Cytological detection of mutagen-carcinogen exposure by sister chromatid exchange.

A staining technique that detects sister chromatid exchanges (SCEs) has been used to examine the response of chromosomes in cultured Chinese hamster cells to a wide variety of mutagens-carcinogens. The test gives a very sensitive and rapid method for detecting chromosome mutagenicity of chemical agents and provides a powerful new method for detecting environmental mutagens.     

Gene amplification in oocytes of the rove beetleCreophilus maxillosus (staphylinidae,coleoptera-polyphaga

Summary The extra-DNA body was found, for the first time, in oocytes of an insect with telotrophic ovary. Dispersion of this body is accompanied by an enormous increase of nuclear volume and production of multiple nucleoli. It is suggested that the extra-DNA contains a huge mass of nucleolus organizers.This research was supported in part by funds from the Cytobiology Committee of the Polish Academy of Science.     

The structural relationship of phorbol and cortisol: A possible mechanism for the tumor promoting activity of phorbol

Summary The crucial functional groups of phorbol-12-myristate-13-acetate (PMA) are superimposable with those of the glucocorticoid cortisol in a unique manner which suggests a mechanism for PMA activity, i.e. the alkylation of a cortisol receptor.