Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1.

Neurofibromatosis type I (NF1) is one of the most common single-gene disorders that causes learning deficits in humans. Mice carrying a heterozygous null mutation of the Nfl gene (Nfl(+/-) show important features of the learning deficits associated with NF1 (ref. 2). Although neurofibromin has several known properties and functions, including Ras GTPase-activating protein activity, adenylyl cyclase modulation and microtubule binding, it is unclear which of these are essential for learning in mice and humans. Here we show that the learning deficits of Nf1(+/-) mice can be rescued by genetic and pharmacological manipulations that decrease Ras function. We also show that the Nf1(+/-) mice have increased GABA (gamma-amino butyric acid)-mediated inhibition and specific deficits in long-term potentiation, both of which can be reversed by decreasing Ras function. Our results indicate that the learning deficits associated with NF1 may be caused by excessive Ras activity, which leads to impairments in long-term potentiation caused by increased GABA-mediated inhibition. Our findings have implications for the development of treatments for learning deficits associated with NF1.     

矿石可选性预测专家系统(Ⅰ)─—系统的总体设计

建立了铅锌矿石可造性预测专家系统，运行结果良好。本篇着重论述矿石可造性领域知识的特点和知识表示方法；分析矿石可造性预测专家系统的主要特征；讨论矿石可造性预测子问题的划分、一般决策过程、推理控制策略以及系统的总体设计。     

A calcium sensor in the sodium channel modulates cardiac excitability.

Sodium channels are principal molecular determinants responsible for myocardial conduction and maintenance of the cardiac rhythm. Calcium ions (Ca2+) have a fundamental role in the coupling of cardiac myocyte excitation and contraction, yet mechanisms whereby intracellular Ca2+ may directly modulate Na channel function have yet to be identified. Here we show that calmodulin (CaM), a ubiquitous Ca2+-sensing protein, binds to the carboxy-terminal 'IQ' domain of the human cardiac Na channel (hH1) in a Ca2+-dependent manner. This binding interaction significantly enhances slow inactivation-a channel-gating process linked to life-threatening idiopathic ventricular arrhythmias. Mutations targeted to the IQ domain disrupted CaM binding and eliminated Ca2+/CaM-dependent slow inactivation, whereas the gating effects of Ca2+/CaM were restored by intracellular application of a peptide modelled after the IQ domain. A naturally occurring mutation (A1924T) in the IQ domain altered hH1 function in a manner characteristic of the Brugada arrhythmia syndrome, but at the same time inhibited slow inactivation induced by Ca2+/CaM, yielding a clinically benign (arrhythmia free) phenotype.     

高新技术开发区网络管理系统的设计

根据高新技术产业开发区的特点，提出了一系列有针对性的软、硬件设计。     

Microbial degradation of bitumen

Summary A blown bitumen Mexphalte R 90/40 with a high content of saturated hydrocarbons was degraded by several microorganisms to the same extent. In batch cultures ofSaccharomycopsis lipolytica, maximal biodegradation was estimated to be about 9% w/w, 3.2·10^–3 g/cm² and 3.1·10^–3 cm of degraded bitumen. The Mexphalte R 90/40 degradation rate was closely coupled to biofilm formation. The microbial activity concerned predominantly the oxidation of saturated hydrocarbons. A direct distillation bitumen 80/100 with a low content of saturated hydrocarbons and a high content of aromatic hydrocarbons and resins was more resistant to biodegradation.     

介质腔稳频MIC射电接收的研究

本文研究的是射电望远镜中的本机振荡源、混频器和前中放三部分的混合MIC,对高Q介质稳频的反射型与反馈型两种振荡器的综合方式,理论上作了重点分析探讨,并研制成带有DRO的MIC组件。     

层流液柱吸收法测定气体在液相中的扩散系数

采用射流吸收的简捷方法，通过测定由Ｓｈｏｕｔｈｗｅｌｌ型孔板所产生的截面速度均匀的层流喷射液柱所吸收的气体量，由渗透理论所导出的模型，可计算出一定温度、压力下的微溶气体在液相中的分子扩散系数Ｄ。在温度为３０～４５℃的范围，测试结果与文献值吻合良好．     

Statecharts for Distributed Product Data Management System Modelling

Product data management (PDM) has been accepted as an important tool for the manufacturing industries. In recent years, more and mor e researches have been conducted in the development of PDM. Their research area s include system design, integration of object-oriented technology, data distri bution, collaborative and distributed manufacturing working environment, secur ity, and web-based integration. However, there are limitations on their rese arches. In particular, they cannot cater for PDM in dis...     

汕头市API指数年变化规律及控制对策

对汕头市全年空气主要污染物指数年变化规律进行统计、分析 ,结果显示 :其年变化规律受季节及气象要素影响 ,可吸入颗粒物浓度偏高的主要原因与人群活动有较密切关系 .并提出相应的控制对策 :加强对机动车尾气的控制、工业污染源管理和做好垃圾有效处理、主干道定期洒水降尘及绿化固土等工作     

A New Local Search Algorithm for the Job Shop Scheduling Problem

0　IntroductionThejobshopschedulingproblemwithwhichwearecon cernedconsistsinschedulingasetofjobsonasetofma chinesfortheobjectiveofminimizingthemake span ,i.e .themaximumoftimeneededforfinishingalljobs,whichissubjecttotheconstrainsthateachjobhasafixedprocessingorderthroughthemachinesandeachmachinecanprocessatmostonejobatatime .ThisproblemisNP hardandevenisoneofthehardestcom binationaloptimizationproblems.Itiswellknownthatonlysmallsizeprobleminstancescanbesolvedwithinareasonablecomputa tionalti…