基于多级分类器的自由手写数字在线识别

设计了一种用于手写字符在线识别的多级分类器模型。在该模型中,通过对四个独立的分类算法进行集成,将脱机方法与联机方法,神经网络方法与传统方法有机地结合起来构成一个完整的手写字符在线识别系统。理论分析和实验结果表明,该集成系统比单一系统具有明显的优越性。     

开放科学及建构的制度逻辑

科学与技术是两种不同的制度模式,前者属于科学共和国"Republic of Science",后者属于技术王国"Realm of Technology",两者具有天生的互补性。开放科学作为一种非市场化的激励制度,提出一套基于优先权的报酬体制,强调在知识产权保护前提下追求创新知识社会福利的最大化,对于催生高质量的研究和创新(Research&Innovation)至关重要。本文在阐述开放科学起源、发展与理论内涵的基础上,重点从公共资助、累积创新、知识产权保护和知识分工四个方面,深入探究了开放科学建构的制度逻辑。     

土壤水力侵蚀能量力学机理的理论分析

根据力学和物质与能量原理，对土壤水力侵蚀这一自然地理现象从哲学的高度进行分析，认为水动力作用是土壤水力侵蚀的根本原因；物质与能量守恒是土壤水力侵蚀的基本法则；侵蚀与沉积并存是土壤水力侵蚀的普遍规律。提出基于能量力学机理的3个土壤水力侵蚀的新理论，即侵蚀平衡理论、最大梯度理论和水流侵蚀力理论。指出按这种思想建立的数学模型能揭示土壤水力侵蚀的规律，因而具有重要的理论和应用价值。     

New crystal structure of molecular complex 1-piperidine carboxylate-piperidinium-H<Subscript>2</Subscript>O studied by X-ray single crystal diffraction

Piperidine absorbs CO2 and H2O in air to form a molecular complex： piperidium-l-piperidinecarboxylate-H2O. The structure of the complex was characterized by X-ray single crystal diffraction. The crystal structure was determined to be triclinic, space group P1^-with a=0.648 6（8） nm, b=0.809 200） nm, c= 1.357 1（16） nm, a=96.96706）°, β =102.506（15）°,γ=104.202 05）°, Z=2. The complex is stabilized via five hydrogen bonds between the three components, N-O electrostatic interaction and O-O interaction （electron transfer） betweenl-piperidinecarboxylate and H2O. Due to electron transference of carbamate ion, the oxygen atom in water molecule is strongly negatively charged and the O-H bond is considerably shorter than that of the free molecule of water. The formation of the molecular complex is a reversible process and will decompose upon heating. The mechanism of formation and stabilization is further investigated herein.     

O2流量对O2/C4F8等离子体刻蚀SiCOH低k薄膜的影响

研究了O2/C4F8等离子体刻蚀SiCOH低k薄膜时O2流量对刻蚀率、表面结构的影响,及其放电等离子体特性的关联.发现O2流量的增大可以极大地提高多孔SiCOH薄膜的刻蚀速率,降低表面的粗糙度,减少SiCOH薄膜表面的C:F沉积.等离子体特性的光谱分析表明,O2的添加,增强了C与O之间的反应,从而在Si、F反应刻蚀Si的同时,C、O之间的反应使C消耗,实现Si、C的同步刻蚀,从而获得SiCOH低k薄膜的高刻蚀率和低粗糙度表面.     

The industrial asymmetry of the stock price prediction with investor sentiment: Based on the comparison of predictive effects with SVR

As a representative emerging financial market, the Chinese stock market is more prone to volatility because of investor sentiment. It is reasonable to use efficient predictive methods to analyze the influence of investor sentiment on stock price forecasting. This paper conducts a comparative study about the predictive performance of artificial neural network, support vector regression (SVR) and autoregressive integrated moving average and selects SVR to study the asymmetry effect of investor sentiment on different industry index predictions. After studying the relevant financial indicators, the results divide the Shenwan first-class industries into two types and show that the industries affected by investor sentiment are composed of young companies with high growth and high operative pressure and there are a great number of investment bubbles in those companies.     

