Memory

Memories become stabilized through a time-dependent process that requires gene expression and is commonly known as consolidation. During this time, memories are labile and can be disrupted by a number of interfering events, including electroconvulsive shock, trauma and other learning or the transient effect of drugs such as protein synthesis inhibitors. Once consolidated, memories are insensitive to these disruptions. However, they can again become fragile if recalled or reactivated. Reactivation creates another time-dependent process, known as reconsolidation, during which the memory is restabilized. Here we discuss some of the questions currently debated in the field of memory consolidation and reconsolidation, the molecular and anatomical requirements for both processes and, finally, their functional relationship.     

Interferon-alpha and transforming growth factor-β co-induce growth inhibition of human tumor cells

A hallmark of resistance to type I interferons (IFNs) is the lack of antiproliferative responses. We show here that costimulation with IFN-alpha and transforming growth factor beta-1 (TGF-beta) potentiates antiproliferative activity in a sensitive (ME15) and resistant (D10) human melanoma cell line. A DNA microarray-based search for proliferation control genes involved that are cooperatively activated by IFN-alpha and TGF-beta, yielded 28 genes. Among these are the insulin-like growth factor-binding protein 3 (IGFBP3) and the calcium-binding protein S100A2; we demonstrate, that recombinant IGFBP3 protein is a potent growth inhibitor requiring TGF-beta activity. The antiproliferative activity of S100A2 is significantly enhanced by IFN-alpha in stably transfected ME15 or D10 cell lines. We show for the first time that IFN-alpha is a potent inducer of intracellular calcium release required for activation of S100A2. Our study provides a functional link between IFN-alpha and TGF-beta signaling and extends the function of IFN signaling to calcium-sensitive processes.     

高性能高应变InGaAs量子阱脊型波导半导体激光器

介绍了利用分子束外延系统生长高应变InGaAs量子阱半导体激光器材料, 采用脉冲阳极氧化技术制作脊型波导半导体激光器. 4 μm条宽脊型波导半导体激光器在室温下单面连续输出功率达到50 mW. 腔长600 μm时, 器件阈值电流密度为300 A/cm2. 在100 mA电流下, 激光器的峰值波长为1.19 μm, 激光器的最大斜率效率为0.45 W/A. 在20℃至100℃温度下, 激光器的特征温度为129 K.     

Genetic algorithm for pareto optimum-based route selection

A quality of service (QoS) or constraint-based routing selection needs to find a path subject to multiple constraints through a network. The problem of finding such a path is known as the multi-constrained path(MCP) problem, and has been proven to be NP-complete that cannot be exactly solved in a polynomial time. The NPC problem is converted into a multiobjective optimization problem with constraints to be solved with a genetic algorithm. Based on the Pareto optimum, a constrained routing computation method is proposed to generate a set of nondominated optimal routes with the genetic algorithm mechanism. The convergence and time complexity of the novel algorithm is analyzed. Experimental results show that multiobjective evolution is highly responsive and competent for the Pareto optimum-based route selection. When this method is applied to a MPLS and metropolitan-area network, it will be capable of optimizing the transmission performance.     

基于麻雀搜索算法优化支持向量机的刀具磨损识别

针对微小深孔钻削刀具磨损状态检测的工程需求,提出了基于钻削声信号的麻花钻头磨损状态识别方法.根据不同磨损程度的麻花钻在钻削过程中的声信号,使用经验模态分解(empirical mode decomposition,EMD)将声信号分解成若干个固有模态函数(intrinsic mode functions,IMFs),通...     

哈尔滨市平房区中水回用可行性研究

通过相关类比分析,确定污水处理采用BAF滤池工艺+絮凝沉淀+消毒即可满足中水回用标准,且具有较好经济效益.     

在化学实验教学中渗透人文精神

以实验为基础是化学教学的最基本特征;实践教学环节对于培养学生的实践能力和创新能力尤其重要。从培养和谐发展人才的教育目标出发,研究了古今中外化学实验教学中的成功经验、存在问题及改革动态,分析了在化学实验教学中融合人文教育的优越性,探索出了化学实验教学中渗透人文教育的途径：规范课前预习要求,规范操作过程管理,循序渐进设计实验层次,积极有效与学生沟通,引导学生领悟化学文化。