孪生组合恒等式(十六)--混合类型

孪生组合恒等式的混合类型简称孪生混合恒等式,这里每个恒等式中包含2种组合记号n与n,获得3组孪生混合恒等式.     

石杉碱甲片联合丁苯酞软胶囊对轻度阿尔茨海默病患者认知功能的疗效观察

目的 评价石杉碱甲片联合丁苯酞软胶囊对阿尔茨海默病患者认知功能的临床疗效.方法 将100例轻度阿尔茨海默病(Alzheimer's disease,AD)患者随机分为石杉碱甲片联合丁苯酞软胶囊组(治疗组)及单独应用石杉碱甲组(对照组).治疗前及治疗90 d后分别评价两组患者简易智力状态检查(Mini-mental St...     

太湖溶藻细菌的分离及评价

从放置于太湖梅梁湾流域的除藻中试装置的人工介质上分离到一株溶藻细菌,经生理、生化和分子生物学鉴定,该株细菌属于芽孢杆菌属.经测定该菌具有较强的溶解铜绿微囊藻和降解微囊藻毒素LR(MC-LR)的功能:该菌(105个/mL)对铜绿微囊藻液(4.5×107个/mL)作用第16,32,48h的溶藻率分别为48%、63%和96%;对MC-LR(2.649μg/L)作用第18,36,54和72h藻毒素降解率分别为15%、29%、73%和100%.应用新建立的实时荧光定量PCR法(RTQ-PCR)对人工介质上的该溶藻芽孢杆菌丰度进行定量检测,结果显示,人工介质上该细菌的丰度约为1%,在7,8,9三个月中呈现递增趋势,其分布具有一定的时空变化规律.     

受荷方式对钢管轻集料混凝土短柱轴压性能的影响

采用3种加载方式对27根钢管轻集料混凝土短柱进行轴压试验,分析了加载方式对构件轴心受压破坏形态和力学性能的影响,主要试验参数为不同轻集料混凝土强度等级和钢管截面尺寸.3种受荷方式分别为:荷载作用在核心混凝土上;荷载作用在整个截面上;采用滚轴加载板将荷载作用在整个截面上.研究结果表明,加载方式对钢管轻集料混凝土短柱的轴压变形性能有较大影响,而对其极限承载力影响不大.无论何种加载方式,钢管轻集料混凝土短柱的纵向压缩变形能力都很强,纵向应变可达0.1,因而具有十分良好的延性,并具有较大的后期承载能力.     

氧化铁纳米颗粒固定化溶藻菌的除藻作用

为了探讨氧化铁纳米颗粒固定化溶藻菌后对铜绿微囊藻的溶藻作用和降解微囊藻毒素LR(MC-LR)的作用,从太湖水体中分离获得一株属于芽孢杆菌属的溶藻菌,将其与氧化铁纳米颗粒固定化后,以普通Fe2O3作为实验对照,测定其溶藻作用和降解MC-LR作用.以激光粒度仪测定氧化铁纳米颗粒与溶藻菌两者单独和同时存在时的粒径大小及粒径分布,以获得氧化铁纳米颗粒固定化溶藻菌的证据.分析结果表明:在太湖水体中分离获得的一株芽孢杆菌具有较强的溶藻和降解MC-LR的作用,作用24 h后的溶藻率和MC-LR降解率分别达到44.3%和20.5%.同时加入氧化铁纳米颗粒后,溶藻率达到53.0%,MC-LR的降解率达到33.0%.激光粒度仪检测发现,氧化铁纳米颗粒与细菌混合后的颗粒物的平均直径增加到氧化铁纳米颗粒的12.3倍,同时氧化铁纳米颗粒和细菌单独存在时的粒径分布峰消失.氧化铁纳米颗粒是一种具有良好性能的生物固定化材料,可能通过其特有的途径有效地固定化溶藻菌,并增强溶藻菌的溶藻和降解藻毒素作用.     

超启发式DE算法求解零等待发酵工艺调度

为解决具备间歇过程特点的零等待发酵工艺调度过程中易变质的难点,提出了一种超启发式差分算法,并将最小化最大完工时间设置为优化目标。此算法分为2层,高层为改进的自适应差分进化算法,来对低层的启发式操作进行选择排序。而低层组合排序成了新的算法对问题域进行操作,加入模拟退火算法避免陷入局部最优。所提出的方法具有学习的机制,对不同问题具有较强的泛化能力。通过测试算例和实际生产进行算法的比较和求解验证了此算法的有效性,结果表明所提出的算法比传统的启发式算法性能更优。     

多重约束下智慧仓储机器人配置仿真优化研究

针对智慧仓库的仓储机器人配置问题,构建了基于排队论的离散事件仿真模型,在保证系统可靠性和服务强度的前提下,考虑到故障对系统的影响,以距离成本、时间成本、空闲成本和购置成本所构成的总成本最小化为目标,提出了一种基于FlexSim平台的离散事件仿真优化方法。通过分析系统平均队长、订单平均逗留时间等指标,将直观化的系统瓶颈与运行实际数据相结合,求得系统成本最小的配置策略。结合实例,对算例中的智慧仓库机器人配置方案进行求解。结果表明,基于FlexSim平台的离散事件仿真寻优方法,能够求解仓储机器人配置的优化方案,并能保证模型方法的计算效率。     

De Casteljau Algorithm and Degree Elevation of Toric Surface Patches

De Casteljau algorithm and degree elevation of Bézier and NURBS curves/surfaces are two important techniques in computer aided geometric design. This paper presents the de Casteljau algorithm and degree elevation of toric surface patches, which include tensor product and triangular rational Bézier surfaces as special cases. Some representative examples of toric surface patches with common shapes are illustrated to verify these two algorithms. Moreover, the authors also apply the degree elevation of toric surface patches to isogeometric analysis. And two more examples show the effectiveness of proposed method.     

A new DFM flow for sub-100nm standard cells

DFM （Design-For-Manufacturability） method, which aims to improve manufacturability of ICs through specific design considerations, is becoming important nowadays. In particular, standard cells now should be designed by DFM method. This paper reports a new DFM flow for sub-100 nm standard cell design with a group of technologies for process modeling, manufacturability simulation and trial RETs. Based on this flow, a set of DFM-friendly 90nm standard cells were designed.     

Mutations in the RNA exosome component gene EXOSC3 cause pontocerebellar hypoplasia and spinal motor neuron degeneration

RNA exosomes are multi-subunit complexes conserved throughout evolution and are emerging as the major cellular machinery for processing, surveillance and turnover of a diverse spectrum of coding and noncoding RNA substrates essential for viability. By exome sequencing, we discovered recessive mutations in EXOSC3 (encoding exosome component 3) in four siblings with infantile spinal motor neuron disease, cerebellar atrophy, progressive microcephaly and profound global developmental delay, consistent with pontocerebellar hypoplasia type 1 (PCH1; MIM 607596). We identified mutations in EXOSC3 in an additional 8 of 12 families with PCH1. Morpholino knockdown of exosc3 in zebrafish embryos caused embryonic maldevelopment, resulting in small brain size and poor motility, reminiscent of human clinical features, and these defects were largely rescued by co-injection with wild-type but not mutant exosc3 mRNA. These findings represent the first example of an RNA exosome core component gene that is responsible for a human disease and further implicate dysregulation of RNA processing in cerebellar and spinal motor neuron maldevelopment and degeneration.