基于烟花算法的基站群协作计算卸载模型研究

车联网、AR、AI等计算密集、时延敏感型应用迅速发展,而移动设备因自身计算能力相对不足,执行此类应用任务时会因高时延而严重影响用户体验甚至无法满足用户需求。针对此问题,提出综合考虑时延与成本的多用户、多MEC (mobile edge computing)服务器的基站群协作计算卸载模型。并提出基于凸优化的改进烟花算法（improved fireworks algorithm based on convex optimization, CVX-FWA）来对模型进行求解,对用户任务进行合理的卸载与资源分配。仿真结果表明,提出的计算卸载方案有效降低了任务总时延成本值,实现计算卸载资源的整体优化配置。     

信号交叉口人机混驾交通流速度控制策略建模

为分析人机混驾交通流下网联自动驾驶车辆（connected and autonomous vehicles,CAV）速度控制策略对交通流运行特征的影响,构建了考虑驾驶员对行车信息获取不确定性的人工驾驶车辆交叉口通行决策模型。提出考虑前车速度影响的自动驾驶速度控制策略,构建信号交叉口连续型元胞自动机更新规则,通过引入不同CAV渗透率、道路饱和度、控制区长度参数,研究CAV速度控制策略对信号交叉口交通流运行特征的影响。结果表明：CAV能显著提高交叉口通行能力,且车流通过交叉口区域的延误显著降低;同时速度控制策略的实施效果还受控制区长度的影响,呈现出随着控制区长度的增加,车均延误逐渐降低并趋于稳定。     

Differentiated cells are more efficient than adult stem cells for cloning by somatic cell nuclear transfer

Since the creation of Dolly via somatic cell nuclear transfer (SCNT), more than a dozen species of mammals have been cloned using this technology. One hypothesis for the limited success of cloning via SCNT (1%-5%) is that the clones are likely to be derived from adult stem cells. Support for this hypothesis comes from the findings that the reproductive cloning efficiency for embryonic stem cells is five to ten times higher than that for somatic cells as donors and that cloned pups cannot be produced directly from cloned embryos derived from differentiated B and T cells or neuronal cells. The question remains as to whether SCNT-derived animal clones can be derived from truly differentiated somatic cells. We tested this hypothesis with mouse hematopoietic cells at different differentiation stages: hematopoietic stem cells, progenitor cells and granulocytes. We found that cloning efficiency increases over the differentiation hierarchy, and terminally differentiated postmitotic granulocytes yield cloned pups with the greatest cloning efficiency.     

Cilioplasm is a cellular compartment for calcium signaling in response to mechanical and chemical stimuli

Primary cilia with a diameter of ~200 nm have been implicated in development and disease. Calcium signaling within a primary cilium has never been directly visualized and has therefore remained a speculation. Fluid-shear stress and dopamine receptor type-5 (DR5) agonist are among the few stimuli that require cilia for intracellular calcium signal transduction. However, it is not known if these stimuli initiate calcium signaling within the cilium or if the calcium signal originates in the cytoplasm. Using an integrated single-cell imaging technique, we demonstrate for the first time that calcium signaling triggered by fluid-shear stress initiates in the primary cilium and can be distinguished from the subsequent cytosolic calcium response through the ryanodine receptor. Importantly, this flow-induced calcium signaling depends on the ciliary polycystin-2 calcium channel. While DR5-specific agonist induces calcium signaling mainly in the cilioplasm via ciliary CaV1.2, thrombin specifically induces cytosolic calcium signaling through the IP₃ receptor. Furthermore, a non-specific calcium ionophore triggers both ciliary and cytosolic calcium responses. We suggest that cilia not only act as sensory organelles but also function as calcium signaling compartments. Cilium-dependent signaling can spread to the cytoplasm or be contained within the cilioplasm. Our study thus provides the first model to understand signaling within the cilioplasm of a living cell.