半刚性基层沥青路面非连续结构强迫振动声效

为了无损、快速地识别半刚性基层沥青路面的结构非连续状态,实现病害预警和预养护,对冲击作用下路面板体强迫振动机理及其振动噪声特征进行了分析,并对单自由度路面系统的强迫振动微分方程进行求解.研究表明:因土基沉降、低温施工、压实不足等原因,沥青路面将产生结构内部及层间非连续病害；而非连续状态下的板体强迫振动噪声特征对冲击加载...     

Optimum design of equivalent accelerated life testing plans based on proportional hazards-proportional odds model

The optimum design of equivalent accelerated life testing plan based on proportional hazards-proportional odds model using D-optimality is presented.The defined equivalent test plan is the test plan that has the same value of the determinant of Fisher information matrix.The equivalent test plan of step stress accelerated life testing(SSALT) to a baseline optimum constant stress accelerated life testing(CSALT) plan is obtained by adjusting the censoring time of SSALT and solving the optimization problem for each case to achieve the same value of the determinant of Fisher information matrix as in the baseline optimum CSALT plan.Numerical examples are given finally which demonstrate the equivalent SSALT plan to the baseline optimum CSALT plan reduces almost half of the test time while achieving approximately the same estimation errors of model parameters.     

浅谈高速公路施工中强夯路基监理

由于高速公路建设要求高、工期短、点多面广范围大,在施工中需要不断创新,运用新技术、新工艺成为必然。近年来,强夯路基技术在高速公路中广泛使用,并且取得了一定的效果。文章结合广东某高速公路强夯法的施工监理进行探讨。     

Enhanced mechanical properties of AZ31 magnesium alloy sheets by continuous bending process after V-bending

The effects of V-bending process, continuous bending process and combination process on the microstructure and mechanical properties and formability of an AZ31 magnesium alloy sheet were investigated. The experimental results showed that no twins were found in the microstructure of all samples after processes due to the fine grain. The V-bending and continuous bending processes were proved to be an effective approach to modify the mechanical properties and formability. While the samples after the combination process exhibited better mechanical properties and formability than the single processed sample. The yield strength significantly decreased with the value of 100 MPa and the fracture elongation enhanced to 18.3% at room temperature. The Erichsen value was 5.0 mm which was significantly increased by 117% compared with as-received sample. The superior formability of combination processed samples was mainly attributed to the smaller r-value and n-value.     

14-3-3sigma controls mitotic translation to facilitate cytokinesis

14-3-3 proteins are crucial in a wide variety of cellular responses including cell cycle progression, DNA damage checkpoints and apoptosis. One particular 14-3-3 isoform, sigma, is a p53-responsive gene, the function of which is frequently lost in human tumours, including breast and prostate cancers as a result of either hypermethylation of the 14-3-3sigma promoter or induction of an oestrogen-responsive ubiquitin ligase that specifically targets 14-3-3sigma for proteasomal degradation. Loss of 14-3-3sigma protein occurs not only within the tumours themselves but also in the surrounding pre-dysplastic tissue (so-called field cancerization), indicating that 14-3-3sigma might have an important tumour suppressor function that becomes lost early in the process of tumour evolution. The molecular basis for the tumour suppressor function of 14-3-3sigma is unknown. Here we report a previously unknown function for 14-3-3sigma as a regulator of mitotic translation through its direct mitosis-specific binding to a variety of translation/initiation factors, including eukaryotic initiation factor 4B in a stoichiometric manner. Cells lacking 14-3-3sigma, in marked contrast to normal cells, cannot suppress cap-dependent translation and do not stimulate cap-independent translation during and immediately after mitosis. This defective switch in the mechanism of translation results in reduced mitotic-specific expression of the endogenous internal ribosomal entry site (IRES)-dependent form of the cyclin-dependent kinase Cdk11 (p58 PITSLRE), leading to impaired cytokinesis, loss of Polo-like kinase-1 at the midbody, and the accumulation of binucleate cells. The aberrant mitotic phenotype of 14-3-3sigma-depleted cells can be rescued by forced expression of p58 PITSLRE or by extinguishing cap-dependent translation and increasing cap-independent translation during mitosis by using rapamycin. Our findings show how aberrant mitotic translation in the absence of 14-3-3sigma impairs mitotic exit to generate binucleate cells and provides a potential explanation of how 14-3-3sigma-deficient cells may progress on the path to aneuploidy and tumorigenesis.     

体质量对中华鳖(Pelodiscus sinensis)生化组成和质量能的影响

分别测定了在实验室条件下养殖的23只稚鳖(终末体质量为15.7～46.4 g)和38只幼鳖(终末体质量为57.5～283.7 g)鳖体的生化组成和质量能.结果表明:随着稚鳖、幼鳖体质量的增加,稚鳖和幼鳖鳖体的蛋白质、脂肪的质量分数和质量能均升高,而水分则随之降低(P＜0.01).稚鳖鳖体的灰分质量分数与体质量相关关系不明显(P＞0.05),而幼鳖的灰分质量分数随体质量增加而降低(P＜0.05).实验证实,以体质量为自变量来预测中华鳖稚鳖和幼鳖的蛋白质、脂肪的质量分数和质量能的方法是简单、可行的.     

Method to Realize TT&C of Spacecraft In-Orbit from Ground-Based to Space-Ground-Based Mode

Currently,TT&C of spacecraft is performed by a ground system．Because more and more spacecrafts are launched into orbits,it is difficult for the ground system to meet the TT&C requirements of the spacecrafts．To explore a new,effective and economical TT&C mode is absolutely necessary．A method is proposed to use SGBM mode in TT&C spacecrafts in low earth orbits,here．Firstly,the principle of the mode is discussed;secondly,the system to simulate the mode is designed;thirdly,the relative issues to use the mode are indicated;fourthly,the experimental results（simulation）to apply the mode to TT&C spacecrafts are analyzed;and finally dawn is the main conclusion of the method．     

解析工程的本质 ———兼论工程与科学技术的关系

工程是指运用特定的相关的工程科学、工程技术和管理原理,优化集成整合生产要素和资源,遵循 必要的程序、设计文件、规范、规程和标准,在一定的约束条件下对自然进行改造所实施的建设（包括决策、设 计、建造、评价）活动和过程,其最终成果是一个具备预定功能的“工程实体”。工程的本质就是各种利用和改 造自然的群体性活动方式的总和。工程的基本特征有集成性、群体性、动态性和合约性。工程与科学技术的 紧密关系反映了科学技术工程一体化,反映了工程与科学技术的融合、统一及互动作用。     

表面张力作用下柱形胶体的弹性失稳

采用弹性理论研究了圆柱形胶体在表面张力作用下的弹性失稳问题;利用能量泛函变分的方法导出 了发生弹性失稳的非经典边界条件,得到了失稳的判据方程。分析判据方程发现,弹性失稳与圆柱体的半径、 内禀尺度和失稳波长相关。