Fuzzy数空间上MS收敛与水平收敛的关系

证明了当u∈E^c，∈E，n=1，2，…时，un^MS→等价于unl→u，并指出条件。∈Ec不能减少．     

VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism

Vascular endothelial growth factor (VEGF) is a principal regulator of blood vessel formation and haematopoiesis, but the mechanisms by which VEGF differentially regulates these processes have been elusive. Here we describe a regulatory loop by which VEGF controls survival of haematopoietic stem cells (HSCs). We observed a reduction in survival, colony formation and in vivo repopulation rates of HSCs after ablation of the VEGF gene in mice. Intracellularly acting small-molecule inhibitors of VEGF receptor (VEGFR) tyrosine kinase dramatically reduced colony formation of HSCs, thus mimicking deletion of the VEGF gene. However, blocking VEGF by administering a soluble VEGFR-1, which acts extracellularly, induced only minor effects. These findings support the involvement in HSC survival of a VEGF-dependent internal autocrine loop mechanism (that is, the mechanism is resistant to inhibitors that fail to penetrate the intracellular compartment). Not only ligands selective for VEGF and VEGFR-2 but also VEGFR-1 agonists rescued survival and repopulation of VEGF-deficient HSCs, revealing a function for VEGFR-1 signalling during haematopoiesis.     

螺旋滚筒选煤机滚圈强度设计方法的研究

介绍了螺旋滚筒选煤机的基本结构和滚圈的作用 ,分析了滚圈的受力 ,建立了力学模型 ,利用求解静不定问题的方法算出特殊截面的内力 ,进而算出滚圈的最大弯矩和截面尺 ,为滚圈设计提供了一种理论方法     

Structure of the dimerized hormone-binding domain of a guanylyl-cyclase-coupled receptor

The atrial natriuretic peptide (ANP) hormone is secreted by the heart in response to an increase in blood pressure. ANP exhibits several potent anti-hypertensive actions in the kidney, adrenal gland and vascular system. These actions are induced by hormone binding extracellularly to the ANP receptor, thereby activating its intracellular guanylyl cyclase domain for the production of cyclic GMP. Here we present the crystal structure of the glycosylated dimerized hormone-binding domain of the ANP receptor at 2.0-A resolution. The monomer comprises two interconnected subdomains, each encompassing a central beta-sheet flanked by alpha-helices, and exhibits the type I periplasmic binding protein fold. Dimerization is mediated by the juxtaposition of four parallel helices, arranged two by two, which brings the two protruding carboxy termini into close relative proximity. From affinity labelling and mutagenesis studies, the ANP-binding site maps to the side of the dimer crevice and extends to near the dimer interface. A conserved chloride-binding site is located in the membrane distal domain, and we found that hormone binding is chloride dependent. These studies suggest mechanisms for hormone activation and the allostery of the ANP receptor.     

浅谈高职院校思想政治教育的创新

高校思想政治教育要克服在落实教育目标过程中的不足,要拓宽教育途径,为了做好高校思想政治教育工作,作者提出了进行观念上的创新、内容上的创新、教育方法上的创新的方法.     

简化稳定广义预测控制算法

讨论了一种简化的无穷广义预测控制算法,算法在被控对象稳定的条件下可以保证闭环系统的稳定性.使用收缩原开环系统极点的方法使原系统稳定,然后针对这个稳定广义系统推导了无穷广义预测控制率,理论分析证明可以保证开环不稳定系统的闭环稳定性.该算法可以得到控制率的显式解,不用递推求解Diophantine方程,大大减小了过程计算量,具有一个意义明确的可调参数,适用于不稳定,非最小相位和纯滞后系统.对几类不稳定过程的数值仿真结果说明了该方法的有效性.     

嗜热硫氧化硫化杆菌一新菌株的分离与鉴定

从云南腾冲酸性热泉富集物中分离到一株适度嗜热喜酸菌YN22.该菌革兰氏染色阳性,直杆状或微弯,长约1.6~2.8μm,直径0.4~0.7μm.该菌能在25~60℃下生长,最适生长温度为53℃;生长pH为1.0~5.0,最适pH为1.5;化能自养型,0.025%(w/V)的酵母提取物对其生长有明显的促进作用,在酵母提取物存在的情况下能快速氧化Fe2 ,但对S0和还原型硫化物的氧化能力较低.16s rDNA系统发育分析表明,该菌与嗜热硫氧化硫化杆菌(Sulfobacillus thermosulfidooxidans)的16s rDNA序列相似性达99%.YN22基因组DNA的G C含量为47.3 mol%,与嗜热硫氧化硫化杆菌模式菌株VKM B-1 269非常接近,后者基因组DNA的G C含量为47.5 mol%.基于形态特征、生理生化特性、系统发育学和G C含量的分析结果,YN22应归于硫化杆菌属(Sulfobacillus),为嗜热硫氧化硫化杆菌(Sb.thermosulfidooxidans)的一新菌株.这是国内首次分离,并经多种方法鉴定、确认的嗜热硫氧化硫化杆菌,从而为我国浸矿微生物的基础和应用研究提供了最典型的适度嗜热菌种.     

欧盟竞争法“基础设施原则”司法实践研究

在欧盟的法律秩序当中,欧盟法院担任着一个关键的角色,通过其判决持续地为欧盟的法律秩序强化司法的保护。在公共服务业的各种限制竞争行为中,滥用优势地位是其主要的表现形式。20世纪90年代欧盟竞争法的显著发展之一就是出现了"基础设施原则"(EFD)这一重要法律规定,而这一时期欧共体法院的司法判例有着深远的影响。     

考虑时滞影响的分层非线性全局控制器的设计

提出了基于广域信息的分层控制器结构,第一层是负责计算全局信息（如功角中心、角速度中心）的广域控制器,第二层是将本地测量信号与全局信息相结合以得到控制规律的本地控制器.同时,为了克服基于线性二次调节的非线性全局控制器易受时滞影响的弊端,应用线性矩阵不等式的H∞控制理论提出了新的计及时滞影响的非线性全局综合控制器.四机系统的仿真结果表明,当考虑广域信息的时滞影响时,该控制器仍能快速平息系统的振荡,提高系统的稳定性.