全文获取类型
收费全文 | 421篇 |
免费 | 0篇 |
国内免费 | 1篇 |
专业分类
系统科学 | 5篇 |
教育与普及 | 1篇 |
理论与方法论 | 2篇 |
现状及发展 | 64篇 |
研究方法 | 112篇 |
综合类 | 230篇 |
自然研究 | 8篇 |
出版年
2021年 | 5篇 |
2020年 | 1篇 |
2018年 | 8篇 |
2017年 | 6篇 |
2016年 | 3篇 |
2015年 | 2篇 |
2014年 | 1篇 |
2013年 | 5篇 |
2012年 | 44篇 |
2011年 | 52篇 |
2010年 | 14篇 |
2009年 | 2篇 |
2008年 | 27篇 |
2007年 | 40篇 |
2006年 | 38篇 |
2005年 | 34篇 |
2004年 | 31篇 |
2003年 | 21篇 |
2002年 | 26篇 |
2001年 | 5篇 |
2000年 | 4篇 |
1999年 | 2篇 |
1992年 | 2篇 |
1991年 | 5篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1983年 | 2篇 |
1980年 | 1篇 |
1978年 | 1篇 |
1976年 | 4篇 |
1974年 | 3篇 |
1973年 | 1篇 |
1972年 | 3篇 |
1971年 | 3篇 |
1970年 | 5篇 |
1969年 | 6篇 |
1968年 | 2篇 |
1967年 | 1篇 |
1966年 | 2篇 |
1957年 | 1篇 |
1955年 | 2篇 |
排序方式: 共有422条查询结果,搜索用时 0 毫秒
421.
The mammalian hair follicle is a complex 'mini-organ' thought to form only during development; loss of an adult follicle is considered permanent. However, the possibility that hair follicles develop de novo following wounding was raised in studies on rabbits, mice and even humans fifty years ago. Subsequently, these observations were generally discounted because definitive evidence for follicular neogenesis was not presented. Here we show that, after wounding, hair follicles form de novo in genetically normal adult mice. The regenerated hair follicles establish a stem cell population, express known molecular markers of follicle differentiation, produce a hair shaft and progress through all stages of the hair follicle cycle. Lineage analysis demonstrated that the nascent follicles arise from epithelial cells outside of the hair follicle stem cell niche, suggesting that epidermal cells in the wound assume a hair follicle stem cell phenotype. Inhibition of Wnt signalling after re-epithelialization completely abrogates this wounding-induced folliculogenesis, whereas overexpression of Wnt ligand in the epidermis increases the number of regenerated hair follicles. These remarkable regenerative capabilities of the adult support the notion that wounding induces an embryonic phenotype in skin, and that this provides a window for manipulation of hair follicle neogenesis by Wnt proteins. These findings suggest treatments for wounds, hair loss and other degenerative skin disorders. 相似文献
422.
Saarela JM Rai HS Doyle JA Endress PK Mathews S Marchant AD Briggs BG Graham SW 《Nature》2007,446(7133):312-315
Although the relationship of angiosperms to other seed plants remains controversial, great progress has been made in identifying the earliest extant splits in flowering-plant phylogeny, with the discovery that the New Caledonian shrub Amborella trichopoda, the water lilies (Nymphaeales), and the woody Austrobaileyales constitute a basal grade of lines that diverged before the main radiation in the clade. By focusing attention on these ancient lines, this finding has re-written our understanding of angiosperm structural and reproductive biology, physiology, ecology and taxonomy. The discovery of a new basal lineage would lead to further re-evaluation of the initial angiosperm radiation, but would also be unexpected, as nearly all of the approximately 460 flowering-plant families have been surveyed in molecular studies. Here we show that Hydatellaceae, a small family of dwarf aquatics that were formerly interpreted as monocots, are instead a highly modified and previously unrecognized ancient lineage of angiosperms. Molecular phylogenetic analyses of multiple plastid genes and associated noncoding regions from the two genera of Hydatellaceae identify this overlooked family as the sister group of Nymphaeales. This surprising result is further corroborated by evidence from the nuclear gene phytochrome C (PHYC), and by numerous morphological characters. This indicates that water lilies are part of a larger lineage that evolved more extreme and diverse modifications for life in an aquatic habitat than previously recognized. 相似文献