Effect of cold rolling process on microstructure and mechanical properties of high strength β titanium alloy thin sheets

The microstructure and mechanical properties of Ti-3.5Al-5Mo-6V-3Cr-2Sn-0.5Fe high strength titanium alloy sheets prepared by unidirectional cold rolling and two-step cross cold rolling were investigated. Results showed that the β phase grains were refined significantly by cold rolling followed by solution treatment for a short time.Compared to unidirectional cold rolling, the short time solution treatment after two-step cross rolling could significantly reduce the non-uniformity of the microstructure of the alloy sheets. After aging treatment at 550 ℃,the anisotropy of the mechanical properties still existed in the unidirectional rolled sheets, and the tensile strength was highest along the rolling direction. After solution and aging treatment, the anisotropy of the mechanical properties of the two-step cross rolling process sheet was not obvious than unidirectional cold rolling,and alloy had good strength and plasticity matching.     

高职生学业成就影响因素的实证研究

以浙江省5所高职院校《大学生心理健康教育》必修课的学生为研究对象,通过目标取向量表、学习策略量表、自我设限策略量表的调研,旨在探讨高职生成就目标取向、学习策略、自我设限及学业成就之间的关系.以研究结果为依据,提出以正确的成就目标为导向,减少自我设限行为,引导学生加强信息处理和元认知策略使用的实施途径.     

Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD

The type III receptor tyrosine kinase FLT3 is frequently mutated in acute myeloid leukemia. Oncogenic FLT3 mutants display constitutive activity leading to aberrant cell proliferation and survival. Phosphorylation on several critical tyrosine residues is known to be essential for FLT3 signaling. Among these tyrosine residues, Y842 is located in the so-called activation loop. The position of this tyrosine residue is well conserved in all receptor tyrosine kinases. It has been reported that phosphorylation of the activation loop tyrosine is critical for catalytic activity for some but not all receptor tyrosine kinases. The role of Y842 residue in FLT3 signaling has not yet been studied. In this report, we show that Y842 is not important for FLT3 activation or ubiquitination but plays a critical role in regulating signaling downstream of the receptor as well as controlling receptor stability. We found that mutation of Y842 in the FLT3-ITD oncogenic mutant background reduced cell viability and increased apoptosis. Furthermore, the introduction of the Y842 mutation in the FLT3-ITD background led to a dramatic reduction in in vitro colony forming capacity. Additionally, mice injected with cells expressing FLT3-ITD/Y842F displayed a significant delay in tumor formation, compared to FLT3-ITD expressing cells. Microarray analysis comparing gene expression regulated by FLT3-ITD versus FLT3-ITD/Y842F demonstrated that mutation of Y842 causes suppression of anti-apoptotic genes. Furthermore, we showed that cells expressing FLT3-ITD/Y842F display impaired activity of the RAS/ERK pathway due to reduced interaction between FLT3 and SHP2 leading to reduced SHP2 activation. Thus, we suggest that Y842 is critical for FLT3-mediated RAS/ERK signaling and cellular transformation.     

水平循环荷载引起的砂土沉陷-致密作用对刚性桩承载力的影响分析

为研究砂土中刚性桩基础在循环荷载作用下的承载力演化规律,提出了一种循环后单桩承载力的评估方法.首先,基于沉陷坑与致密区域土体的质量守恒原理,量化了由沉陷引起的土体参数变化;然后,根据API规范中的砂土水平土抗力-位移模型计算循环前后的单桩承载力;最后,提出了循环后单桩承载力的评估模型,并对沉陷坑尺寸、土体初始相对密实度和致密区域模式等因素进行对比分析.结果 表明:单桩承载力随沉陷坑的发展不断增大;对于松砂、中密砂和密砂,循环后的单桩承载力可分别提高约3.0、1.5、1.2倍,提高幅值随相对密实度的增大而降低;2种土体变形模式中,单锥模式相比于双锥模式更符合真实的致密区域形态.     

