Template/surfactant free and UV light irradiation assisted fabrication of Mn-Co oxides composite nanorings: Structure and synthesis mechanism

A facile, green, cost effective, and template or surfactant free strategy via a two-step route i.e. UV irradiation followed by dissolution-growth for the controlled synthesis of Mn-Co composite nanorings at room temperature was proposed. The nanorings structures and the process were systematically studied via TEM, HRTEM, EDX and XRD. Bir-MnO_2 nanosheets first formed through the direct photolysis of KMnO_4 under UV light irradiation. This was followed by a dissolution-growth process via the dissolution of Bir-MnO_2 nanosheets by the generated H~+ from the redox reaction between the added Co(NO_3)_2 and residual KMnO_4, as well as the accompanied formation of CoOOH, and Mn-Co composite nanorings. It was found that a balance between the dissolution and growth rate was needed. Suitable pH, KMnO_4 presence and the starting nanosheets like Bir-MnO_2 were the key factors for the formation of nanorings. The obtained Mn-Co nanorings/TiO_2 showed enhanced efficiency for the catalytic oxidation of HCHO. Based on the above understandings, it is believed that the developed dissolution-growth method can be adopted for the designing and preparation of other Mn-Co composite nanostructures which can be further applied for environmental pollution remediation.     

实时三维超声心动图与二维斑点追踪成像技术共同评价心肌梗死患者左室收缩功能与同步性

目的探讨二维斑点追踪成像(2D-STI)及实时三维超声心动图(RT-3DE)评价AMI患者左心室收缩功能和各节段运动的同步性.方法 50例急性心肌梗死患者为病例组,30例正常体检者为对照组,应用CMQ软件获取各节段径向圆周应变及应变率曲线,然后转变为RT-3DE模式,得到17节段时间-体积曲线(VTC),并获得收缩功能以及非同步收缩参数.结果 1)与对照组相比,心肌梗死组3个水平所有节段径向应变值和圆周应变值均减低;2)心梗组患者Trs-SD,Tcs-SD,Trsr-SD,Tcsr-SD明显高于对照组(P0.05);3)与单支冠状动脉病变心梗组比较,多支冠状动脉病变心梗组LVEDV,LVESV显著增加,LVEF显著减小;4)病例组患者左室Tmsv17-SD,Tmsv17-Dif,Tmsv17-SD%,Tmsv17-Dif%均较对照组增大(P0.05).结论 RT-3DE和2D-STI可以准确地量化左室收缩功能,评价AMI患者左室运动的同步性,左室收缩功能障碍也影响收缩同步性.     

Empirical likelihood inference for logistic equation with random perturbation

Empirical likelihood (EL) combined with estimating equations (EE) provides a modern semi-parametric alternative to classical estimation techniques such as maximum likelihood estimation (MLE). This paper not only uses closed form of conditional expectation and conditional variance of Logistic equation with random perturbation to perform maximum empirical likelihood estimation (MELE) for the model parameters, but also proposes an empirical likelihood ratio statistic (ELRS) for hypotheses concerning the interesting parameter. Monte Carlo simulation results show that MELE and ELRS provide competitive performance to parametric alternatives.     

Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD

The type III receptor tyrosine kinase FLT3 is frequently mutated in acute myeloid leukemia. Oncogenic FLT3 mutants display constitutive activity leading to aberrant cell proliferation and survival. Phosphorylation on several critical tyrosine residues is known to be essential for FLT3 signaling. Among these tyrosine residues, Y842 is located in the so-called activation loop. The position of this tyrosine residue is well conserved in all receptor tyrosine kinases. It has been reported that phosphorylation of the activation loop tyrosine is critical for catalytic activity for some but not all receptor tyrosine kinases. The role of Y842 residue in FLT3 signaling has not yet been studied. In this report, we show that Y842 is not important for FLT3 activation or ubiquitination but plays a critical role in regulating signaling downstream of the receptor as well as controlling receptor stability. We found that mutation of Y842 in the FLT3-ITD oncogenic mutant background reduced cell viability and increased apoptosis. Furthermore, the introduction of the Y842 mutation in the FLT3-ITD background led to a dramatic reduction in in vitro colony forming capacity. Additionally, mice injected with cells expressing FLT3-ITD/Y842F displayed a significant delay in tumor formation, compared to FLT3-ITD expressing cells. Microarray analysis comparing gene expression regulated by FLT3-ITD versus FLT3-ITD/Y842F demonstrated that mutation of Y842 causes suppression of anti-apoptotic genes. Furthermore, we showed that cells expressing FLT3-ITD/Y842F display impaired activity of the RAS/ERK pathway due to reduced interaction between FLT3 and SHP2 leading to reduced SHP2 activation. Thus, we suggest that Y842 is critical for FLT3-mediated RAS/ERK signaling and cellular transformation.     

大传统与小传统:明清时期鲁西地区的碧霞元君信仰

明清时期鲁西地区是碧霞元君信仰极为盛行的地区,呈现出庙宇数量众多、分布地域广泛等特征.地方官员和士绅对碧霞元君信仰大多持默许和认可态度,并试图借助祀神活动传达官方祭祀理念,进行社会教化.地方官员和士绅关于泰山碧霞元君信仰的不同态度,反映了他们对于地方社会道德秩序的关注,表达了他们试图用官方正统文化去改造民间文化的强烈愿望.相较地方官员和士绅,普通民众崇祀神灵的目的则较为简单,带有显著的世俗性和功利性的特征.在满足其自身信仰需求同时,神灵信仰也起到了增强社会凝聚力、强化地域认同的作用.地方家族也利用重修庙貌、祭祀神灵等手段,实现庙宇与宗族的结合,以此达到增强家族凝聚力和认同感的目的.基于各自不同的目的和需要,官员、士绅和民众共同参与到信仰活动之中,使得信仰在地方社会不断得以延续和传承.     

Isogeometric Analysis-Based Topological Optimization for Heterogeneous Parametric Porous Structures

Porous structures widely exist in nature and artifacts, which can be exploited to reduce structural weight and material usage or improve damage tolerance and energy absorption. In this study,the authors develop an approach to design optimized porous structures with Triply Periodic Minimal Surfaces(TPMSs) in the framework of isogeometric analysis(IGA)-based topological optimization.In the developed method, by controlling the density distribution, the designed porous structures can achieve the opt...     

保持中度生长势成为建筑外表面绿化的选择策略

针对建筑外表面绿化的特殊性提出了中度生长势概念,分析了生长势和绿化寿命的影响因素并提出了概念模型,进一步结合实验探讨了中度生长势的判定.研究结果将补充和丰富城市特殊生境绿化条件下的植物栽培养护理念,为实现节约、可持续的栽培养护模式,延长绿化生命周期提供指导.     

Image separation using wavelet-complex shearlet dictionary

This paper presents a new method for image separation through employing a combined dictionary consisting of wavelets and complex shearlets. Because the combined dictionary sparsely represents points and curvilinear singularities respectively, the image can be decomposed into pointlike and curvelike parts as accurate as possible. The proposed method based on the geo- metric separation theory introduced by Donoho in 2005 shows that accurate geometric separation of the morphologically distinct fea- tures of points and curves can be achieved by l1 minimization. The experimental results show that the proposed method can not only be effective but also greatly reduce the computing time.