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71.
Michael C. Jackson 《Systemic Practice and Action Research》1989,2(1):11-28
The purpose of this paper is to review the ‘assumptional analysis’ methodology developed by R. O. Mason and I. I. Mitroff. The importance of this approach is that it was primarily constructed to deal with ill-structured problems at the strategic level in social systems. The 1980s has seen systems practitioners demonstrating an increased interest in exactly this type of problem. The principles and procedures of the approach are set out, its use in three organisations described, and an assessment of its potential contribution to systems practice provided. 相似文献
72.
This article outlines the methodology and results of the Department of the Environment, Transport and the Regions (DETR) 1996-based household projections for England, and its regions. It examines differences between this round of projections and the previous 1992-based round. The 1996-based projections indicate that between 1996 and 2021 a growth of 3.8 million households can be expected in England, if recent trends continue. Both the national and subnational methodology and results are covered. 相似文献
73.
Insect communication: 'no entry' signal in ant foraging 总被引:1,自引:0,他引:1
Forager ants lay attractive trail pheromones to guide nestmates to food, but the effectiveness of foraging networks might be improved if pheromones could also be used to repel foragers from unrewarding routes. Here we present empirical evidence for such a negative trail pheromone, deployed by Pharaoh's ants (Monomorium pharaonis) as a 'no entry' signal to mark an unrewarding foraging path. This finding constitutes another example of the sophisticated control mechanisms used in self-organized ant colonies. 相似文献
74.
Farmer H McCabe N Lord CJ Tutt AN Johnson DA Richardson TB Santarosa M Dillon KJ Hickson I Knights C Martin NM Jackson SP Smith GC Ashworth A 《Nature》2005,434(7035):917-921
BRCA1 and BRCA2 are important for DNA double-strand break repair by homologous recombination, and mutations in these genes predispose to breast and other cancers. Poly(ADP-ribose) polymerase (PARP) is an enzyme involved in base excision repair, a key pathway in the repair of DNA single-strand breaks. We show here that BRCA1 or BRCA2 dysfunction unexpectedly and profoundly sensitizes cells to the inhibition of PARP enzymatic activity, resulting in chromosomal instability, cell cycle arrest and subsequent apoptosis. This seems to be because the inhibition of PARP leads to the persistence of DNA lesions normally repaired by homologous recombination. These results illustrate how different pathways cooperate to repair damage, and suggest that the targeted inhibition of particular DNA repair pathways may allow the design of specific and less toxic therapies for cancer. 相似文献
75.
Ethylene, the natural regulator of leaf abscission 总被引:1,自引:0,他引:1
Natural leaf fall is triggered by increased ethylene production in senescing cells close to abscission zones. 相似文献
76.
Résumé L'augmentation du fluide du tissu de l'intestin grèle incubé in vitro s'accompagne d'un accroissement du volume des cellules épithéliales. 相似文献
77.
R. Philo A. S. Berkowitz F. L. Jackson J. A. Lloyd J. P. Preslock 《Cellular and molecular life sciences : CMLS》1980,36(12):1425-1426
Summary Procedures designed to express pineal-mediated antigonadotropic activity were performed upon male house mice. Neither blinding nor blinding plus olfactory bulbectomy of house mice resulted in testicular involution within 12 weeks. The pineal gland appears to be of little significance to reproduction in the house mouse.Supported by NICHHD grant No. HDO 7119-092.Supported by NICHHD grant No. 5P5 OHDO 8338.Supported by NSF grant No. SPI 7922 372. 相似文献
78.
79.
Scanning electron microscope studies of human trabecular bone 总被引:1,自引:0,他引:1
80.
Dominant role of the niche in melanocyte stem-cell fate determination 总被引:47,自引:0,他引:47
Nishimura EK Jordan SA Oshima H Yoshida H Osawa M Moriyama M Jackson IJ Barrandon Y Miyachi Y Nishikawa S 《Nature》2002,416(6883):854-860
Stem cells which have the capacity to self-renew and generate differentiated progeny are thought to be maintained in a specific environment known as a niche. The localization of the niche, however, remains largely obscure for most stem-cell systems. Melanocytes (pigment cells) in hair follicles proliferate and differentiate closely coupled to the hair regeneration cycle. Here we report that stem cells of the melanocyte lineage can be identified, using Dct-lacZ transgenic mice, in the lower permanent portion of mouse hair follicles throughout the hair cycle. It is only the population in this region that fulfils the criteria for stem cells, being immature, slow cycling, self-maintaining and fully competent in regenerating progeny on activation at early anagen (the growing phase of hair follicles). Induction of the re-pigmentation process in K14-steel factor transgenic mice demonstrates that a portion of amplifying stem-cell progeny can migrate out from the niche and retain sufficient self-renewing capability to function as stem cells after repopulation into vacant niches. Our data indicate that the niche has a dominant role in the fate determination of melanocyte stem-cell progeny. 相似文献