全文获取类型
收费全文 | 212篇 |
免费 | 0篇 |
国内免费 | 1篇 |
专业分类
系统科学 | 3篇 |
教育与普及 | 2篇 |
理论与方法论 | 1篇 |
现状及发展 | 49篇 |
研究方法 | 35篇 |
综合类 | 118篇 |
自然研究 | 5篇 |
出版年
2022年 | 1篇 |
2020年 | 1篇 |
2019年 | 2篇 |
2018年 | 2篇 |
2017年 | 1篇 |
2016年 | 1篇 |
2015年 | 2篇 |
2014年 | 1篇 |
2013年 | 4篇 |
2012年 | 16篇 |
2011年 | 24篇 |
2010年 | 10篇 |
2009年 | 4篇 |
2008年 | 7篇 |
2007年 | 17篇 |
2006年 | 14篇 |
2005年 | 14篇 |
2004年 | 10篇 |
2003年 | 10篇 |
2002年 | 14篇 |
2001年 | 1篇 |
2000年 | 7篇 |
1994年 | 1篇 |
1992年 | 2篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1988年 | 4篇 |
1987年 | 1篇 |
1984年 | 2篇 |
1981年 | 1篇 |
1979年 | 3篇 |
1978年 | 2篇 |
1977年 | 5篇 |
1976年 | 3篇 |
1975年 | 2篇 |
1974年 | 2篇 |
1973年 | 4篇 |
1971年 | 4篇 |
1970年 | 2篇 |
1967年 | 1篇 |
1966年 | 3篇 |
1965年 | 1篇 |
1964年 | 1篇 |
1957年 | 2篇 |
1955年 | 1篇 |
1954年 | 1篇 |
排序方式: 共有213条查询结果,搜索用时 15 毫秒
201.
In genetic control of disease, does 'race' matter? 总被引:3,自引:0,他引:3
202.
203.
204.
205.
206.
P. Stern S. Huković M. Radivojević 《Cellular and molecular life sciences : CMLS》1976,32(10):1326-1327
Summary Synthetic Substance P and naloxone abolish the proconvulsive action of morphine on pentetrasol-induced seizures. It is suggested that Substance P could be a natural antagonist of morphine in the central nervous system.
Am 20. März 1976 gestorben. 相似文献
Am 20. März 1976 gestorben. 相似文献
207.
208.
209.
Taguchi A Blood DC del Toro G Canet A Lee DC Qu W Tanji N Lu Y Lalla E Fu C Hofmann MA Kislinger T Ingram M Lu A Tanaka H Hori O Ogawa S Stern DM Schmidt AM 《Nature》2000,405(6784):354-360
The receptor for advanced glycation end products (RAGE), a multi-ligand member of the immunoglobulin superfamily of cell surface molecules, interacts with distinct molecules implicated in homeostasis, development and inflammation, and certain diseases such as diabetes and Alzheimer's disease. Engagement of RAGE by a ligand triggers activation of key cell signalling pathways, such as p21ras, MAP kinases, NF-kappaB and cdc42/rac, thereby reprogramming cellular properties. RAGE is a central cell surface receptor for amphoterin, a polypeptide linked to outgrowth of cultured cortical neurons derived from developing brain. Indeed, the co-localization of RAGE and amphoterin at the leading edge of advancing neurites indicated their potential contribution to cellular migration, and in pathologies such as tumour invasion. Here we demonstrate that blockade of RAGE-amphoterin decreased growth and metastases of both implanted tumours and tumours developing spontaneously in susceptible mice. Inhibition of the RAGE-amphoterin interaction suppressed activation of p44/p42, p38 and SAP/JNK MAP kinases; molecular effector mechanisms importantly linked to tumour proliferation, invasion and expression of matrix metalloproteinases. 相似文献
210.
Initiation of neural induction by FGF signalling before gastrulation 总被引:17,自引:0,他引:17
During neural induction, the 'organizer' of the vertebrate embryo instructs neighbouring ectodermal cells to become nervous system rather than epidermis. This process is generally thought to occur around the mid-gastrula stage of embryogenesis. Here we report the isolation of ERNI, an early response gene to signals from the organizer (Hensen's node). Using ERNI as a marker, we present evidence that neural induction begins before gastrulation--much earlier in development than previously thought. We show that the organizer and some of its precursor cells produce a fibroblast growth factor signal, which can initiate, and is required for, neural induction. 相似文献