一种基于不同粒度语言判断矩阵的群决策方法

针对基于不同粒度语言判断矩阵的群决策问题,提出了一种新的群决策分析方法.对有序语言短语集中的语言短语进行“量化”,通过变量转换关系将语言判断矩阵转换为互补判断矩阵,并进行了判断信息转换的一致性分析;采用OWA算子将每个决策者给出语言判断矩阵所对应的互补判断矩阵集结为群的偏好矩阵,并通过计算每个方案的优势度来确定最优方案;最后给出一个算例说明了所提出的方法的有效性与实用性.     

多精英采样与个体差分学习的分布估计算法

提出了基于多精英采样和差分搜索的分布估计算法EDA-M/D (Estimation distribution algorithm based on multiple elites sampling and individuals differential search)。EDA-M/D利用多精英个体独立采样生成子代来提升算法全局搜索能力,利用精英群体分布的σ²约束采样半径,实现种群从全局搜索逐步过度到局部搜索。当精英群体停滞时,劣势个体借助精英群体的μ和种群历史最优解进行差分搜索,帮助种群跳出局部最优解。通过多精英采样与差分搜索的自适应协同实现种群宏观信息与个体微观信息的有机融合。实验结果表明EDA-M/D在稳定性和搜索能力方面均表现出明显的优势。     

市场机制和政府调控下的产学研合作创新网络演化博弈仿真——以新能源汽车产业为例

以新能源汽车产学研合作创新网络为实证分析对象,运用网络演化博弈理论和仿真分析方法,剖析在市场机制和政府调控下,产学研合作创新网络中创新主体合作行为与网络结构在互动过程下的演化规律。研究结果表明：市场机制和政府调控对于创新主体维护合作行为和网络集聚都具有促进作用;创新主体合作行为与网络结构之间具有协同互动关系,并且市场机制和政府调控的作用越大,两者间协同互动作用越明显。在市场机制下,市场机制作用的增强会降低网络演化的速度;只有当市场机制作用超过一定阈值时,维护合作行为才会在创新主体间涌现出来。在政府调控下,创新主体对于政府调控较为敏感;当政府调控力度处于阈值水平时,不利于创新主体间合作关系的维持。     

自动固相萃取法(SPE)提取血(尿)中的吗啡及其色谱检测

目的:建立了一种在同一条件下同时净化提取血(尿)中吗啡(Morphine)的自动固相萃取法(Solid-Phase Extraction,SPE);方法:利用Waters公司的Isolutetmspe柱(离子交换柱:Confirm HCX)进行分离提取,采用气相色谱-质谱法(GC/MS)和高效液相色谱法(HPLC)进行检测;结果:利用GC/MS和HPLC法检测,其样品中Morphine的回收率均可达95%以上;结论:该法具有简便快捷、提取回收率高、杂质含量少、背景噪音低等优点。     

A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia

Non-obstructive azoospermia (NOA) is one of the most severe forms of male infertility. Its pathophysiology is largely unknown, and few genetic influences have been defined. To identify common variants contributing to NOA in Han Chinese men, we performed a three-stage genome-wide association study of 2,927 individuals with NOA and 5,734 controls. The combined analyses identified significant (P < 5.0 × 10(-8)) associations between NOA risk and common variants near PRMT6 (rs12097821 at 1p13.3: odds ratio (OR) = 1.25, P = 5.7 × 10(-10)), PEX10 (rs2477686 at 1p36.32: OR = 1.39, P = 5.7 × 10(-12)) and SOX5 (rs10842262 at 12p12.1: OR = 1.23, P = 2.3 × 10(-9)). These findings implicate genetic variants at 1p13.3, 1p36.32 and 12p12.1 in the etiology of NOA in Han Chinese men.     

