全粒子推动野马优化算法的无人机三维路径规划

针对无人机路径规划求解计算量大、难收敛等问题,提出了一种基于全粒子推动野马算法的路径规划方法。建立三维环境模型与路径代价模型,将路径规划问题转化为多维函数优化问题;采用一种自适应邻域搜索策略,改善算法的开发能力;利用高斯随机游走策略对个体的历史最优位置进行回溯搜索,改善算法的探索能力;考虑到自适应策略对初始种群多样性敏感的问题,结合Tent 混沌映射初始化种群,提高算法的鲁棒性以及全局寻优能力;将提出的改进算法在13个经典测试函数中进行性能验证,并移植于无人机三维路径规划问题中。在30峰、40峰、50峰的环境模型下进行测试,与遗传算法、粒子群算法、SRM-PSO(self-regulating and self-perception particle swarm optimization with mutation mechanism)算法以及野马算法对比,全粒子推动野马算法皆取得最短平均路径,且在所有测试中都找到满足约束、无碰的路径。仿真结果证明,在复杂环境下全粒子推动野马算法具有优秀的全局寻优能力以及较好的鲁棒性。     

Retinoic acid regulates avian lung branching through a molecular network

Retinoic acid (RA) is of major importance during vertebrate embryonic development and its levels need to be strictly regulated otherwise congenital malformations will develop. Through the action of specific nuclear receptors, named RAR/RXR, RA regulates the expression of genes that eventually influence proliferation and tissue patterning. RA has been described as crucial for different stages of mammalian lung morphogenesis, and as part of a complex molecular network that contributes to precise organogenesis; nonetheless, nothing is known about its role in avian lung development. The current report characterizes, for the first time, the expression pattern of RA signaling members (stra6, raldh2, raldh3, cyp26a1, rarα, and rarβ) and potential RA downstream targets (sox2, sox9, meis1, meis2, tgfβ2, and id2) by in situ hybridization. In the attempt of unveiling the role of RA in chick lung branching, in vitro lung explants were performed. Supplementation studies revealed that RA stimulates lung branching in a dose-dependent manner. Moreover, the expression levels of cyp26a1, sox2, sox9, rarβ, meis2, hoxb5, tgfβ2, id2, fgf10, fgfr2, and shh were evaluated after RA treatment to disclose a putative molecular network underlying RA effect. In situ hybridization analysis showed that RA is able to alter cyp26a1, sox9, tgfβ2, and id2 spatial distribution; to increase rarβ, meis2, and hoxb5 expression levels; and has a very modest effect on sox2, fgf10, fgfr2, and shh expression levels. Overall, these findings support a role for RA in the proximal–distal patterning and branching morphogenesis of the avian lung and reveal intricate molecular interactions that ultimately orchestrate branching morphogenesis.     

Beta-carotene affects gene expression in lungs of male and female <Emphasis Type="Italic">Bcmo1</Emphasis><Superscript>−/−</Superscript> mice in opposite directions

Molecular mechanisms triggered by high dietary beta-carotene (BC) intake in lung are largely unknown. We performed microarray gene expression analysis on lung tissue of BC supplemented beta-carotene 15,15′-monooxygenase 1 knockout (Bcmo1 ^−/−) mice, which are—like humans—able to accumulate BC. Our main observation was that the genes were regulated in an opposite direction in male and female Bcmo1 ^−/− mice by BC. The steroid biosynthetic pathway was overrepresented in BC-supplemented male Bcmo1 ^−/− mice. Testosterone levels were higher after BC supplementation only in Bcmo1 ^−/− mice, which had, unlike wild-type (Bcmo1 ^+/+) mice, large variations. We hypothesize that BC possibly affects hormone synthesis or metabolism. Since sex hormones influence lung cancer risk, these data might contribute to an explanation for the previously found increased lung cancer risk after BC supplementation (ATBC and CARET studies). Moreover, effects of BC may depend on the presence of frequent human BCMO1 polymorphisms, since these effects were not found in wild-type mice.     

PREPARATION AND MORPHOLOGY OF ISOTACTIC POLYPROPYLENE WITH HIGH CONTENT OF β CRYSTALLINE FORM

Isotactic polypropylene (iPP) with high content of ~ crystalline form was prepared by adding a series of new p form nucleators. The spherulites and morphology of//farm iPP (//-iPP) were investigated by wide-angle X-ray diffraction(WAXD), polarizing microscope (PLM), scanning electron microscope (SEM) and small-angle light scattering (SALS). WAXD experimental results indicate that the amount of p form in iPP (K_x) increases with increasing /~ nucleator content from zero to 0.07 wt% or crystallization temperature T_c from 20 to 120℃ and that the highest K_x value is up to 0.95. PLM observations suggest that p spherulites exhibit bright color and that their Maltese Crosses display some concentric banding of a rather spiky, jagged character. Their !amellae are smooth and relaxed layer-plate like structure by SEM and their SALS H_v patterns arc four-petalled.     

C~β(■)在C~α(■)(0<α<β<1)的非稠密性

下为Banacb空间.在偏微分方程的研究中,Holder空间是一类十分有用的函数空间。揭示Holder空间的性质无疑具有一定意义。众所周知,C~∞(Ω)在L′(Ω)、C~K(Ω)(K为正整数)稠密。但本工作将指出对C~n(Ω),C~∞(Ω)已不再是它的稠密子空间,更具体地说,将给出C~β(Ω)在C~n(Ω)(0<α<β<1)的闭子空间的特征,并证明它在C~n(Ω)不稠密。     

Downside Risk-Aversion Analysis for a Single-Stage Newsvendor Problem

We extend the classical newsvendor problem by introducing a downside risk constraint from the perspective of inventory control. At the beginning of a replenishment period the newsvendor will place an order, then he will review the inventory level at the end of the period. If the inventory level is positive then he will bear the holding cost and if the inventory level is negative then he will bear the backorder cost. The optimal order quantity has a simple form. We analyze the form of the optimal order quan-tity when we restrict that the probability that the cost level is larger than or equal to a fixed cost constant is less than a fixed value of probability. At last, we analyze the case that the fixed cost constant is equal to the expected cost.     

文献检索实习模式

获取文献信息的有效方法是学会文献检索，文献检索课是一门科学方法课，必须通过大量实习方能掌握文献检索原理与方法，为此，所使用的实习模式主要包括三个步骤，即对事实，数据性文献的检索，专类文献的检索以及专利文献的检索，通过实习能使学生牢固地掌握这门课的基本内容。