美国的文艺复兴——超验主义与美国民族文学的形成和发展

美国文学的历史相对短暂,但是它自诞生以来,迅速地得以发展、丰富、成熟,现已成为举世瞩目的文学。在美国文学的历史上,浪漫主义及超验主义对美国文学的形成、繁荣和发展起过巨大的作用,正如文艺复兴对西方文学的影响一样,意义深远,至关重要。     

SO_4~(2-)/ZrO_2介孔氧化物的合成及表征

以十二烷基硫酸钠(SDS)为模板剂,乙二胺为碱介质,水热法合成ZrO2介孔材料。焙烧之后,在不同浓度的硫酸溶液中浸渍反应,得到SO42-/ZrO2介孔氧化物。研究结果表明,当n(Zr)︰n(SDS)︰n(H2NCH2CH2NH2)︰n(H2O)=1.0︰1.0︰1.6︰200,反应温度为60℃时,所合成的介孔氧化物在0.5 mol.L-1 H2SO4溶液中浸渍3.5 h,550℃焙烧2 h,产物的酸量为1.905 4 mmol.g-1。     

基于MatlabBP算法预测WCDMA手机待机电流及异常数据分析

3G手机待机耗电问题已成为研究的重点.本文主要分析影响WCDMA手机待机电流的重要因素,提出一种对WCDMA手机待机耗电预测新方法.此方法是基于Matlab软件,并采用人工神经网络BP算法.并在此基础上对异常电流数据进行简单分析.     

The prolyl isomerase Pin1 is a regulator of p53 in genotoxic response

p53 is activated in response to various genotoxic stresses resulting in cell cycle arrest or apoptosis. It is well documented that DNA damage leads to phosphorylation and activation of p53 (refs 1-3), yet how p53 is activated is still not fully understood. Here we report that DNA damage specifically induces p53 phosphorylation on Ser/Thr-Pro motifs, which facilitates its interaction with Pin1, a member of peptidyl-prolyl isomerase. Furthermore, the interaction of Pin1 with p53 is dependent on the phosphorylation that is induced by DNA damage. Consequently, Pin1 stimulates the DNA-binding activity and transactivation function of p53. The Pin1-mediated p53 activation requires the WW domain, a phosphorylated Ser/Thr-Pro motif interaction module, and the isomerase activity of Pin1. Moreover, Pin1-deficient cells are defective in p53 activation and timely accumulation of p53 protein, and exhibit an impaired checkpoint control in response to DNA damage. Together, these data suggest a mechanism for p53 regulation in cellular response to genotoxic stress.