略论蜀与滇的文化关系

我国西南地区部族众多,是典型的多民族地区。蜀与滇因为地域相邻,自古以来就关系密切。古蜀可能是西南地区最早创建的一个联盟之国,或称为宗主国。春秋战国时期,古蜀国的东方有巴国与楚国,北方有秦,这些都是当时势力比较强盛的列国。而在同时期的西南夷区域,夜郎与滇等依然是小邦,或者是"邑聚"之类的部族。古蜀国通过商贾与周边少数民族进行贸易以获取资源,此类商贸活动既有短程也有远程,产自于古蜀国的丝绸、青铜器、巴蜀的盐巴,以及其他很多物品,便通过商贸输入了滇国和西南夷地区,有些物品甚至经过远程贸易辗转贩卖到了南亚和中亚。与此同时,古蜀国成熟而高超的青铜铸造技术,也在商周之后随着商贸传入了滇国和西南夷地区。汉武帝大力经略西南夷,到东汉时期西南丝路已成为重要国际通道;后诸葛亮平定南中,有效地促进了汉族和西南各族的团结与融合,其意义是非常深远的。     

The cellular autophagy/apoptosis checkpoint during inflammation

Cell death is a major determinant of inflammatory disease severity. Whether cells live or die during inflammation largely depends on the relative success of the pro-survival process of autophagy versus the pro-death process of apoptosis. These processes interact and influence each other during inflammation and there is a checkpoint at which cells irrevocably commit to either one pathway or another. This review will discuss the concept of the autophagy/apoptosis checkpoint and its importance during inflammation, the mechanisms of inflammation leading up to the checkpoint, and how the checkpoint is regulated. Understanding these concepts is important since manipulation of the autophagy/apoptosis checkpoint represents a novel opportunity for treatment of inflammatory diseases caused by too much or too little cell death.     

Quality control of homologous recombination

Exogenous and endogenous genotoxic agents, such as ionizing radiation and numerous chemical agents, cause DNA double-strand breaks (DSBs), which are highly toxic and lead to genomic instability or tumorigenesis if not repaired accurately and efficiently. Cells have over evolutionary time developed certain repair mechanisms in response to DSBs to maintain genomic integrity. Major DSB repair mechanisms include non-homologous end joining and homologous recombination (HR). Using sister homologues as templates, HR is a high-fidelity repair pathway that can rejoin DSBs without introducing mutations. However, HR execution without appropriate guarding may lead to more severe gross genome rearrangements. Here we review current knowledge regarding the factors and mechanisms required for accomplishment of accurate HR.     

关于机电设备管理问题的分析

机电设备的安全管理是企业中最经常、最大量的安全管理活动,也是企业实现安全目标的基本保证,质量达标是安全生产的保障。因此,加强机电设备监管有着重要的意义。文章就目前机电设备安全管理存在的问题进行了分析。     

Targeting mitochondria by α-tocopheryl succinate overcomes hypoxia-mediated tumor cell resistance to treatment

Rapidly proliferating tumor cells easily become hypoxic. This results in acquired stability towards treatment with anticancer drugs. Here, we show that cells grown at 0.1 % oxygen are more resistant towards treatment with the conventionally used anticancer drugs doxorubicin and cisplatin. The stimulation of apoptosis, as assessed by the number of cells in the SubG1 fraction of the cell cycle, release of cytochrome c into the cytosol, activation of caspase-3, and cleavage of PARP, was markedly suppressed under low oxygen content or when hypoxia was mimicked by deferoxamine. Hypoxia or deferoxamine treatment was accompanied by stabilization of the hypoxia-inducible factor (HIF-1). The downregulation of HIF-1 using siRNA technique restored cell sensitivity to treatment under hypoxic conditions to the levels detected under normoxic conditions. In contrast to cisplatin or doxorubicin, α-tocopheryl succinate (α-TOS), a compound that targets mitochondria, stimulated cell death irrespective of the oxygen concentration. Moreover, under hypoxic condition cell death induced by α-TOS was even enhanced. Thus, α-TOS can successfully overcome resistance to treatment caused by hypoxia, which makes α-TOS an attractive candidate for antitumor therapy via mitochondrial targeting.     

Lysosomal multienzyme complex: pros and cons of working together

The ubiquitous distribution of lysosomes and their heterogeneous protein composition reflects the versatility of these organelles in maintaining cell homeostasis and their importance in tissue differentiation and remodeling. In lysosomes, the degradation of complex, macromolecular substrates requires the synergistic action of multiple hydrolases that usually work in a stepwise fashion. This catalytic machinery explains the existence of lysosomal enzyme complexes that can be dynamically assembled and disassembled to efficiently and quickly adapt to the pool of substrates to be processed or degraded, adding extra tiers to the regulation of the individual protein components. An example of such a complex is the one composed of three hydrolases that are ubiquitously but differentially expressed: the serine carboxypeptidase, protective protein/cathepsin A (PPCA), the sialidase, neuraminidase-1 (NEU1), and the glycosidase β-galactosidase (β-GAL). Next to this ‘core’ complex, the existence of sub-complexes, which may contain additional components, and function at the cell surface or extracellularly, suggests as yet unexplored functions of these enzymes. Here we review how studies of basic biological processes in the mouse models of three lysosomal storage disorders, galactosialidosis, sialidosis, and GM1-gangliosidosis, revealed new and unexpected roles for the three respective affected enzymes, Ppca, Neu1, and β-Gal, that go beyond their canonical degradative activities. These findings have broadened our perspective on their functions and may pave the way for the development of new therapies for these lysosomal storage disorders.     

会计信息失真成因及对策

会计信息失真对经济危害较大,文章从会计信息失真产生的主客观原因进行分析和探讨,并据此提出相应的对策.     

Flame spread over the surface of thermal insulation materials in different environments

Experiments were conducted in a plateau area in Lhasa and a plain area in Hefei China to investigate the flame spread characteristics on thermal insulation materials under different environmental conditions (pressure and oxygen concentration).Molded polystyrene foam (EPS) and extruded polystyrene foam (XPS) samples were placed horizontally on a small-scale flame spread experimental bench.Changes in the average length of the pool fire,flame spread speed,average flame height,and length of preheating zone were used to determine the effect of the plateau and plain environments on flame spread characteristics.These parameters were all larger in Hefei than in Lhasa,which indicates the fire hazard in Hefei will be higher than that in Lhasa if insulation materials of the same size are used.