农村中小学教师队伍建设之三维分析

农村中小学教师素质整体偏低掣肘着我国农村教育的长足发展。文章从提高教师待遇、改善教师生活条件,创新与完善农村教师补充机制,开展多样化农村教师培训等三个维度分析国家及地方政府在提高农村中小学教师整体素质时采取的积极举措,同时予以案例说明,以期为尚在探索当地农村教师队伍建设的地区提供借鉴。     

实践转向与中国特色当代美学构建

建设中国特色当代美学几乎已成为中国当代美学界的一种共识.这种共识实际上是马克思主义的“现代实践转向”和20世纪90年代的“后现代实践转向”的共同结果.“现代实践转向”在中国奠定了以马克思主义实践观为基础的实践美学,并且,在20世纪80年,代实践美学成了中国当代美学的主导流派.随着20世纪90年代后现代主义思潮传入中国,“后现代实践转向”又打破了实践美学的唯我独尊的地位,形成了中国当代美学的多元共存的开放局面.在实践美学与后实践美学的论争中,实践美学发展到新的阶段,新实践美学依然一枝独秀,可能成为中国特色美学中的核心流派,并以“后现代实践转向”的发散性思维和多元共存的实践,建设中国特色当代美学.其中,以中国传统美学的优秀遗产为根基,以马克思主义实践观为指导,以西方美学发展为参照系,建设新实践美学,就是一个主要维度或多元共存中的主要“一元”.     

建筑结构设计软件动力时程分析功能比较

利用SATWE、MIDAS/Building和ETABS软件分别对结构地震作用进行计算以获得其在地震作用下的反应,来判断结构整体的安全性和可靠性.对3种软件在前处理、分析过程中、后处理3方面进行对比,得出在前处理中MIDAS/Building在建模、选波和调波方面具有一定的优势,并且在后处理方面提供了丰富的后处理功能,便于操作人员快速查询结果.     

GLP-1R agonists therapy for type 2 diabetes

Glucagon-like peptide-1 receptor （GLP-1R） agonists are widely used for treating type 2 diabetes mellitus （T2DM） be- cause of their glucose-lowering and weight-losing effects, and low risk of hypoglycemia. Hence, there is considerable interest in understanding the mechanism underlying the beneficial effects of GLP-I and developing stable and effective GLP-1R agonists. Here, we summarize the presently known mechanism of GLP-I actions, which are mainly through regulating cAMP-PKA signaling pathway; the latest developments in novel clinical GLP-1R agonists are also introduced, which are characterized with multiple properties, such as extended half-life, reduced side-effects, lower production costs and more convenient drug dosing mode. The potential risk of GLP-I-based therapeutics, an often-ignored fact, is also discussed.     

芜湖市房地产行业景气指数建模与预测研究

通过X-11过程消除季节因素和同比法消除量纲影响,并采用因子分析法加权编制"芜房指数";采用数理统计的方法对"芜房指数"分析建立预警系统,通过与实际情况对比,表明预警系统是有效的。建立"芜房指数"的预测模型,结合预警系统分级与七个指标的分类指数,拟合出有效的定序回归模型,根据近年来的"芜房指数"序列建立ARMA模型,并对后五期的"芜房指数"作了有效的预测。     

影响螺纹副轴向力分布均匀性的关键因素分析

通过对螺纹连接结构承载分布问题的理论分析与数值模拟,探索影响螺纹副轴向力分布均匀性的关键因素.首先对螺纹副轴向承载分布进行理论分析,提出依据螺纹副截面上单位长度荷载F与螺纹牙相对变形u的关系曲线确定轴向力分布的解析方法.理论分析表明,当F-u关系曲线呈屈服形状时,螺纹副轴向承载力分布更加均匀.其次,对施必牢螺纹副进行分析,发现其F-u关系曲线呈现出屈服特征;从牙型设计、材料塑性和螺纹错动三方面进行分析,阐明施必牢螺纹副承载分布均匀性好的力学机制;最后,详细分析了螺纹副径向尺寸系数、摩擦因数和材料特性等因素对螺纹上轴向力分布的影响规律.     

