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741.
Stem cells find their niche. 总被引:127,自引:0,他引:127
The concept that stem cells are controlled by particular microenvironments known as 'niches' has been widely invoked. But niches have remained largely a theoretical construct because of the difficulty of identifying and manipulating individual stem cells and their surroundings. Technical advances now make it possible to characterize small zones that maintain and control stem cell activity in several organs, including gonads, skin and gut. These studies are beginning to unify our understanding of stem cell regulation at the cellular and molecular levels, and promise to advance efforts to use stem cells therapeutically. 相似文献
742.
Ion transport proteins must remove an ion's hydration shell to coordinate the ion selectively on the basis of its size and charge. To discover how the K+ channel solves this fundamental aspect of ion conduction, we solved the structure of the KcsA K+ channel in complex with a monoclonal Fab antibody fragment at 2.0 A resolution. Here we show how the K+ channel displaces water molecules around an ion at its extracellular entryway, and how it holds a K+ ion in a square antiprism of water molecules in a cavity near its intracellular entryway. Carbonyl oxygen atoms within the selectivity filter form a very similar square antiprism around each K+ binding site, as if to mimic the waters of hydration. The selectivity filter changes its ion coordination structure in low K+ solutions. This structural change is crucial to the operation of the selectivity filter in the cellular context, where the K+ ion concentration near the selectivity filter varies in response to channel gating. 相似文献
743.
James A. Gessaman 《西北部美国博物学家》2011,44(1)
The weight of body water and fat-free dry weight of Uinta ground squirrels ( Spermophilus armatus ) is given as a function of body weight. Body fat is presented as a function of body weight and body length. An equation for calculating the total caloric content of Uinta ground squirrels is given. Fat index (weight of fat/fat-free dry weight) values of juveniles increased from 0.11 to 0.22 from 5 June to 28 July. In male yearlings and adults the fat index increased about 8 to 9 times in the latter half of June and early July. 相似文献
744.
D. Kendall Brown Anthony A. Echelle David L. Propst James E. Brooks William L. Fisher 《西北部美国博物学家》2011,61(2)
We used the computer program RAMAS to explore the sensitivity of an extinction-risk model for the Gila trout ( Oncorhynchus gilae ) to management of wildfires and number of populations of the species. The Gila trout is an endangered salmonid presently restricted to very few headwaters of the Gila and San Francisco river tributaries in southwestern New Mexico. Life history data for 10 extant populations were used to examine sensitivity of the species viability to changes in a variety of factors including population size, fecundity, life stage structure, number of populations, severity and probability of forest fires, and a regulated fishery. The probability and severity of forest fires and number of populations had the greatest effect on viability. Results indicate that successful conservation of Gila trout requires establishment of additional populations and reduction of the severity of forest fires through a program incorporating more frequent, but less severe, fires. 相似文献
745.
L.J.M. Coleby M.A. M.Sc. Ph.D. 《Annals of science》2013,70(2):101-123
The development of the circular dividing engine in England is traced from Henry Hindley and Jesse Ramsden through the improvements introduced by Ramsden's successors to the self-acting engine of William Simms. Particular emphasis is given to the invention, evolution and transmission of the methods used to achieve accuracy in: dividing the wheel; ratching the teeth and matching them to the endless screw; and mounting the cutter. The procedures adopted by Ramsden and Troughton for correcting initial dividing marks are also described. 相似文献
746.
747.
P.A. Bretscher N. Ismail J.N. Menon C.A. Power J. Uzonna G. Wei 《Cellular and molecular life sciences : CMLS》2001,58(12-13):1879-1896
The occurrence of infectious disease represents a failure of the immune system, a failure that must be prevented by effective vaccination or remedied by treatment. Vaccination against acute diseases such as smallpox and polio are very effective, due to the rapid and increased immune response of vaccinated individuals upon natural infection. In contrast, effective vaccination against intracellular pathogens that cause chronic diseases, such as the leishmaniases, tuberculosis and AIDS, has not been achieved. Clinical observations suggest cell-mediated, Th1 responses, exclusive of antibody production and the generation of Th2 cells, are optimally protective against these intracellular pathogens. Effective vaccination must ensure the generation of such a protective response. We explore here whether understanding very broad features of the regulation of the immune response can accommodate modern findings on the immunological features of these diseases, and provide a perspective within which strategies for effective vaccination and treatment can be developed. 相似文献
748.
749.
Duane A. Tolle 《西北部美国博物学家》2011,37(4)
Normal 0 false false false EN-US X-NONE X-NONE MicrosoftInternetExplorer4 st1\:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} The relative abundance and habitat affinities of breeding and migratory waterfowl were documented for a 16,556 ha (40,880 acre) area of the Navajo Indian Reservation, San Juan County, New Mexico. The objective of the 1973 – 1974 study was to obtain baseline data for use as part of an environmental assessment for coal gasification plants and an associated strip mine proposed for an area not previously described in ornithological journals. Roadside breeding - bird surveys resulted in the observation of 26 species of birds, of which the horned lark was most abundant. Additional breeding - bird observations were made during afternoon reconnaissance surveys around stock ponds and arroyos, and by a helicopter survey of cliff - nesting raptors. Nine of 30 raptor nests located were active. Migratory waterfowl surveys were made in September and November at four stock ponds and a marsh on the study area. Peak waterfowl numbers were present in September, when teal and shovelers were the most abundant species. The importance of stock ponds to breeding and migratory birds and the significance of cliffs to nesting raptors were discussed. Details of observations made for five species of birds designated ";threatened"; or ";status undetermined"; were presented. 相似文献
750.
Streambed surveys were conducted along the upper Colorado River, Colorado, to describe the distributions of Claassenia sabulosa larvae in relation to current speed and to determine their diets. We also addressed diel feeding periodicity by sampling during both day and night. Claassenia sabulosa was more abundant in riffle habitats than in runs. A positive relationship existed between C. sabulosa abundance and stream current, with larval size increasing with current speed. Chironomidae, Baetidae, and Simulidae collectively accounted for 93% of the prey found in stonefly guts; however, these categories were not consumed equally by all C. sabulosa . Smaller C. sabulosa primarily ate chironomids, and larger individuals consumed more baetids. Only a slight difference existed in the percentage of empty guts between night- and day-collected stoneflies, and ranges of prey per gut at night were higher than those in the day, suggesting that these stoneflies may forage more intensively at night. 相似文献