Secure Two-Party Distance Computation Protocol Based on Privacy Homomorphism and Scalar Product in Wireless Sensor Networks

Numerous privacy-preserving issues have emerged along with the fast development of the Internet of Things. In addressing privacy protection problems in Wireless Sensor Networks(WSN), secure multi-party computation is considered vital, where obtaining the Euclidian distance between two nodes with no disclosure of either side’s secrets has become the focus of location-privacy-related applications. This paper proposes a novel Privacy-Preserving Scalar Product Protocol(PPSPP) for wireless sensor networks. Based on PPSPP, we then propose a Homomorphic-Encryption-based Euclidean Distance Protocol(HEEDP) without third parties. This protocol can achieve secure distance computation between two sensor nodes. Correctness proofs of PPSPP and HEEDP are provided, followed by security validation and analysis. Performance evaluations via comparisons among similar protocols demonstrate that HEEDP is superior; it is most efficient in terms of both communication and computation on a wide range of data types, especially in wireless sensor networks.     

GLP-1R agonists therapy for type 2 diabetes

Glucagon-like peptide-1 receptor （GLP-1R） agonists are widely used for treating type 2 diabetes mellitus （T2DM） be- cause of their glucose-lowering and weight-losing effects, and low risk of hypoglycemia. Hence, there is considerable interest in understanding the mechanism underlying the beneficial effects of GLP-I and developing stable and effective GLP-1R agonists. Here, we summarize the presently known mechanism of GLP-I actions, which are mainly through regulating cAMP-PKA signaling pathway; the latest developments in novel clinical GLP-1R agonists are also introduced, which are characterized with multiple properties, such as extended half-life, reduced side-effects, lower production costs and more convenient drug dosing mode. The potential risk of GLP-I-based therapeutics, an often-ignored fact, is also discussed.     

科学饮食 营造健康生活

饮食是人类生存的根本,是生命的源泉。伴随着人民生活水平的提高和对餐饮业需求的增长,饮食健康成了一道靓丽的风景。饮食文化、合理膳食、科学烹调和饮食习惯引起了人们广泛关注。     

地方高校“播音与主持艺术专业热”透视

新世纪以来,伴随着“艺考”的升温,中国高等教育出现了前所未有的“播音与主持艺术专业热”.具体表现在开设高校增多、报考学生数量庞大、专业规模迅速膨胀和专业培训红火等方面.专业门槛相对较低、专业收费相对较高、传媒业的迅猛发展、播音与主持人的明星效应等是导致“播音与主持艺术专业热”的主要原因.只有政府、学校、家长、学生共同面对,才能使“播音与主持艺术专业热”降温,从而回归正常轨道.     

地板上尿渍足迹的溴酚蓝溶液新型增强技术研究

目的探索一种新型地板表面尿渍足迹的溴酚蓝酒精溶液增强技术。方法使用BRWY-1雾化器对75%酒精溴酚蓝酒精溶液对地板表面上不同遗留时间和遗留量的尿渍足迹进行溴酚蓝增强处理。结果使用BRWY-1雾化器对75%酒精溴酚蓝溶液雾化喷涂,能够有效增强地板表面上的尿渍足迹,时间约为30 s,尿渍足迹纹线颜色为蓝色,特征清晰连贯、与地板反差明显。结论 BRWY-1雾化器雾化75%酒精溴酚蓝溶液能够有效增强地板表面与尿渍足迹的反差,可作为一种新型尿渍足迹显现和增强技术,有效提高该类痕迹的发现率、提取率和利用率。     

GPSNISNAV integrated relative navigation and attitude determination system for ultra-close spacecraft formation flying

For the improvement of accuracy and better fault-tolerant performance, a global position system (GPS)/vision navigation (VISNAV) integrated relative navigation and attitude determination approach is presented for ultra-close spacecraft formation flying. Onboard GPS and VISNAV system are adopted and a federal Kalman filter architecture is used for the total navigation system design. Simulation results indicate that the integrated system can provide a total improvement of relative navigation and attitude estimation performance in accuracy and fault-tolerance.