塑性变形和热处理工艺对白口铸铁组织及性能的改善

大于2.11％C的白口铸铁中含有大块且又分布不均匀的渗碳体,其塑性和韧性很差。本文采用塑性变形及热处理等4种方法,最终得到了细小碳化物均匀分布在铁素体基体上的理想组织。具有这种球化组织的铸铁,强韧性有了提高,且在650～850℃温度范围变形表现出良好的超塑特性。     

用粘度法研究石油中沥青质沉积的起始点

介绍了测定混合物粘度以确定沥青质沉积起始点的方法，考察了将正庚烷或甲苯加入油样过程中体系粘度的变化规律．结果发现，随着正庚烷的加入，体系的粘度呈下降趋势，但在某一浓度时出现明显的偏离，该点即被定义为沥青质沉积的起始点．而用甲苯作溶剂时，体系粘度则始终呈平缓下降趋势，无偏离现象研究还发现，各种原油的沥青质沉积的起始点明显早于其相应的减压渣油，这表明渣油胶体体系比原油的更为稳定，上述结果借助显微照相观察得以证实     

The parameter determination in the design of 3-D spherically symmetric FIR filters via the McClellan transformation

In the design of 3-D spherically symmetric FIR filters via the McClellan transformation, two methods are proposed to determine the transformation parameters. The first is to improve the original 3-D algorithm by exploiting the 2-D effective methods in 3-D. This method can change the constrained optimization algorithm into the unconstrained one and makes the design easier to realize. The second method is to solve the coupled equations under constrained conditions and a set of ideal parameters can be gotten. The design example shows that the two methods are all efficient and easier than the original algorithm. Supported by the National Natural Science Foundation of China Jin Xiaoying: born in 1975, Graduate student     

拟南芥逆境胁迫诱导转录因子DREB1A基因的克隆和序列分析

以拟南芥基因组DNA为模板,通过PCR扩增得到逆境胁迫诱导转录因子DREB1A基因,将其克隆到pUC19质粒中.序列分析表明获得的基因序列与已报道的该基因的序列完全相同.     

Zebrafish miR-214 modulates Hedgehog signaling to specify muscle cell fate

Numerous microRNAs (miRNAs) have been discovered in the genomes of higher eukaryotes, and functional studies indicate that they are important during development. However, little is known concerning the function of individual miRNAs. We approached this problem in zebrafish by combining identification of miRNA expression, functional analyses and experimental validation of potential targets. We show that miR-214 is expressed during early segmentation stages in somites and that varying its expression alters the expression of genes regulated by Hedgehog signaling. Inhibition of miR-214 results in a reduction or loss of slow-muscle cell types. We show that su(fu) mRNA, encoding a negative regulator of Hedgehog signaling, is targeted by miR-214. Through regulation of su(fu), miR-214 enables precise specification of muscle cell types by sharpening cellular responses to Hedgehog.     

Germline gain-of-function mutations in SOS1 cause Noonan syndrome

Noonan syndrome, the most common single-gene cause of congenital heart disease, is characterized by short stature, characteristic facies, learning problems and leukemia predisposition. Gain-of-function mutations in PTPN11, encoding the tyrosine phosphatase SHP2, cause approximately 50% of Noonan syndrome cases. SHP2 is required for RAS-ERK MAP kinase (MAPK) cascade activation, and Noonan syndrome mutants enhance ERK activation ex vivo and in mice. KRAS mutations account for <5% of cases of Noonan syndrome, but the gene(s) responsible for the remainder are unknown. We identified missense mutations in SOS1, which encodes an essential RAS guanine nucleotide-exchange factor (RAS-GEF), in approximately 20% of cases of Noonan syndrome without PTPN11 mutation. The prevalence of specific cardiac defects differs in SOS1 mutation-associated Noonan syndrome. Noonan syndrome-associated SOS1 mutations are hypermorphs encoding products that enhance RAS and ERK activation. Our results identify SOS1 mutants as a major cause of Noonan syndrome, representing the first example of activating GEF mutations associated with human disease and providing new insights into RAS-GEF regulation.     

基于构件建造信息系统的自适应体系结构

本文基于Ｈ．Ａ．Ｓｉｍｏｎ的决策认知过程分析,提出了一种用构件组装方式产生适应不同需求的信息系统。为了提高研制效率,给出了信息系统及其构件的形式化描述。在软件集成块 Ｓｏｆｔｗａｒｅ－ＩＣ的思路影响下提出了一种系统构成的自组织方法。     

应用生物信息学鉴定急性STEMI患者通路及Hub基因

利用基因表达综合数据库数据集的生物信息学分析,确定4h内STEMI患者血液RNA诊断生物标志物。从基因表达综合数据库中提取RNA表达谱数据集,寻找差异表达基因并对差异基因进行富集分析,在蛋白相互作用网络中筛选Hub基因,建立了基于Hub基因的随机森林模型和逻辑回归模型。结果表明,与健康对照组比较,STEMI患者中鉴定出300个明显DEGs。炎症和免疫相关的途径显著富集,鉴定出7个关键基因,即FPR2、ITGAM、BST1、CEACAM8、MMP9、ELANE和FPR1。通过对7个Hub基因构建随机森林模型和逻辑回归模型,准确地将STEMI样本与健康对照样本分开,对STEMI的预测具有较高的准确性。     

Strong Law of Large Numbers for Weighted Sums of Random Variables and Its Applications in EV Regression Models

This paper mainly studies the strong convergence properties for weighted sums of extended negatively dependent(END, for short) random variables. Some sufficient conditions to prove the strong law of large numbers for weighted sums of END random variables are provided. In particular, the authors obtain the weighted version of Kolmogorov type strong law of large numbers for END random variables as a product. The results that the authors obtained generalize the corresponding ones for independent ra...     

Fuzzy Filter Design for Affine Systems with Sensor Faults: A Dynamic Event-Triggered Approach

This study addresses the issue of dynamic event-triggered-based filtering for fuzzy affine systems. To alleviate the utilization of constraint bandwidth resources and improve the efficiency of the signals exchange, a dynamic event-triggered protocol is forwarded to regulate the trigger instants with objective system states. Meanwhile, the nonhomogeneous Markov process is proposed to characterize the dynamic behaviors of sensor faults, where the time-varying transition probabilities belong to a c...