Collaborative Project Management: A Systemic Approach to Heavy Equipment Manufacturing Project Management

Quite often over the last decade, heavy equipment manufacturers are trying to improve their project management performance with the use of effective project management methods. However, the challenges encountered aren’t isolated problems and a systemic approach is required. This paper exemplifies how a systemic approach can be applied to heavy equipment manufacturing project (HEMP) management, through of a multifaceted vision. The findings present in the paper are based on a two-year case study in a metallurgic equipment manufacturing enterprise in China. Based on the analysis of HEMP management problems and the contributions on systemic approach application in project management, the paper enriches existing theory by: (1) interpreting the HEMP management system with the top-down disassembly method; (2) developing the collaborative project management approach with a systems view highlighting the project characteristics management and inter-departmental collaboration; (3) making suggestions for systemic approach application in project management. For practitioners and researchers, the findings are particularly meaningful for manufacturing project management and systemic approach application.     

略论蜀与滇的文化关系

我国西南地区部族众多,是典型的多民族地区。蜀与滇因为地域相邻,自古以来就关系密切。古蜀可能是西南地区最早创建的一个联盟之国,或称为宗主国。春秋战国时期,古蜀国的东方有巴国与楚国,北方有秦,这些都是当时势力比较强盛的列国。而在同时期的西南夷区域,夜郎与滇等依然是小邦,或者是"邑聚"之类的部族。古蜀国通过商贾与周边少数民族进行贸易以获取资源,此类商贸活动既有短程也有远程,产自于古蜀国的丝绸、青铜器、巴蜀的盐巴,以及其他很多物品,便通过商贸输入了滇国和西南夷地区,有些物品甚至经过远程贸易辗转贩卖到了南亚和中亚。与此同时,古蜀国成熟而高超的青铜铸造技术,也在商周之后随着商贸传入了滇国和西南夷地区。汉武帝大力经略西南夷,到东汉时期西南丝路已成为重要国际通道;后诸葛亮平定南中,有效地促进了汉族和西南各族的团结与融合,其意义是非常深远的。     

Physical layer impairments tolerance based lightpath provision in software defined optical network

As all-optical networks grow with ever increasing ultra-high speed, the communication quality suffers seriously from physical layer impairments ( PLIs) .The same problem still exists in software defined optical network ( SDON) controlled by OpenFlow.Aimed to solve this problem, a PLIs tol-erance based lightpath provision scheme is proposed for OpenFlow controlled optical networks.This proposed approach not only takes the OSNR model to represent those linear PLIs factors, but also in-troduces those nonlinear factors into the OSNR model.Thus, the proposed scheme is able to cover most PLIs factors of each optical link and conduct optical lightpath provison with better communica-tion quality.Moreover, PLIs tolerance model is also set up and considered in this work with some necessary extension to OpenFlow protocols to achieve better compatibility between physical layer im-pairments factors and various services connections.Simulation results show that the proposed scheme is able to get better performance in terms of packet loss rate and connection setup time.     

Quality control of homologous recombination

Exogenous and endogenous genotoxic agents, such as ionizing radiation and numerous chemical agents, cause DNA double-strand breaks (DSBs), which are highly toxic and lead to genomic instability or tumorigenesis if not repaired accurately and efficiently. Cells have over evolutionary time developed certain repair mechanisms in response to DSBs to maintain genomic integrity. Major DSB repair mechanisms include non-homologous end joining and homologous recombination (HR). Using sister homologues as templates, HR is a high-fidelity repair pathway that can rejoin DSBs without introducing mutations. However, HR execution without appropriate guarding may lead to more severe gross genome rearrangements. Here we review current knowledge regarding the factors and mechanisms required for accomplishment of accurate HR.