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41.
Sensory deprivation produced by removing the eyes and olfactory bulbs in male rats allowed pinealectomy to markedly augment the post-adrenalectomy elevation of ACTH levels. Pineal removal or sensory deprivation separately did not have this effect. Thus, intact sensory input and an intact pineal gland are independently capable of restricting the post-adrenalectomy rise in ACTH levels. 相似文献
42.
43.
Climate-driven trends in contemporary ocean productivity 总被引:6,自引:0,他引:6
Behrenfeld MJ O'Malley RT Siegel DA McClain CR Sarmiento JL Feldman GC Milligan AJ Falkowski PG Letelier RM Boss ES 《Nature》2006,444(7120):752-755
Contributing roughly half of the biosphere's net primary production (NPP), photosynthesis by oceanic phytoplankton is a vital link in the cycling of carbon between living and inorganic stocks. Each day, more than a hundred million tons of carbon in the form of CO2 are fixed into organic material by these ubiquitous, microscopic plants of the upper ocean, and each day a similar amount of organic carbon is transferred into marine ecosystems by sinking and grazing. The distribution of phytoplankton biomass and NPP is defined by the availability of light and nutrients (nitrogen, phosphate, iron). These growth-limiting factors are in turn regulated by physical processes of ocean circulation, mixed-layer dynamics, upwelling, atmospheric dust deposition, and the solar cycle. Satellite measurements of ocean colour provide a means of quantifying ocean productivity on a global scale and linking its variability to environmental factors. Here we describe global ocean NPP changes detected from space over the past decade. The period is dominated by an initial increase in NPP of 1,930 teragrams of carbon a year (Tg C yr(-1)), followed by a prolonged decrease averaging 190 Tg C yr(-1). These trends are driven by changes occurring in the expansive stratified low-latitude oceans and are tightly coupled to coincident climate variability. This link between the physical environment and ocean biology functions through changes in upper-ocean temperature and stratification, which influence the availability of nutrients for phytoplankton growth. The observed reductions in ocean productivity during the recent post-1999 warming period provide insight on how future climate change can alter marine food webs. 相似文献
44.
HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus 总被引:21,自引:0,他引:21
Altfeld M Allen TM Yu XG Johnston MN Agrawal D Korber BT Montefiori DC O'Connor DH Davis BT Lee PK Maier EL Harlow J Goulder PJ Brander C Rosenberg ES Walker BD 《Nature》2002,420(6914):434-439
Early treatment of acute HIV-1 infection followed by treatment interruptions has shown promise for enhancing immune control of infection. A subsequent loss of control, however, allows the correlates of protective immunity to be assessed. Here we show that sudden breakthrough of plasma viraemia occurred after prolonged immune containment in an individual infected with HIV-1 at a time when 25 distinct CD8+ T-cell epitopes in the viral proteins Gag, RT, Integrase, Env, Nef, Vpr, Vif and Rev were being targeted. Sequencing of the virus in plasma and cells showed that superinfection with a second clade-B virus was coincident with the loss of immune control. This sudden increase in viraemia was associated with a decline in half of the CD8+ T-cell responses. The declining CD8+ T-cell responses were coupled with sequence changes relative to the initial virus that resulted in impaired recognition. Our data show that HIV-1 superinfection can occur in the setting of a strong and broadly directed virus-specific CD8+ T-cell response. The lack of cross-protective immunity for closely related HIV-1 strains, despite persistent recognition of multiple CD8 epitopes, has important implications for public health and vaccine development. 相似文献
45.
Birthday present for digitalis 总被引:1,自引:0,他引:1
46.
F. Carlei J. M. Allen A. E. Bishop S. R. Bloom J. M. Polak 《Cellular and molecular life sciences : CMLS》1985,41(12):1554-1557
Summary Significant quantities of a newly discovered peptide, neuropeptide Y, were found in the rat pancreas, where they were localized to nerves in the exocrine parenchyma and around arterial and ductal structures. Although unaffected by surgical parasympathectomy, the periarterial and periductal nerves were abolished by chemical sympathectomy, suggesting that NPY is partially costored with sympathetic transmitters in nerve fibers. 相似文献
47.
