化学实验室通风系统研究

针对高校化学实验室的特点,提出化学实验室通风系统、自动控制系统、BENTAX净化系统设计方案。通过对设计方案的研究,为类似工程实践提供可参考的思路和方法。     

长大公路隧道火灾安全疏散性能化设计与分析

基于性能化防火设计方法, 分析火灾条件下长大公路隧道内人 员疏散行为的特点,给出隧道内人 员疏散的安全判据,并结合某隧道 的结构及车流特征对人员疏散过程 进行了数值模拟研究,分析隧道在 正常通车和局部行车堵塞时,不同 火源位置、横通道间距与横通道宽 度对人员疏散时间及安全状态的影 响。结果表明,与建筑内人员疏散不 同,长大公路隧道内火灾的可用安 全疏散时间(ASET)与需要的安全疏 散时间(RSET)均为沿隧道长度方向 位置的函数。隧道内人员安全疏散 的时间曲线在各横通道疏散口出现 峰值,这主要是受到横通道通行能 力的限制,各疏散口人员集聚等待 所致。当隧道发生局部堵塞时,横 通道口需要的安全疏散时间显著增 加,危险性也急剧增大。隧道内人 员疏散的性能化防火设计应综合考 虑火源位置对人员载荷及疏散口位 置可用安全疏散时间的影响。该研 究为公路隧道火灾安全疏散设施的 优化设计提供依据。     

航天医学工程理论与实践

航天医学工程是伴随着我国 近40年载人航天的发展,孕育催生的 一门新兴学科,具有特色鲜明的学科 理论体系和实践技术方法。概述了航 天医学工程的体系构成、研究内容和 学科特点。     

Essential Independent Condition for Graphs to Be Hamiltonian

Let G be a graph of order n．For graph to be Hamiltonian,beginning with Dirac’s classic result in １９５２,Dirac’s theorem was followed by that of Ore in１９６０．In１９８４,Fan generalized Dirac’s theorem and Ore’s theorem as if G is a２-connected graph of order n and max｛d（u）,d（v）｝≥n/２for each pair of vertices u and v with d（u,v）＝２,then G is hamiltonian．In１９９１,Faudree et al proved that if G is a２-connected graph and,| N（u）∪N（v）|＋δ（G）≥n for each pair of nonadjacent vertices u,v∈V（G）,then G is hamiltonian．This paper generalizes the above onditions of Dirac,Ore,Fan and Faudree et al in the case of３-connected graph and proves that if G is a３-connected graph of order n and max｛｜N（x）∪ N（y）｜＋d（u）,｜N（w）∪N（z）｜＋d（v）｝≥n for every choice of６Essential independent vertices,then G is hamiltonian．