复方沙棘对小鼠骨髓细胞微笑微核率的影响

复方沙棘由沙棘油、沙棘浸膏、酶解珍珠粉、酪蛋白等配制组成,以沙棘成熟果实为主料.沙棘(hippophae rhamnoides L)系胡颓子科沙棘属,属藏蒙医习用药材,富含多种维生素、氨基酸、微量元素,以及黄酮、有机酸、甾醇、生物碱等物质,是一种营养和药用价值都很高的野生植物.临床应用表明:复方沙棘具有比较全面的生理活性,能调节免疫功能,改善冠状动脉血供,降低过氧化脂质,并具有抗氧化和延     

105例肺癌患者外周血中miRNA-10b的表达

目的 探讨miRNA-10b在非小细胞肺癌(Non-small cell lung cancer,NSCLC)患者外周血的表达情况.方法 选取156例非小细胞肺癌患者,其中,105例列入实验组,51例排除入组,另选50例健康志愿人员为正常组.采用实时荧光定量PCR(RT-qPCR)检测两组外周血中miRNA-10b的表...     

一种计算冲压零件轮廓相似度的快速算法

为了适应网络应用对轮廓相似度计算在速度和数据传输量方面的要求,文中提出了一种非离散的快速算法,该算法采用直线和圆弧来表达轮廓曲线．在对图形进行范化处理后,将待匹配轮廓按照一定步距进行旋转．然后依次以待匹配轮廓或目标轮廓作为模板,计算模板的所有顶点与其在另一个轮廓中对应点的距离平方的平均值．在所有角度中,平均值之和的最小值即为两个轮廓的匹配度．该算法同时适用于凸多边形和凹多边形,并具有较好的区分度和匹配准确性．和以往的离散方式相比,该算法减少了需要传递的数据量．提高了运算速度．     

The multifaceted role of periostin in tumorigenesis

Periostin, also called osteoblast-specific factor 2 (OSF-2), is a member of the fasciclin family and a disulfide-linked cell adhesion protein that has been shown to be expressed preferentially in the periosteum and periodontal ligaments, where it acts as a critical regulator of bone and tooth formation and maintenance. Furthermore, periostin plays an important role in cardiac development. Recent clinical evidence has also revealed that periostin is involved in the development of various tumors, such as breast, lung, colon, pancreatic, and ovarian cancers. Periostin interacts with multiple cell-surface receptors, most notably integrins, and signals mainly via the PI3-K/Akt and other pathways to promote cancer cell survival, epithelial–mesenchymal transition (EMT), invasion, and metastasis. In this review, aspects related to the function of periostin in tumorigenesis are summarized.     

浙江省第12届大学生运动会定向比赛述评

通过对浙江省第12届大学生运动会定向比赛的组织、场地、地图等的综述和比赛成绩的分析,发现本次比赛各项工作合理和顺利,比赛成绩也充分体现了各校的实际水平.同时针对浙江省高校开展学生定向运动比赛中存在的主要问题提出了解决的办法,为改进浙江省定向比赛的组织工作,提高该省定向运动训练、竞技水平提出相应的建议.     

一种基于555集成电路的恒温器设计

文章通过对555电路的分析,结合双向可控硅和运放F007的特性进行恒温电路设计.     

一种基于555集成电路的恒温器设计

文章通过对555电路的分析，结合双向可控硅和运放F007的特性进行恒温电路设计。     

高炉上料系统的变频调速改造

文章阐述了高炉上料系统的变频调速改造,提出了改造的必要性及改造方案,说明了运行效果的表现性.     

A bioinformatic evaluation of potential allergenicity of 85 candidate genes in transgenic organisms

The potential of genetically modified organisms(GMOs) to increase allergenicity or predispositions to allergies has attracted much attention.An approach that will properly and holistically evaluate the allergenicity of GMOs is yet to be found.Here,85 transgenes that have been reported in both international and domestic studies during recent years are summarized case by case;49 of the transformed genes were from plant sources and 36 were from animal sources.EVALLERTM,a web server for the in silico assessment of potential protein allergenicity,was used to evaluate the potential of the transgenic proteins as allergens.The biomedical journals listed in Highwire(http://highwire.stanford.edu/) were searched and reviewed to decipher whether any of the transformed genes were linked to allergenicity or human health.The EVALLER analysis identified 5 allergenic genes,whilst our literature review found 11 genes that were either related to allergic cases or to clinical adverse events;all 16 of these genes have been used in GMOs.The analysis pathway that we have developed can help guide the selection of genes to be used in genetic modification.The pathway also provides a paradigm for allergenicity analysis of transgene candidates.