A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia

Non-obstructive azoospermia (NOA) is one of the most severe forms of male infertility. Its pathophysiology is largely unknown, and few genetic influences have been defined. To identify common variants contributing to NOA in Han Chinese men, we performed a three-stage genome-wide association study of 2,927 individuals with NOA and 5,734 controls. The combined analyses identified significant (P < 5.0 × 10(-8)) associations between NOA risk and common variants near PRMT6 (rs12097821 at 1p13.3: odds ratio (OR) = 1.25, P = 5.7 × 10(-10)), PEX10 (rs2477686 at 1p36.32: OR = 1.39, P = 5.7 × 10(-12)) and SOX5 (rs10842262 at 12p12.1: OR = 1.23, P = 2.3 × 10(-9)). These findings implicate genetic variants at 1p13.3, 1p36.32 and 12p12.1 in the etiology of NOA in Han Chinese men.     

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.     

支持向量机在围岩变形监测中的应用

根据支特向量机优越的非线性拟合性能,建立变形量的时间序列预测模型,滚动预测围岩变形量,提高了预测模型的训练速度和预测推广能力。该方法用于西乡-固戍盾构段围岩变形预测,并与BP神经网络预测进行比较。结果表明这种模型可预测区间较长且具有较高的准确度,能够科学地指导现场施工和监测。     

Research on intelligent ultrasonic thickness measurement system applied to large area of hull

For a ship in service,seawater corrosion is unavoidable.In order to ensure navigation safety and master the steel plate thickness in service ship,thickness of the ship steel plate must be tested periodically by a scientific method.After consideration of an actual situation of thickness measurement,the bearing mechanism of ultrasonic thickness meter probe has been designed on the basis of wall-climbing robot,and preliminary experiments have been carried out.The device is mainly used for thickness measurement of a large area of ship hull plate when the docking ship has been sandblasted.Efficiency and safety can be improved to finish thickness measurement by using the device.     

An Extension of Gröbner Basis Theory to Indexed Polynomials Without Eliminations

Journal of Systems Science and Complexity - In computer algebra, it remains to be challenging to establish general computational theories for determining the equivalence of indexed polynomials. In...     

In situ backscattered electron imaging study of the effect of annealing on the deformation behaviors of Ni electroformed from additive-free and saccharin-containing sulfamate solutions

The Ni samples were electroformed from additive-free(AF) and saccharin-containing(SC) sulfamate solutions, respectively. In situ backscattered electron(BSE) imaging, electron backscatter diffraction(EBSD), and electron-probe microanalysis(EPMA) were used to investigate the effect of annealing on the deformation behaviors of the AF and SC samples. The results indicate that columnar grains of the as-deposited AF sample had an approximated average width of 3 μm and an approximated aspect ratio of 8. The average width of columnar grains of the as-deposited SC sample was reduced to approximately 400 nm by the addition of saccharin to the electrolyte. A few very-large grains distributed in the matrix of the SC sample after annealing. No direct evidence indicated that S segregated at the grain boundaries before or after annealing. The average value of the total elongations of the SC samples decreased from 16% to 6% after annealing, whereas that of the AF samples increased from 18% to 50%. The dislocation recovery in grain-boundary areas of the annealed AF sample was reduced, which contributed to the appearance of microvoids at the triple junctions. The incompatibility deformation between very-large grains and fine grains contributed to the brittle fracture behavior of the annealed SC Ni.     

用数字波束形成技术测量干扰环境中目标的方向

本文讨论了在干扰环境中利用数字波束形成技术确定目标方向的方法,给出了计算机模拟结果。测量目标角度是基于单脉冲技术中的和差波束的方法。由于各路接收机幅相误差和算法本身的影响,差波束指向零点将产生漂移且零深不够理想,影响了测角精度。本文提出了在差波束的理想指向零点方向用正交化算法产生一零点的办法来校正零点漂移和加深零深,又不影响差方向图的其它性能,从而为用数字波束形成技术精密测角提出了一条路径。另外,本文给出了为消除主瓣干扰而对和差方向图影响的模拟结果。     

基于价值的实验室评估体系构建

现代化实验室的价值取向在于能更好地为教学、科研、生产服务。实验室在长期的教学、科研、生产活动中是否体现了其应有的价值，是衡量实验室建设、管理成败的关键。文中构建了一种基于价值的实验室评估体系模型，以对实验室的价值进行科学的评判。     

一种新型的空调系统空气处理方法及其节能分析

针对现有空调系统空气处理方法存在的不足,提出一种热湿分段的空调系统空气处理方法.分析了热湿分段处理方法的原理和过程,通过建立热湿分段处理方法的节能数学模型,研究并得出了表冷器结构、空调回风状态对热湿分段处理方法节能效果的影响规律.结果表明:相对于常规空气处理方法,热湿分段处理方法在表冷器设计换热温差7 ℃、出风温度为16 ℃时,冷水机组COP提高达9.14%以上;在回风干球温度为25 ℃、湿球温度为21 ℃时,冷水机组COP提高达8%以上.     

普通铁路填石路堤施工工艺参数选定

文章介绍了铜九铁路填石路堤试验段试验,通过对路堤填料粒径、松铺厚度、压实机械及压实遍数等工艺参数分析,制定了填石路基填筑质量控制施工参数,作为控制施工质量的重要指标.