直觉模糊集所诱导的软集语义及其三支决策

借助于阴影集,利用直觉模糊参数,将直觉模糊集转化为悲观阴影集和乐观阴影集,提出直觉模糊集悲观三支决策和乐观三支决策,给出直觉模糊集诱导软集的方法。利用三支决策理论,提出软集三支决策定性模型。结合直觉模糊集悲观三支决策和乐观三支决策,利用直觉模糊参数,给出软集三支决策定量模型。     

Identification of a new gene mutated in Fraser syndrome and mouse myelencephalic blebs

Fraser syndrome is a recessive, multisystem disorder presenting with cryptophthalmos, syndactyly and renal defects and associated with loss-of-function mutations of the extracellular matrix protein FRAS1. Fras1 mutant mice have a blebbed phenotype characterized by intrauterine epithelial fragility generating serous and, later, hemorrhagic blisters. The myelencephalic blebs (my) strain has a similar phenotype. We mapped my to Frem2, a gene related to Fras1 and Frem1, and showed that a Frem2 gene-trap mutation was allelic to my. Expression of Frem2 in adult kidneys correlated with cyst formation in my homozygotes, indicating that the gene is required for maintaining the differentiated state of renal epithelia. Two individuals with Fraser syndrome were homozygous with respect to the same missense mutation of FREM2, confirming genetic heterogeneity. This is the only missense mutation reported in any blebbing mutant or individual with Fraser syndrome, suggesting that calcium binding in the CALXbeta-cadherin motif is important for normal functioning of FREM2.