Timed bromocriptine administration reduces body fat stores in obese subjects and hyperglycemia in type II diabetics.

Obese postmenopausal female volunteers were given timed daily oral dosages of bromocriptine, and tested for reduction of body fat stores. This dopamine agonist has been shown to reset circadian rhythms that are altered in obese animals and to reduce body fat levels in several animal models. The participants were instructed not to alter their existing exercise and eating behavior during treatment. Skinfold measurements were taken on 33 subjects as indices of body fat. The measurements (e.g., suprailiac) were reduced after six weeks by about 25%, which represents a reduction of 11.7% of the total body fat. These dramatic decreases in body fat, which are equivalent to that produced by severe caloric restriction, were accompanied by more modest reductions of body weight (2.5%), indicating a possible conservation of protein that is usually lost as a consequence of such caloric restriction. The effects of bromocriptine treatment on body fat and hyperglycemia were also examined in non-insulin dependent diabetics being treated with oral hypoglycemics (7 subjects) or insulin (7 subjects). Total body fat was reduced by 10.7% and 5.1% in diabetics on oral hypoglycemics and insulin, respectively, without any significant reductions in body weight. Hyperglycemia was reduced in most of the 15 diabetic subjects treated leading to euglycemia and even cessation of hypoglycemic drugs in 3 of the 7 subjects during 4-8 weeks of bromocriptine treatment. These findings support the hypothesis that obesity and type II diabetes may be treated effectively with bromocriptine when administered at the proper times and dosages.     

GCr15刀轴的断裂分析

本文对佳木斯市制药机械厂生产的制丸机刀轴在装机前出现断裂现象进行了分析,指出原热处理工艺中所采用的冷却介质不当是导致断裂的主要原因。     

Orlicz空间内单边K─泛函与平均模的等价性

本文在Ｏｒｌｉｃｚ空间内对周期函数建立了单边Ｋ─泛函与平均模的等价问题，对多元的情形也可以类似地得到．     

动力减振实验装置的结构设计与研制

介绍动力减振实验装置的结构、实验的方法、步验与数据处理。实验结果表明所采用的设计方法是合理的、可行的。     

光纤色散与OFDL信号处理

光纤色散对OFDL器件功能的影响并不总能忽略。对OFDL陷波器,在现有器件水平下,由于色散ND只能达到30dB左右,远低于测量系统的限制(>55dB)。利用陷波器,也可以测量光纤色散、该方法具有步骤简便、对器件要求低、精度高等优点。     

Short alanine-based peptides may form 3(10)-helices and not alpha-helices in aqueous solution.

Short alanine peptides, containing 16 or 17 residues, appear to form alpha-helices in aqueous solution. But the main spectroscopic analyses used on helical peptides (circular dichroism and nuclear magnetic resonance) cannot distinguish between an alpha-helix (in which the ith residue is hydrogen-bonded to residue i + 4; ref. 9) and the next most common peptide helix, the 3(10)-helix10 (i-->i + 3 hydrogen-bonding). To address this problem we have designed single and doubly spin-labelled analogues of alanine-based peptides in which the nitroxide spin label forms an unbranched side chain extending from the sulphur atom of a cysteine residue. Here we report the circular dichroism, Fourier-transform infrared and electron-spin resonance spectra of these peptides under helix-forming conditions. The infrared absorbance gives an amide I' band with a frequency that is substantially different from that observed for alpha-helices. The electron-spin resonance spectra of doubly labelled helices show that the ranking of distances between side chains, around a single turn (residues 4-8), is inconsistent with an alpha-helical structure. Our experiments suggest that the more likely peptide geometry is a 3(10)-helix.     

各种发热元件和取暖器的分析及比较

本文系统地分析和比较各种取暖器及其发热元件，这不仅有利于用户根据自己的需要选购恰当的取暖设备，更为改进和设计创新取暖器提供理论与实践的依据。     

蒸球球内温度分布及测量的研究

对蒸球球内温度分布进行了详细的分析，提出采用中通管测量球内温度并通过计算机对测量值进行校正的方法，实践说明了该方法效果良好，为采用Ｈ－因子数学模型控制蒸煮过程提供了更合理的手段。     

Statecharts for Distributed Product Data Management System Modelling

Product data management (PDM) has been accepted as an important tool for the manufacturing industries. In recent years, more and mor e researches have been conducted in the development of PDM. Their research area s include system design, integration of object-oriented technology, data distri bution, collaborative and distributed manufacturing working environment, secur ity, and web-based integration. However, there are limitations on their rese arches. In particular, they cannot cater for PDM in dis...