Mutations in NMNAT1 cause Leber congenital amaurosis and identify a new disease pathway for retinal degeneration

Leber congenital amaurosis (LCA) is a blinding retinal disease that presents within the first year after birth. Using exome sequencing, we identified mutations in the nicotinamide adenine dinucleotide (NAD) synthase gene NMNAT1 encoding nicotinamide mononucleotide adenylyltransferase 1 in eight families with LCA, including the family in which LCA was originally linked to the LCA9 locus. Notably, all individuals with NMNAT1 mutations also have macular colobomas, which are severe degenerative entities of the central retina (fovea) devoid of tissue and photoreceptors. Functional assays of the proteins encoded by the mutant alleles identified in our study showed that the mutations reduce the enzymatic activity of NMNAT1 in NAD biosynthesis and affect protein folding. Of note, recent characterization of the slow Wallerian degeneration (Wld(s)) mouse model, in which prolonged axonal survival after injury is observed, identified NMNAT1 as a neuroprotective protein when ectopically expressed. Our findings identify a new disease mechanism underlying LCA and provide the first link between endogenous NMNAT1 dysfunction and a human nervous system disorder.     

国家治理现代化与企业战略重构

公共治理作为外部治理机制影响企业的战略决策行为。我国当前最突出的公共治理改革就是建设现代化的国家治理体系。基于产权性质与政治关联的视角检验了国家治理变迁后的企业战略重构行为。在整体上发现了国家治理现代化建设以来我国上市公司战略重构的证据;有政治关联的企业更能顺应环境变化及时进行战略调整;国有产权推动了国家治理现代化建设以来企业的战略重构,但是其作用区域主要体现在缩减关系型战略支出方面,国有企业战略重构的主动性不足。本文的研究可用以评价国家治理现代化建设的效率与效果,为未来改革与发展的路径安排提供经验依据,为企业未来可持续发展提供对策建议。     

Generating semi-algebraic invariants for non-autonomous polynomial hybrid systems

Hybrid systems are dynamical systems with interacting discrete computation and continuous physical processes, which have become more common, more indispensable, and more complicated in our modern life. Particularly, many of them are safety-critical, and therefore are required to meet a critical safety standard. Invariant generation plays a central role in the verification and synthesis of hybrid systems. In the previous work, the fourth author and his coauthors gave a necessary and sufficient condition for a semi-algebraic set being an invariant of a polynomial autonomous dynamical system, which gave a confirmative answer to the open problem. In addition, based on which a complete algorithm for generating all semi-algebraic invariants of a given polynomial autonomous hybrid system with the given shape was proposed. This paper considers how to extend their work to non-autonomous dynamical and hybrid systems. Non-autonomous dynamical and hybrid systems are with inputs, which are very common in practice; in contrast, autonomous ones are without inputs. Furthermore, the authors present a sound and complete algorithm to verify semi-algebraic invariants for non-autonomous polynomial hybrid systems. Based on which, the authors propose a sound and complete algorithm to generate all invariants with a pre-defined template.     

基于模拟有限差分的嵌入式离散裂缝数学模型

嵌入式离散裂缝模型划分网格时不需要考虑油藏内的裂缝形态,只需对基岩系统进行简单的网格剖分,可以大大降低网格划分的复杂度,从而能够提高计算效率.并且该模型可以将现有成熟的油藏数值模拟技术和离散裂缝网络模型有机地结合起来,能精细地模拟流体在裂缝性油藏中的流动.本文模型求解采用模拟有限差分方法,该方法基于单个网格的节点和面信息构造数值计算格式,理论上适用于任何复杂网格系统,且具有良好的局部守恒性,将其推广到嵌入式离散裂缝模型后,克服了该模型基于有限差分方法求解时不能有效处理全张量形式的渗透率以及不适用于复杂边界形状裂缝性油藏的局限性.最后通过实际算例验证了本文方法的正确性和优越性.     

东濮凹陷胡庆地区原油地球化学特征与油源分析

研究东濮凹陷胡庆地区原油地球化学特征及其来源.利用有机地球化学分析方法,对原油与烃源岩进行饱和烃色谱、饱和烃与芳烃色谱-质谱分析,剖析了两者的分子地球化学特征及油源.研究表明:胡庆地区发育3类原油,第一类原油具有极高伽马蜡烷,质量色谱图中甾烷呈"L"形特征,来自第二台阶的沙一段烃源岩,在沙一段储层中富集形成自生自储常温...