相似产品步进应力加速寿命试验的统计分析

本文将单组样本的步进应力加速寿命试验(SSALT)拓展到双样本情形.基于累积失效模型(CEM),对两组指数产品的联合Ⅱ型截尾数据进行综合分析.首先,计算未知参数的极大似然估计(MLE),并利用矩母函数(MGF)建立其条件概率分布.然后,采用两种方法,基于概率分布的精确分析方法和参数的Bootstrap方法,构建参数的置信区间(CIs).以覆盖率作为评价标准,对两种方法的区间估计效果进行分析.最后,通过数值算例验证了本文方法的有效性.     

基于专利引文数据的混合动力汽车创新扩散研究

以巴斯扩散模型为理论基础,利用1995～2011年的专利引文数据,对混合动力汽车的技术扩散模型进行了非线性最小二乘法估计。结果显示：①各参数均为统计上显著的,且可决系数与调整可决系数均较大;②该技术的扩散路径符合巴斯模型,且处于成熟阶段。同时,以普锐斯为例,对其1997～2010年的销售数据进行拟合与预测,结果显示,该产品的扩散过程符合巴斯模型。文章认为新技术的扩散与新产品之间存在时滞。     

MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis

Disruption of signaling pathways such as those mediated by sonic hedgehog (Shh) or platelet-derived growth factor (Pdgf) causes craniofacial abnormalities, including cleft palate. The role that microRNAs play in modulating palatogenesis, however, is completely unknown. We show that, in zebrafish, the microRNA Mirn140 negatively regulates Pdgf signaling during palatal development, and we provide a mechanism for how disruption of Pdgf signaling causes palatal clefting. The pdgf receptor alpha (pdgfra) 3' UTR contained a Mirn140 binding site functioning in the negative regulation of Pdgfra protein levels in vivo. pdgfra mutants and Mirn140-injected embryos shared a range of facial defects, including clefting of the crest-derived cartilages that develop in the roof of the larval mouth. Concomitantly, the oral ectoderm beneath where these cartilages develop lost pitx2 and shha expression. Mirn140 modulated Pdgf-mediated attraction of cranial neural crest cells to the oral ectoderm, where crest-derived signals were necessary for oral ectodermal gene expression. Mirn140 loss of function elevated Pdgfra protein levels, altered palatal shape and caused neural crest cells to accumulate around the optic stalk, a source of the ligand Pdgfaa. These results suggest that the conserved regulatory interactions of mirn140 and pdgfra define an ancient mechanism of palatogenesis, and they provide candidate genes for cleft palate.     

注塑机注射速度的模糊控制及其仿真

注射速度控制是注塑成型工艺里极其重要的一环。由于注塑过程的时变和非线性特点,注射速度控制成为较为复杂的一个课题。在一个螺杆往返式注塑机通用模型的基础上,给出了注塑机速度模糊控制系统的一般性设计方法:输入输出量定义域的选择,隶属度函数的形状,使用相位面分析设计知识库,前馈控制器的设计。通过仿真说明了该方法设计的控制系统能有效的跟踪快速变化的速度设定曲线,在模型参数发生变化时也能够得到良好的控制效果。     

一种基于随机进程代数的软件性能预测方法

性能是软件系统的内在属性之一,主要取决于体系结构选择和软件设计.基于模型的性能预测方法可以在软件开发完毕前得到性能需求满足情况的评价,也可帮助系统进行性能规划和调优.使用随机进程代数PEPA对J2EE应用交互过程进行了建模,该模型描绘了远程调用过程和容器处理过程的细节,能有效反映分布式应用中影响性能的主要因素.基于PEPA模型提出了一种面向COTS系统的性能预测方法,并可用于指导改进系统的响应性和可伸缩性.通过一个J2EE实例验证了方法的有效性.     

Volterra series based predistortion for broadband RF power amplifiers with memory effects

RF power amplifiers(PAs)are usually considered as memoryless devices in most existing predistortion techniques.However,in broadband communication systems,such as WCDMA,the PA memory effects are significant,and memoryless predistortion cannot linearize the PAs effectively.After analyzing the PA memory effects,a novel predistortion method based on the simplified Volterra series is proposed to linearize broadband RF PAs with memory effects.The indirect learning architecture is adopted to design the predistortion scheme and the recursive least squares algorithm with forgetting factor is applied to identify the parameters of the predistorter.Simulation results show that the proposed predistortion method can compensate the nonlinear distortion and memory effects of broadband RF PAs effectively.     

Rough function model and rough membership function

Two pairs of approximation operators, which are the scale lower and upper approximations as well as the real line lower and upper approximations, are defined. Their properties and antithesis characteristics are analyzed. The rough function model is generalized based on rough set theory, and the scheme of rough function theory is made more distinct and complete. Therefore, the transformation of the real function analysis from real line to scale is achieved. A series of basic concepts in rough function model including rough numbers, rough intervals, and rough membership functions are defined in the new scheme of the rough function model. Operating properties of rough intervals similar to rough sets are obtained. The relationship of rough inclusion and rough equality of rough intervals is defined by two kinds of tools, known as the lower （upper） approximation operator in real numbers domain and rough membership functions. Their relative properties are analyzed and proved strictly, which provides necessary theoretical foundation and technical support for the further discussion of properties and practical application of the rough function model.     

复杂性研究的计算方法

计算、算法与复杂性研究有着密切的关系,计算方法已经上升为一种复杂性研究的科学方法。计算复杂性使用的研究方法基本上是计算方法,算法复杂性研究的算法描述也是一种计算方法。计算方法还在复杂适应系统理论、人工生命等复杂性分支学科中扮演了重要的角色。计算方法不但在复杂性研究中有重要的作用,而且在一般方法论意义上也已经变得不可或缺,甚至走向了计算主义。     

Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation

Epigenetic silencing in cancer cells is mediated by at least two distinct histone modifications, polycomb-based histone H3 lysine 27 trimethylation (H3K27triM) and H3K9 dimethylation. The relationship between DNA hypermethylation and these histone modifications is not completely understood. Using chromatin immunoprecipitation microarrays (ChIP-chip) in prostate cancer cells compared to normal prostate, we found that up to 5% of promoters (16% CpG islands and 84% non-CpG islands) were enriched with H3K27triM. These genes were silenced specifically in prostate cancer, and those CpG islands affected showed low levels of DNA methylation. Downregulation of the EZH2 histone methyltransferase restored expression of the H3K27triM target genes alone or in synergy with histone deacetylase inhibition, without affecting promoter DNA methylation, and with no effect on the expression of genes silenced by DNA hypermethylation. These data establish EZH2-mediated H3K27triM as a mechanism of tumor-suppressor gene silencing in cancer that is potentially independent of promoter DNA methylation.     

Male-pattern baldness susceptibility locus at 20p11

We conducted a genome-wide association study for androgenic alopecia in 1,125 men and identified a newly associated locus at chromosome 20p11.22, confirmed in three independent cohorts (n = 1,650; OR = 1.60, P = 1.1 x 10(-14) for rs1160312). The one man in seven who harbors risk alleles at both 20p11.22 and AR (encoding the androgen receptor) has a sevenfold-increased odds of androgenic alopecia (OR = 7.12, P = 3.7 x 10(-15)).