维修“天窗”对电气化重载专线输送能力的影响

采用运行图模拟和理论分析相结合的方法,论证了电气化重载专线维修“天窗”的预留方式,并分析了各种“天窗”的预留方案对输送能力的影响.     

Green核积分方程迭代配置解的误差展开

本文讨论了Ｇｒｅｅｎ核积分方程的迭代配置方法，得到了迭代配置解的一个多项误差展开式。     

菲涅耳半波带法公式A_K=a_1/2±a_k/2中K值的范围

本文对在点光源照明情况下,用菲涅耳半波带法求考察点P合振幅的近似公式A_k=a_1/2±a_k/2中K值的适用范围进行了讨论,纠正了某些光学书籍中对K值范围加以限制的结论     

Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1-induced B-lymphoblastic leukemia but not chronic myeloid leukemia

The Abl kinase inhibitor imatinib mesylate is the preferred treatment for Philadelphia chromosome-positive (Ph(+)) chronic myeloid leukemia (CML) in chronic phase but is much less effective in CML blast crisis or Ph(+) B-cell acute lymphoblastic leukemia (B-ALL). Here, we show that Bcr-Abl activated the Src kinases Lyn, Hck and Fgr in B-lymphoid cells. BCR-ABL1 retrovirus-transduced marrow from mice lacking all three Src kinases efficiently induced CML but not B-ALL in recipients. The kinase inhibitor CGP76030 impaired the proliferation of B-lymphoid cells expressing Bcr-Abl in vitro and prolonged survival of mice with B-ALL but not CML. The combination of CGP76030 and imatinib was superior to imatinib alone in this regard. The biochemical target of CGP76030 in leukemia cells was Src kinases, not Bcr-Abl. These results implicate Src family kinases as therapeutic targets in Ph(+) B-ALL and suggest that simultaneous inhibition of Src and Bcr-Abl kinases may benefit individuals with Ph(+) acute leukemia.     

Mutations of PVRL1, encoding a cell-cell adhesion molecule/herpesvirus receptor, in cleft lip/palate-ectodermal dysplasia

Cleft lip, with or without cleft palate (CL/P), is one of the most common birth defects, occurring in 0.4 to 2.0 per 1,000 infants born alive. Approximately 70% of CL/P cases are non-syndromic (MIM 119530), but CL/P also occurs in many single-gene syndromes, each affecting a protein critical for orofacial development. Here we describe positional cloning of the gene responsible for an autosomal recessive CL/P-ectodermal dysplasia (ED) syndrome (CLPED1; previously ED4; ref. 2), which we identify as PVRL1, encoding nectin-1, an immunoglobulin (Ig)-related transmembrane cell-cell adhesion molecule that is part of the NAP cell adhesion system. Nectin-1 is also the principal cell surface receptor for alpha-herpesviruses (HveC; ref. 7), and the high frequency of CLPED1 on Margarita Island in the Caribbean Sea might result from resistance of heterozygotes to infection by these viruses.     

浅谈排球立体进攻战术理论及实践方法

从现代排球立体进攻战术的演变与发展入手,阐述了立体进攻战术的主要特点,提出了培养与实施立体进攻战术的主要方法。     

Two-dimensional simulation of Poiseuille-Rayleigh-Bénard flows in binary fluids with Soret effect

Poiseuille-Rayleigh-Bénard flows in binary fluids with Soret effect are directly simulated by a mixed finite element method. A temperature perturbation is used as an initial disturbed source for the basic parallel flows. The whole spatio-temporal evolution of the binary fluid flows is exhibited: initially only the disturbed mode with the wavenumber k=π is amplified while others are damped, and continuously the amplified mode grows further and the nonlinear effect becomes important; after a nonlinear evolution transition the flow system evolves finally into a periodic right traveling wave.     

电阻应变测量技术在压力容器检验中的应用

介绍了电阻应变测量技术的测试原理和测试方法，并结合化工企业对压力容器检验的技术要求，应用电阻应变测量技术对典型压力容器作出了应力分析和安全评定。     

WINDOWS应用程序中实现二维动画的SDK编程方法

介绍如何利用ＳＤＫ开发具有二维动画效果的ＷＩＮＤＯＷＳ应用程序．程序运行时，动画不断地进行变化，用户可以在生动活泼的环境下进行各项程序功能的操作．     

活性染料电化学氧化降解反应机理分析

电化学法是一种清洁处理方法,已广泛用于有机废水处理.印染行业是当前主要的排污行业,而活性染料废水又是印染废水的主要组成部分.研究以NaCl和Na2SO4作电解质,Pb/PbO2作阳极,分析电化学法降解活性染料的机理,提出“四阶段”降解过程机制.