Female sex hormones and lysosomal stability in gingival polymorphonuclear leucocytes

Summary In a group of 5 women taking oral contraceptives, the concentration of polymorphonuclear leucocytes along the gingival margin and the activities of cathepsin D, -glucuronidase and elastase were found to increase significantly during the intermenstrual phases.Supported by grant 3.604.075 of the Swiss National Fund for scientific Research. The authors thank Dr M. Baggiolini and Prof. A. Linder for the helpful advices.     

Effects of several preoperative medications on fat cell lipolysis, and activity of adipose tissue cyclic AMP phosphodiesterase.

Effects were examined of atropine, diazepam, pethidene, promethazine, scopolamine, omnopon and papaverine on basal and noradrenaline-stimulated lipolysis in rat isolated fat cells and on rat adipose tissue cyclic AMP phosphodiesterase activity. Papaverine at high concentration (1 mM) inhibited both basal and hormone-stimulated lipolysis, whereas diazepam enhanced basal lipolysis. At a 'clinical dose', omnopon increased both basal and noradrenaline-stimulated lipolysis. Adipose tissue cAMP phosphodiesterase activity was strongly inhibited by 1 mM diazepam, papaverine, promethazine and omnopon (280 microgram ml-1). Lack of enhancement of lipolysis by the established cAMP phosphodiesterase antagonist papaverine, is compatible with simultaneous inhibition also of adipose adenyl cyclase. Diazepam-stimulated lipolysis is compatible with its phosphodiesterase inhibitory activity. It is proposed that papaverine-containing omnopon may offer some survival advantages during surgical stress by facilitating a caloric supply.     

Cerebral neurosecretions and regulation of moulting in a haematophagous insectPanstrongylus megistus, (Heteroptera,Reduviidae)

Summary 2 factors elaborated by distinct neurosecretory cells in the pars intercerebralis control moulting inPanstrongylus megistus. The 1st, originating probably in the A cells, activates the thoracic gland. The 2nd, produced by the A cells, acts at an earlier stage in a different way.Supported by CNPq., Brésil and DGRST (aide No. 76.7.0716).     

Effect of dihydroergocristine infusion on tolbutamide-induced insulin secretion in man

Summary The insulinemic response to 1 g of tolbutamide i.v. is greatly enhanced (+145%) after a 60-min infusion of the -lytic dihydrogenated ergot alkaloid, dihydroergocristine (83.3 m/min, corresponding to a total dose of 5 mg) in 7 healthy subjects. No differences are observed in the glycemic responses.Acknowledgment. The authors are grateful to Mr Franco Della Sala, M.D., for his skillful technical assistance.     

Microwave measurements of the absolute values of absorption by water vapour in the atmosphere

MEASUREMENT of the absolute value of absorption by water vapour at microwave frequencies is difficult because the effect is so small. Far in the wings of the absorption lines, in the so-called 'windows' of the spectrum, it is especially difficult to achieve high accuracy in the free atmosphere. But it is in these windows that the behaviour of the absorption is important from both applied and scientific points of view. Satellite communications, remote sensing of the atmosphere, and radioastronomy, are all influenced by this behaviour. Measurements on an Earth-space path are reported here; the results indicate a nonlinear relationship between absorption and water-vapour content.     

0957 + 561 A, B: twin quasistellar objects or gravitational lens?

0957 + 561 A, B are two QSOs of mag 17 with 5.7 arc s separation at redshift 1.405. Their spectra leave little doubt that they are associated. Difficulties arise in describing them as two distinct objects and the possibility that they are two images of the same object formed by a gravitational lens is discussed.     

Isoprotenerol induction of pineal serotonin N-acetyltransferase in normotensive and spontaneously hypertensive rats

Zusammenfassung Verabreichung von Isoprotenerol, eines -adrenergen Agonisten, induziert einen signifikant höheren Anstieg der Aktivität der Serotonin-N-Acetyltransferase in der Epiphyse von spontan hypertensiven, im Vergleich mit normotensiven, Rattenmännchen. Derselbe Unterschied wurde auch bei Weibchen beobachtet, jedoch liegen die Aktivitätswerte bei spontan hypertensiven Männchen allgemein höher. Die durch Isoprotenerol erhöhte Induktion der Serotonin-N-Acetyltransferase erzeugt hinsichtlich der Catecholamine in den Pinealozyten von spontan hypertensiven Ratten eine veränderte Reaktivität der Achse -Rezeptor-Adenylzyklasesystem-Serotonin-N-Acetyl transferase.