Reputation helps solve the 'tragedy of the commons'.

The problem of sustaining a public resource that everybody is free to overuse-the 'tragedy of the commons'-emerges in many social dilemmas, such as our inability to sustain the global climate. Public goods experiments, which are used to study this type of problem, usually confirm that the collective benefit will not be produced. Because individuals and countries often participate in several social games simultaneously, the interaction of these games may provide a sophisticated way by which to maintain the public resource. Indirect reciprocity, 'give and you shall receive', is built on reputation and can sustain a high level of cooperation, as shown by game theorists. Here we show, through alternating rounds of public goods and indirect reciprocity games, that the need to maintain reputation for indirect reciprocity maintains contributions to the public good at an unexpectedly high level. But if rounds of indirect reciprocation are not expected, then contributions to the public good drop quickly to zero. Alternating the games leads to higher profits for all players. As reputation may be a currency that is valid in many social games, our approach could be used to test social dilemmas for their solubility.     

Spatial organization of northern flying squirrels, Glaucomys sabrinus: territoriality in females?

We determined home-range overlap among northern flying squirrels ( Glaucomys sabrinus ) to assess their spatial organization. We found extensive home-range overlap among females, and though this overlap could reflect social behavior, we found no evidence of attraction among females, with only one instance of den-sharing. Instead, our results suggest that females share foraging areas but may be territorial in portions of the home range, especially around den trees and during young-rearing. Home-range overlap could also result from the extrinsic effect of forest fragmentation due to timber harvest, which might impede dispersal and force squirrels to cluster on remaining fragments of suitable habitat. Determinamos el sobrelapamiento del rango hogareño entre las ardillas voladoras del norte ( Glaucomys sabrinus ) para evaluar su organización espacial. Encontramos un extenso sobrelapamientos en los rangos hogareños entre las hembras; aunque esto podría reflejar su comportamiento social, no encontramos evidencia de atracción entre hembras, y en sólo un caso compartieron su guarida. Vienen su lugar, nuestros resultados sugieren que las hembras comparten áreas de forrajeo pero pueden ser territoriales en ciertas partes de su rango hogareño, particularmente cerca de los árboles donde tienen guaridas y cuando tienen cría. El sobrelapamiento del rango hogareño también podría ser el resultado del efecto extrínseco de la fragmentación forestal debido a la tala de madera, el cual podría impedir la dispersión y forzar a las ardillas a agruparse en fragmentos de hábitat adecuado que queden.     

Zero-Point Energy: The Case of the Leiden Low-Temperature Laboratory of Heike Kamerlingh Onnes

In this paper we examine the reaction of the Leiden low-temperature laboratory of Heike Kamerlingh Onnes to new ideas in quantum theory. Especially the contributions of Albert Einstein (1906) and Peter Debye (1912) to the theory of specific heat, and the concept of zero-point energy formulated by Max Planck in 1911, gave a boost to solid state research to test these theories. In the case of specific heat measurements, Kamerlingh Onnes's laboratory faced stiff competition from Walter Nernst's Institute of Physical Chemistry in Berlin. In fact, Berlin got the better of it because Leiden lacked focus. After the liquefaction of helium in 1908, Kamerlingh Onnes transformed his laboratory into an international facility for low temperature research, and for this reason it was impossible to make headway with the specific heat measurements. In the case of zero-point energy, Leiden developed a magnetic research programme to test the concept. Initially the balance of evidence seemed to be tipping in favour of zero-point energy. After 1914, however, Leiden would desert the theory in fovour, of a concept from calssical physics. A curious move that illustrates Kamerlingh Onnes's discomfort with the new quantum theory.     

