Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.     

基于NB-IoT技术的智能LED灯杆监控系统的研制

针对传统LED灯杆在远程监控、自动巡检、实时单灯调控、故障定位处理等方面存在的问题,本文提出基于窄带物联网(narrow band internet of things,NB-IoT)技术的智能LED灯杆监控系统的研制方案,采用STM32L151单片机作为主控芯片,控制多种传感器采集路灯信息,通过NB-IoT模块与核心...     

五味子有效成分保护心室重构的研究进展

五味子对心血管、免疫系统及CNS具有调节作用,阐述了五味子中有效成分木脂素和多糖保护心室重构的作用.     

Bidirectional Feedback Dynamic Particle Filter with Big Data for the Particle Degeneracy Problem

Particle Filter(PF) is a data assimilation method to solve recursive state estimation problem which does not depend on the assumption of Gaussian noise, and is able to be applied for various systems even with non-linear and non-Gaussian noise. However, while applying PF in dynamic systems, PF undergoes particle degeneracy,sample impoverishment, and problems of high computational complexity. Rapidly developing sensing technologies are providing highly convenient availability of real-time big traffic data from the system under study like never before. Moreover, some sensors can even receive control commands to adjust their monitoring parameters. To address these problems, a bidirectional dynamic data-driven improvement framework for PF(B3 DPF) is proposed.The B3 DPF enhances feedback between the simulation model and the big traffic data collected by the sensors,which means the execution strategies(sensor data management, parameters used in the weight computation,resampling) of B3 DPF can be optimized based on the simulation results and the types and dimensions of traffic data injected into B3 DPF can be adjusted dynamically. The first experiment indicates that the B3 DPF overcomes particle degeneracy and sample impoverishment problems and accurately estimates the state at a faster speed than the normal PF. More importantly, the new method has higher accuracy for multidimensional random systems.In the rest of experiments, the proposed framework is applied to estimate the traffic state on a real road network and obtains satisfactory results. More experiments can be designed to validate the universal properties of B3 DPF.     

A New Adaptive Formant Vocoder

A new type of vocoder system based upon formant analysis is presented in this paper. The LMS adaptive algorithm is used for tracking formants of speech signals. The results of computer simulation show that the new vocoder has better synthesized speech quality.     

阶段原型法及其支持环境

本文介绍了阶段原型法(SPA)及其支持环境(PEMIS)的总体结构和主要功能,探讨了知识库和推理机制在循环控制中的作用,以及软件重用技术、图形接口技术和应用生成技术等实现技术。     

我国污泥处理的现状及相关技术比较

城市污水处理所产生的污泥产量巨大而且成分复杂,如何避免二次污染并合理利用污泥中的有效成分,已经成为世界热点难题之一。文章介绍了我国城市污泥处理的现状,并对几种常规的污泥处理方法进行了比较,以便为污水处理厂进行污泥处理时提供依据。     

基于语言偏好的群体决策的软解法

群体决策模型用于支持系统或专家系统，面临的两个问题是：自然语言与机器语言的匹配以及模型解与决策者意向交融．本文在许多学者大量工作的基础上，试图提出群决策的软化求解模型．主要提出两方面的结果：一是多准则语言偏好的综合；二是采用模糊匹配方法和语言变量的软算法将个人语言偏好聚集为群体可接受决策解．最后给出实例计算以说明操作步骤．该模型可用于人－机交流式ＧＤＳＳ或小群（７～１２人）会议支持系统的软件设计     

容县基本农田划定与保护研究

摘要：分析了广西容县土地利用情况,包括耕地现状以及上级下达的土地利用总体规划确定的基本农田,划定前的基本农田的数量情况、质量情况和分布情况,划出划人情况,其中划出的基本农田包括不可调整的农用地、建设用地、坡度大于25°的耕地、不稳定耕地、土规预留范围内农保、零散分布图斑、零星达不到上图面积的村庄。     

UNIX操作系统初始化过程分析

本文作者曾对UNIX分时操作系统第六版和第七版的核心代码作过分析,尔后又对该系统的几个重要的外围程序和工具性程序做了解剖。UNIX初始化程序(包括init,getty和login)规模小、结构简单;但是,对初始化过程的深入了解,有助于理解系统活动的全过程,同时也是分析其他程序(如Shell)所不可缺少的准备。