Directed intracellular particle movement is a fundamental process characteristic of all cells. During fast axonal transport, membranous organelles move at rapid rates, from 1 to 5 micron s-1, in either the orthograde or retrograde direction along the neurone and can traverse distances as long as 1 m (for reviews, see refs 1-3). Recent studies indicate that this extreme example of intracellular motility can occur along single microtubules, but the molecules generating the motile force have not been identified or localized. It is not known whether the force-transducing 'motor' is associated with the moving particle or with the microtubule lattice. To distinguish between these hypotheses and to characterize the membrane-cytoskeletal interactions that occur during vesicle translocations, we have developed a reconstituted model for microtubule-based motility. We isolated axoplasmic vesicles from the giant axon of the squid Loligo pealei as described previously. The vesicles (35-475 nm in diameter) were then added to axonemes of Arbacia punctulata spermatozoa that served as a source of microtubules. Axonemes were used because the tubulin subunit lattice of the A-subfibre of a given outer doublet is the same as the subunit lattice of neuronal microtubules along which motility occurs. Moreover, all the microtubules of a single axoneme show the same structural polarity, indicating that the axoneme represents an oriented microtubule substrate. Here we demonstrate that vesicle motility is ATP-dependent, that it is not mediated by the flagellar force-transducing molecule dynein and that the direction of movement is not specified by microtubule polarity. 相似文献
48.
In a greenhouse experiment, effects of nitrogen form and concentration on productivity and dry matter allocation differed between two species native to semiarid ecosystems of the Great Basin. Aboveground production of green surface area and of dry matter were consistently enhanced by increased nitrogen for the rhizomatous grass Elymus lanceolatus , but not for the bunchgrass Oryzopsis hymenoides . These differences were likely due to inherently low growth rates of O. hymenoides . Aboveground dry matter allocation also differed between the two species. O. hymenoides had more leaves per tiller with increased nitrogen, whereas leaf size but not number increased for E. lanceolatus . Furthermore, increases in tiller density with increased nitrogen for E. lanceolatus were almost three times greater than those for O. hymenoides . E. lanceolatus , but not O. hymenoides , was sensitive to the form of nitrogen supplied to the plants. When NH 4 -N was the only form of nitrogen supplied, high concentrations of NH 4 -N inhibited aboveground production of E. lanceolatus . 相似文献
49.
Lepidium papilliferum is an ephemeral species that occupies ""slick spot"" microhabitats in the matrix of sagebrush steppe vegetation of the southwestern Snake River plains, Idaho, USA. We related population demographic data collected from 1993 to 1996 to on-site precipitation data on the Orchard Training Area west of Boise. We also carried out field seed-retrieval and in situ seed bank studies. We found that L. papilliferum has a dual life history strategy. A fraction of each cohort sets seed as summer annuals, while the remaining plants remain vegetative and potentially biennial. Surviving biennials flower and set seed along with the annual cohort of the following year. The switch to flowering as an annual appears to be based on threshold rosette size. Probability of survival to flowering was much lower for biennials than for annuals of the same cohort, but surviving biennials sometimes had enhanced seed production. The summerdry environment of the Snake River plains combined with the slick spot habitat has apparently selected for a primarily summer annual life cycle for this species. Seeds were highly dormant at dispersal and were not responsive to dormancybreaking cues. Those from a given cohort of L. papilliferum remained viable in the soil for at least 11 years. This persistent seed bank provides a buffer against extinction in sequences of years when seed production is low or absent. Estimated seed bank size varied from near zero for a heavily disturbed site that formerly supported the species to 18 viable seeds · dm -2 for an extant population in high-quality habitat. Management for population preservation for L. papilliferum should focus on protecting the seed bank from destruction caused by livestock trampling and other anthropogenic disturbances. 相似文献
50.
Despite the profusion of light in deserts, morphological adaptations to increase light interception are common among desert plants. We studied branch orientation and related physiological parameters in the Mojave Desert Joshua tree, Yucca brevifolia (Agavaceae). Azimuth and inclination were measured on all leaf rosettes of 44 Y. brevifolia trees. Interception of solar radiation was modeled for leaves in hypothetical rosettes facing due south and due north in December, March, and June. Carbon isotope discrimination, nitrogen content, and conductance of water vapor were measured in leaves from north- and south-facing rosettes. Rosette azimuths were nonrandom; rosettes predominantly faced southeast. North-facing rosettes were more steeply inclined than those facing south. The preponderance of south-facing rosettes reduces self-shading and increases interception of solar radiation during the winter-spring growth period. Stomatal conductance was higher for leaves in south-facing than in north-facing rosettes. Nevertheless, discrimination against 13 C was less in leaves of south-facing rosettes, indicating that average intercellular CO 2 concentration was also lower. South-facing whorls had higher leaf nitrogen content. Greater allocation of nitrogen to leaves in south-facing whorls probably results in those leaves having a greater photosynthetic capacity than their north-facing counterparts. Orientation of rosettes to increase interception of sunlight during the period most favorable for photosynthesis, coupled with allocation of nutrients to maintain a higher photosynthetic capacity in those rosettes, should significantly increase whole-plan carbon gain in Y. brevifolia . 相似文献