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11.
Danielle Kamato Muhamad Ashraf Rostam Rebekah Bernard Terrence J. Piva Nitin Mantri Daniel Guidone Wenhua Zheng Narin Osman Peter J. Little 《Cellular and molecular life sciences : CMLS》2015,72(4):799-808
G protein-coupled receptor (GPCR) signalling is mediated through transactivation-independent signalling pathways or the transactivation of protein tyrosine kinase receptors and the recently reported activation of the serine/threonine kinase receptors, most notably the transforming growth factor-β receptor family. Since the original observation of GPCR transactivation of protein tyrosine kinase receptors, there has been considerable work on the mechanism of transactivation and several pathways are prominent. These pathways include the “triple membrane bypass” pathway and the generation of reactive oxygen species. The recent recognition of GPCR transactivation of serine/threonine kinase receptors enormously broadens the GPCR signalling paradigm. It may be predicted that the transactivation of serine/threonine kinase receptors would have mechanistic similarities with transactivation of tyrosine kinase pathways; however, initial studies suggest that these two transactivation pathways are mechanistically distinct. Important questions are the relative importance of tyrosine and serine/threonine transactivation pathways, the contribution of transactivation to overall GPCR signalling, mechanisms of transactivation and the range of cell types in which this phenomenon occurs. The ultimate significance of transactivation-dependent signalling remains to be defined but it appears to be prominent and if so will represent a new cell signalling frontier. 相似文献
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LuJian-ke 《武汉大学学报:自然科学英文版》2004,9(1):1-5
The homogeneous quadratic Riemann boundary value problem (1) with Hoelder continuous coefficients for the normal case was considered by the author in 1997. But the solutions obtained there are incomplete. Here its general method of solution is obtained. 相似文献
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Abrupt climate change:Debate or action 总被引:4,自引:1,他引:3
CHENGHai 《科学通报(英文版)》2004,49(18):1997-2002
Global abrupt climate changes have been documented by various climate records, including ice cores, ocean sediment cores, lake sediment cores, cave deposits, loess deposits and pollen records. The climate system prefers to be in one of two stable states, i.e. interstadial or stadial conditions, but not in between. The transition between two states has an abrupt character. Abrupt climate changes are, in general, synchronous in the northern hemisphere and tropical regions. The timescale for abrupt climate changes can be as short as a decade. As the impacts may be potentially serious, we need to take actions such as reducing CO2 emissions to the atmosphere. 相似文献
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RAOLan-lan CAIDong-han 《武汉大学学报:自然科学英文版》2004,9(4):404-406
We prove that the model with physical and human capital adjustment costs has optimal solution when the production function is increasing return and the structure of vetor fields of the model changes substantially when the prodution function from decreasing return turns to increasing return. And it is shown that the economy is improved when the coefficients of adjustment costs become small. 相似文献
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湖南山丘区景观生态系统退化特征初探 总被引:1,自引:1,他引:0
谢炳庚 《湖南师范大学自然科学学报》1997,20(3):80-85
湖南山地丘陵面积约占全省土地总面积的2/3,是省域最重要的景观生态系统类型。自然状态下,湖南山丘区景观生态系统中景观组分性质优良,景观要素组合协调,景观生态过程稳定,景观功能较强。然而,在长期的人类活动影响之下,湖南山丘区景观生态系统显现出明显的退化特征,具有表现为景观要素组合关系改变、景观组分性质劣化、景观生态过程逆转、景观生态系统抗性降低。 相似文献
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用光学显微术研究了奥氏体化温度对30、40、60、T8、T12钢马氏体组织形态的影响。结果表明,奥氏体化温度越高,获得板条马氏体的量越多,奥氏体化温度超过某个临界值时,中高碳钢均可获得全部板条马氏体组织。钢的含碳量越高,获得全部板条马氏体的临界奥氏体温度越高。在该温度以下淬火时,30、40、60钢先形成板条马氏体,后形成片状马氏体;T8、T12钢先形成片状马氏体,后形成板条马氏体 相似文献
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庄子散文大多以丰富多彩的寓言构成。他擅长讲故事,善于刻画人物,文笔辛辣,气势雄伟,意境开阔,笔法多样,行文千变万化,他善于比喻,富于变化,含蓄蕴藉,生动活泼,是中国文学史上的语言大师。 相似文献