Chromosomal effects of adeno-associated virus vector integration.

Adeno-associated virus (AAV) vectors are currently being used in several clinical gene-therapy trials (see the NIH OBA Human Gene Transfer Clinical Trials Database); however, little is known about the chromosomal effects of vector integration. Here we report that integrated vector proviruses are associated with chromosomal deletions and other rearrangements and are frequently located on chromosome 19 (although not at the wildtype AAV integration site).     

一种基于距离和灰度的特征提取及其十字链表法的编程实现

本文从数字图像的灰度及其边缘的距离特征 ,对数字图像的特征提取进行了分析和探讨 ,并绘出了基于十字链表这种数据结构的编程实现方案     

曲棍球赛场技战术的计算机分析系统

介绍在ＩＢＭ－ＰＣ／ＸＴ计算机上实现的曲棍球赛场统计系统的研制过程、设计思想、采用的方法、软件设计与功能、技术指标操作步骤以及使用效果。     

Decision trees for forecasting

Recent years have seen an increasing cross-fertilization between the fields of decision analysis and forecasting. Decision-analytic models often require forecasts as inputs, and aspects of the Bayesian decision-theoretic framework underlying decision analysis have proved useful to forecasting, particularly in contexts where subjective judgemental inputs are required. This paper describes the use of decision tree analysis for forecasting and illustrates its use for corporate divisional forecasting and planning. A specialized decision-analytic technique, acts as events, is also described and illustrated to forecast a new product's earnings. Conclusions are drawn about the applicability of decision analysis for forecasting.     

Indoxyl derivatives of drug metabolites

Summary Indoxyl derivatives were detected as minor products among the urinary metabolites of two trial drugs, a benzodiazepine (GP 55 129) and a benzophenone (CGP 11 952). Their structures were elucidated by NMR and mass spectroscopy. Presumably, metabolites containing potential aldehyde functions react spontaneously with endogenous indoxyl. Such derivatives have not hitherto been encountered in drug metabolism.     

优化模型的改进计算方法

最优化模型与方法是近几十年来发展和形成的一门新兴的应用科学,通过应用数学的方法与技术解决各种系统与实际问题.但许多求解方法是基于手工运算,计算工作量较大.而利用各种优化计算软件例如Lingo,Lindo等需要编制较为复杂的程序,解决起来不够直观.而利用Matlab软件中非常直观的优化工具箱中的函数linprog,quadprog对线性规划与二次规划进行快速求解.     

阶段原型法及其支持环境

本文介绍了阶段原型法(SPA)及其支持环境(PEMIS)的总体结构和主要功能,探讨了知识库和推理机制在循环控制中的作用,以及软件重用技术、图形接口技术和应用生成技术等实现技术。     

管理审计的地位及应用

目前在企业审计工作中经常进行的、大量的是财务审计。审查财务活动的合法性,规范性,在管理审计方面开展得很少,这对审计理论及审计职能的研究和发挥无疑是不利的。本文将论述管理审计及其应用,以适应企业经济管理工作对审计的要求,充分发挥审计工作在企业经济活动中的作用。     

数据挖掘技术在银行业的应用

随着技术的进步、市场规模的扩大以及分工交易方式的发展,银行业的经营环境也因信息技术发展的影响而不断改变,银行业面临着愈加激烈的竞争.通过建立数据仓库,使用数据挖掘技术,挖掘出为银行创造利润的客户,从复杂的客户信息中建立模型,能够降低成本与风险,提高效益.     

Ruin Probability with Variable Premium Rate and Disturbed by Diffusion in a Markovian Environment

We consider a risk model with a premium rate which varies with the level of free reserves. In this model, the occurrence of claims is described by a Cox process with Markov intensity process, and the influence of stochastic factors is considered by adding a diffusion process. The integro-differential equation for the ruin probability is derived by a infinitesimal method.