城市文化环境特质空间分异研究

以大连市甘井子区为例,在城市建成区与郊区的文化环境特质的现状调查基础上,用地理信息系统软件Surfer8.0绘制甘井子区文化环境特质现状等值线图.从区域差异及人群差异角度,研究城市建成区与郊区存在明显的文化环境空间分异,运用因子分析方法对城市郊区人员文化环境偏好分析.研究结果表明:城市郊区对个人精神文化环境关注较少,更重视公共空间文化环境;对制度文化环境关注较少,更重视与生活相关的物质文化环境和行为文化环境.     

关于高等学校学生收费管理体系的探索

针对高等学校办学层次多元化的特点,从学费的收缴方式、催缴手段及学费收缴过程中存在的问题等方面,阐述了高等学校收费管理方式的变革.     

一种时空联合约束的多源航迹相似性度量模型

针对传统方法无法有效度量多源异步航迹时空相似性的问题,该文提出了一种适用于多源异步航迹的相似性度量模型。基于时间和空间联合约束下寻找近似时空特征匹配点的思想,通过设置时间和空间阈值上寻找符合要求的匹配点,并通过空间相似函数度量匹配点的相似性,确定最优匹配点并计算多源航迹间的航迹时空相似度。实测数据表明,该模型可以有效度量异类传感器航迹的相似性,且时间性能较优。基于该模型的航迹关联算法在仿真的复杂多目标环境中的关联准确性优于现有算法,且在对海雷达误差估计中得到了应用。     

数据驱动的技术创新网络模体分析

针对现有技术体系如何实现定量化的网络化建模和识别技术创新的模式和机理两个主要问题,提出数据驱动的技术创新网络构建方法,挖掘出技术文档的关键字向量,结合向量空间模型实现技术相似度的定量计算,生成技术创新时序网络。讨论了技术创新网络基本结构,分析了技术创新网络的模体类型与特性,并计算了模体重要性剖面以进一步确定其网络特征,得出技术创新具有强合作性且技术创新网络与生物网络以及信号传输网络属于同一个网络超家族的结论。并以技术评论数据为例验证了该方法的有效性。     

过程装备与控制工程专业毕业设计教学模式改革

毕业设计是过程装备与控制工程专业本科教学计划的重要组成部分.通过毕业设计,使学生掌握过程装备的设计过程和设计方法,检验学生的综合素质,提高学生解决工程实际问题的能力.按照过程装备与控制工程专业毕业设计现有教学模式的实际情况,针对选题、管理制度、教学资源、设计周期、指导形式、实践环节整合、成果检验以及毕业答辩等方面进行了相应的改革.该研究成果对过程装备与控制工程专业毕业设计的指导工作具有一定的参考价值.     

全面二孩政策下对实施教育、医疗、就业配套措施的研究

全面二孩政策的实施与生殖健康、妇幼保健和入托入学等一系列行业与部门息息相关.通过调查居民二孩生育意愿,从教育、医疗和就业3个方面研究在全面二孩政策下人们产生的新需求,使用RPART分析和方差分析等方法深入分析调查数据,研究如何布局好二孩政策的配套措施,消除居民的生育顾虑,促进二孩政策的推行,解决我国面临的人口老龄化问题,优化人口结构.     

固体化学课程建设的改革与实践

为了培养学生的学习兴趣,提高学生的实践能力和创新能力,在教学过程中加强课程建设,改革教学方法,更新教学手段以及完善考核制度,在近几年的教学实践中取得了良好的效果.     

Metabolic changes during B cell differentiation for the production of intestinal IgA antibody

To sustain the bio-energetic demands of growth, proliferation, and effector functions, the metabolism of immune cells changes dramatically in response to immunologic stimuli. In this review, I focus on B cell metabolism, especially regarding the production of intestinal IgA antibody. Accumulating evidence has implicated not only host-derived factors (e.g., cytokines) but also gut environmental factors, including the possible involvement of commensal bacteria and diet, in the control of B cell metabolism during intestinal IgA antibody production. These findings yield new insights into the regulation of immunosurveillance and homeostasis in the gut.     

Assembly and regulation of ASC specks

The inflammasome adapter ASC links activated inflammasome sensors to the effector molecule pro-caspase-1. Recruitment of pro-caspase-1 to ASC promotes the autocatalytic activation of caspase-1, which leads to the release of pro-inflammatory cytokines, such as IL-1β. Upon triggering of inflammasome sensors, ASC assembles into large helical fibrils that interact with each other serving as a supramolecular signaling platform termed the ASC speck. Alternative splicing, post-translational modifications of ASC, as well as interaction with other proteins can perturb ASC function. In several inflammatory diseases, ASC specks can be found in the extracellular space and its presence correlates with poor prognosis. Here, we review the role of ASC in inflammation, and focus on the structural mechanisms that lead to ASC speck formation, the regulation of ASC function during inflammasome assembly, and the importance of ASC specks in disease.     

Profilin1 biology and its mutation,actin(g) in disease

Profilins were discovered in the 1970s and were extensively studied for their significant physiological roles. Profilin1 is the most prominent isoform and has drawn special attention due to its role in the cytoskeleton, cell signaling, and its link to conditions such as cancer and vascular hypertrophy. Recently, multiple mutations in the profilin1 gene were linked to amyotrophic lateral sclerosis (ALS). In this review, we will discuss the physiological and pathological roles of profilin1. We will further highlight the cytoskeletal function and dysfunction caused by profilin1 dysregulation. Finally, we will discuss the implications of mutant profilin1 in various diseases with an emphasis on its contribution to the pathogenesis of ALS.