Finding finer functions for partially characterized proteins by protein-protein interaction networks

Based on high-throughput data, numerous algorithms have been designed to find functions of novel proteins. However, the effectiveness of such algorithms is currently limited by some fundamental factors, including (1) the low a-priori probability of novel proteins participating in a detailed function; (2) the huge false data present in high-throughput datasets; (3) the incomplete data coverage of functional classes; (4) the abundant but heterogeneous negative samples for training the algorithms; and (5) the lack of detailed functional knowledge for training algorithms. Here, for partially characterized proteins, we suggest an approach to finding their finer functions based on protein interaction sub-networks or gene expression patterns, defined in function-specific subspaces. The proposed approach can lessen the above-mentioned problems by properly defining the prediction range and functionally filtering the noisy data, and thus can efficiently find proteins’ novel functions. For thousands of yeast and human proteins partially characterized, it is able to reliably find their finer functions (e.g., the translational functions) with more than 90% precision. The predicted finer functions are highly valuable both for guiding the follow-up wet-lab validation and for providing the necessary data for training algorithms to learn other proteins.     

"服务型教育体系"与广告专业教学模式创新探索

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弧焊机器人控制系统

本文介绍一种二级计算机控制的弧焊机器人控制系统。在考虑相邻关节影响的条件下，对弧焊机器人控制系统的硬件电路和控制方法进行了分析和设计．     

中药材中孳生粉螨的初步调查

本文采用清水漂浮法和塔氏电热集螨器分离法,共分离中药材样本124种,1240份,从中分离出粉螨45种,隶属7科23属.得出结论:中药材粉螨的污染严重,应加强对中药螨类的防治,以保护中药材及预防人体螨病.     

软件补偿方法在测温智能仪表中的应用

软件补偿方法具有效果好、精确度高、成本低的优点。介绍了在研制多点巡回检测仪中采用的几种软件补偿方法：前向通道特性补偿使放大器等元件不因外界条件的变化而受到任何影响；引线电阻的补偿可实现引线电阻对系统无任何影响；热电阻、热电偶的非线性度补偿效果明显，节省开销。     

多目标多阶段决策问题最优化方法及应用

本文提出了可行状态点,可行边和可行策略等概念,建立了一种新的解决多目标多阶段决策问题的方法,介绍了这一方法的应用实例:     

新的基团法估算沸点下蒸发焓

提出了估算沸点下蒸发焓的含基团重量分率的基团法和估算式，拟合团贡献值，对３８５种有机物的计算平均偏差约为１．５％。所提出的新方法明显优于３种对应状态和用蒸发熵的基团法。     

内河浅隧道双尾工作艇的设计

双尾型船是一种优良节能船型，详细介绍我国北方首例内河浅隧道双尾船的设计，指出该船型在浅水中的优越性及设计中应该重视的尾部振动问题及解决这一问题的方法。     

金属在福州地热水中的腐蚀热力学研究──(I)、铜—地热水系统

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