全文获取类型
收费全文 | 370篇 |
免费 | 2篇 |
国内免费 | 1篇 |
专业分类
系统科学 | 6篇 |
丛书文集 | 1篇 |
理论与方法论 | 1篇 |
现状及发展 | 38篇 |
研究方法 | 64篇 |
综合类 | 238篇 |
自然研究 | 25篇 |
出版年
2021年 | 1篇 |
2020年 | 1篇 |
2017年 | 4篇 |
2016年 | 4篇 |
2015年 | 3篇 |
2014年 | 8篇 |
2013年 | 5篇 |
2012年 | 41篇 |
2011年 | 60篇 |
2010年 | 10篇 |
2009年 | 1篇 |
2008年 | 33篇 |
2007年 | 43篇 |
2006年 | 37篇 |
2005年 | 26篇 |
2004年 | 25篇 |
2003年 | 23篇 |
2002年 | 31篇 |
2001年 | 1篇 |
2000年 | 1篇 |
1999年 | 2篇 |
1998年 | 1篇 |
1997年 | 2篇 |
1994年 | 1篇 |
1992年 | 1篇 |
1990年 | 2篇 |
1989年 | 2篇 |
1988年 | 1篇 |
1984年 | 1篇 |
1976年 | 1篇 |
1965年 | 1篇 |
排序方式: 共有373条查询结果,搜索用时 62 毫秒
371.
Kidd JM Cooper GM Donahue WF Hayden HS Sampas N Graves T Hansen N Teague B Alkan C Antonacci F Haugen E Zerr T Yamada NA Tsang P Newman TL Tüzün E Cheng Z Ebling HM Tusneem N David R Gillett W Phelps KA Weaver M Saranga D Brand A Tao W Gustafson E McKernan K Chen L Malig M Smith JD Korn JM McCarroll SA Altshuler DA Peiffer DA Dorschner M Stamatoyannopoulos J Schwartz D Nickerson DA Mullikin JC Wilson RK Bruhn L Olson MV Kaul R Smith DR Eichler EE 《Nature》2008,453(7191):56-64
Genetic variation among individual humans occurs on many different scales, ranging from gross alterations in the human karyotype to single nucleotide changes. Here we explore variation on an intermediate scale--particularly insertions, deletions and inversions affecting from a few thousand to a few million base pairs. We employed a clone-based method to interrogate this intermediate structural variation in eight individuals of diverse geographic ancestry. Our analysis provides a comprehensive overview of the normal pattern of structural variation present in these genomes, refining the location of 1,695 structural variants. We find that 50% were seen in more than one individual and that nearly half lay outside regions of the genome previously described as structurally variant. We discover 525 new insertion sequences that are not present in the human reference genome and show that many of these are variable in copy number between individuals. Complete sequencing of 261 structural variants reveals considerable locus complexity and provides insights into the different mutational processes that have shaped the human genome. These data provide the first high-resolution sequence map of human structural variation--a standard for genotyping platforms and a prelude to future individual genome sequencing projects. 相似文献
372.
S Seshagiri EW Stawiski S Durinck Z Modrusan EE Storm CB Conboy S Chaudhuri Y Guan V Janakiraman BS Jaiswal J Guillory C Ha GJ Dijkgraaf J Stinson F Gnad MA Huntley JD Degenhardt PM Haverty R Bourgon W Wang H Koeppen R Gentleman TK Starr Z Zhang DA Largaespada TD Wu FJ de Sauvage 《Nature》2012,488(7413):660-664
373.
Effect of remote sea surface temperature change on tropical cyclone potential intensity 总被引:5,自引:0,他引:5
The response of tropical cyclone activity to global warming is widely debated. It is often assumed that warmer sea surface temperatures provide a more favourable environment for the development and intensification of tropical cyclones, but cyclone genesis and intensity are also affected by the vertical thermodynamic properties of the atmosphere. Here we use climate models and observational reconstructions to explore the relationship between changes in sea surface temperature and tropical cyclone 'potential intensity'--a measure that provides an upper bound on cyclone intensity and can also reflect the likelihood of cyclone development. We find that changes in local sea surface temperature are inadequate for characterizing even the sign of changes in potential intensity, but that long-term changes in potential intensity are closely related to the regional structure of warming; regions that warm more than the tropical average are characterized by increased potential intensity, and vice versa. We use this relationship to reconstruct changes in potential intensity over the twentieth century from observational reconstructions of sea surface temperature. We find that, even though tropical Atlantic sea surface temperatures are currently at a historical high, Atlantic potential intensity probably peaked in the 1930s and 1950s, and recent values are near the historical average. Our results indicate that--per unit local sea surface temperature change--the response of tropical cyclone activity to natural climate variations, which tend to involve localized changes in sea surface temperature, may be larger than the response to the more uniform patterns of greenhouse-gas-induced warming. 相似文献