Serologic survey of the island spotted skunk on Santa Cruz Island

Two rare endemic carnivores occur on California's northern Channel Islands: island spotted skunks ( Spilogale gracilis amphiala ) and island foxes ( Urocyon littoralis ). As insular carnivores, both may be particularly vulnerable to novel pathogens. We tested sera from 31 island spotted skunks on Santa Cruz Island, where both skunks and foxes occur sympatrically, to establish their exposure to disease agents. One skunk (3%) tested positive for canine heartworm, and 3 skunks (10%) tested positive for canine parvovirus. None showed evidence of exposure to canine adenovirus, canine distemper virus, canine herpesvirus, Leptospira bacteria (serovars pomona , canicola , and icterohaemorrhagiae ), or pseudorabies virus. Spotted skunks on Santa Cruz Island apparently have low susceptibility or exposure to these pathogens and are unlikely to be reservoirs of these diseases for island foxes.     

Block-Relaxation Approaches for Fitting the INDCLUS Model

A well-known clustering model to represent I?×?I?×?J data blocks, the J frontal slices of which consist of I?×?I object by object similarity matrices, is the INDCLUS model. This model implies a grouping of the I objects into a prespecified number of overlapping clusters, with each cluster having a slice-specific positive weight. An INDCLUS model is fitted to a given data set by means of minimizing a least squares loss function. The minimization of this loss function has appeared to be a difficult problem for which several algorithmic strategies have been proposed. At present, the best available option seems to be the SYMPRES algorithm, which minimizes the loss function by means of a block-relaxation algorithm. Yet, SYMPRES is conjectured to suffer from a severe local optima problem. As a way out, based on theoretical results with respect to optimally designing block-relaxation algorithms, five alternative block-relaxation algorithms are proposed. In a simulation study it appears that the alternative algorithms with overlapping parameter subsets perform best and clearly outperform SYMPRES in terms of optimization performance and cluster recovery.     

In germ cells of mouse embryonic ovaries, the decision to enter meiosis precedes premeiotic DNA replication

The transition from mitosis to meiosis is a defining juncture in the life cycle of sexually reproducing organisms. In yeast, the decision to enter meiosis is made before the single round of DNA replication that precedes the two meiotic divisions. We present genetic evidence of an analogous decision point in the germ line of a multicellular organism. The mouse Stra8 gene is expressed in germ cells of embryonic ovaries, where meiosis is initiated, but not in those of embryonic testes, where meiosis does not begin until after birth. Here we report that in female embryos lacking Stra8 gene function, the early, mitotic development of germ cells is normal, but these cells then fail to undergo premeiotic DNA replication, meiotic chromosome condensation, cohesion, synapsis and recombination. Combined with previous findings, these genetic data suggest that active differentiation of ovarian germ cells commences at a regulatory point upstream of premeiotic DNA replication.     

C-terminal truncations in human 3'-5' DNA exonuclease TREX1 cause autosomal dominant retinal vasculopathy with cerebral leukodystrophy

Autosomal dominant retinal vasculopathy with cerebral leukodystrophy is a microvascular endotheliopathy with middle-age onset. In nine families, we identified heterozygous C-terminal frameshift mutations in TREX1, which encodes a 3'-5' exonuclease. These truncated proteins retain exonuclease activity but lose normal perinuclear localization. These data have implications for the maintenance of vascular integrity in the degenerative cerebral microangiopathies leading to stroke and dementias.     

Homeostatic maintenance of T cells and natural killer cells

Homeostasis in the immune system encompasses the mechanisms governing maintenance of a functional and diverse pool of lymphocytes, thus guaranteeing immunity to pathogens while remaining self-tolerant. Antigen-naïve T cells rely on survival signals through contact with self-peptide-loaded major histocompatibility complex (MHC) molecules plus interleukin (IL)-7. Conversely, antigen-experienced (memory) T cells are typically MHC-independent and they survive and undergo periodic homeostatic proliferation through contact with both IL-7 and IL-15. Also, non-conventional γδ T cells rely on a mix of IL-7 and IL-15 for their homeostasis, whereas natural killer cells are mainly dependent on contact with IL-15. Homeostasis of CD4⁺ T regulatory cells is different in being chiefly regulated by contact with IL-2. Notably, increased levels of these cytokines cause expansion of responsive lymphocytes, such as found in lymphopenic hosts or following cytokine injection, whereas reduced cytokine levels cause a decline in cell numbers.