中华鳖并发性寄生虫病的初步研究与防治

初步研究了中华鳖尾孢子病与钟形虫病并发症的发病症状,流行特点及其危害,并对该病的治疗措施进行了探讨。     

顶管施工技术

文章介绍了在地下敷设管线施工的一种无需开挖地面的新技术,对技术特点、工艺原理及相关计算作了介绍.     

索力调整中影响矩阵在MIDAS/CIVIL中的实现

本文以一座提篮式系杆拱桥为工程背景研究索力调整中影响矩阵在桥梁专业软件中的实现方法。采用桥梁专用有限元软件MIDAS/CIVIL建立全桥空间模型,模型中索单元用桁架单元模拟,详细列出了索力调整中影响矩阵求解过程。该方法快捷、方便,并且满足精度要求,对实际工程中的索力调整具有现实指导意义。     

A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis

To identify susceptibility loci for ankylosing spondylitis, we performed a two-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 1,356,350 autosomal SNPs in 1,837 individuals with ankylosing spondylitis and 4,231 controls; in the validation stage, we analyzed 30 suggestive SNPs in an additional 2,100 affected individuals and 3,496 controls. We identified two new susceptibility loci between EDIL3 and HAPLN1 at 5q14.3 (rs4552569; P = 8.77 × 10(-10)) and within ANO6 at 12q12 (rs17095830; P = 1.63 × 10(-8)). We also confirmed previously reported associations in Europeans within the major histocompatibility complex (MHC) region (top SNP, rs13202464; P < 5 × 10(-324)) and at 2p15 (rs10865331; P = 1.98 × 10(-8)). We show that rs13202464 within the MHC region mainly represents the risk effect of HLA-B*27 variants (including HLA-B*2704, HLA-B*2705 and HLA-B*2715) in Chinese. The two newly discovered loci implicate genes related to bone formation and cartilage development, suggesting their potential involvement in the etiology of ankylosing spondylitis.     

IFT54 regulates IFT20 stability but is not essential for tubulin transport during ciliogenesis

Intraflagellar transport (IFT) is required for ciliogenesis by ferrying ciliary components using IFT complexes as cargo adaptors. IFT54 is a component of the IFT-B complex and is also associated with cytoplasmic microtubules (MTs). Loss of IFT54 impairs cilia assembly as well as cytoplasmic MT dynamics. The N-terminal calponin homology (CH) domain of IFT54 interacts with tubulins/MTs and has been proposed to transport tubulin during ciliogenesis, whereas the C-terminal coiled-coil (CC) domain binds IFT20. However, the precise function of these domains in vivo is not well understood. We showed that in Chlamydomonas, loss of IFT54 completely blocks ciliogenesis but does not affect spindle formation and proper cell cycle progression, even though IFT54 interacts with mitotic MTs. Interestingly, IFT54 lacking the CH domain allows proper flagellar assembly. The CH domain is required for the association of IFT54 with the axoneme but not with mitotic MTs, and also regulates the flagellar import of IFT54 but not IFT81 and IFT46. The C-terminal CC domain is essential for IFT54 to bind IFT20, and for its recruitment to the basal body and incorporation into IFT complexes. Complete loss of IFT54 or the CC domain destabilizes IFT20. ift54 mutant cells expressing the CC domain alone rescue the stability of IFT20 and form stunted flagella with accumulation of both IFT-A component IFT43 and IFT-B component IFT46, indicating that IFT54 also functions in IFT turn-around at the flagellar tip.     

多相垂直管流压降梯度“奥氏”法计算程序

在自喷井、气举井的生产管理中,编制多相垂直管流压降梯度计算软件和备有一套压力曲线图板具有同等重要的应用价值。从精度上考虑,前者更显优越。 本文介绍目前公认较为精确的,区分流动型态的Orkiszewski计算油管压力分布和井底流压的方法所编成的程序。该程序首先判别各压力区间的流动型态,然后选用不同的混气液平均重度和摩擦压降公式来计算油管内的压降梯度,最后算出各压力区间的深度差。该程序采用迭代法解决了油管内温度分布的问题,从而取得较高的精度。本文还介绍了用分段抛物线插值法由计算机自动读取高压物线参数的程序,可提高运算速度和精度。     

竞争失效下多元退化建模的导弹贮存寿命评估

导弹失效是弹上多部件退化失效与突发失效相互竞争的结果。根据导弹失效模式分析,建立导弹竞争失效模型。针对贮存期内测试到的弹上多个关键部件特征电压数据,引入状态空间模型,将弹上多个关键部件的特征电压转化为整弹退化程度,采用Wiener、Gamma和Inverse-Gaussian等随机过程模型来拟合整弹退化程度数据,采用赤池信息准则来确定最优的随机过程模型。假定导弹突发失效时间服从Weibull分布,采用比例危险模型,建立了考虑性能退化影响的突发失效率函数。采用两步极大似然估计法求解出模型中未知参数。结合某批次导弹贮存案例分析,验证了本文所建模型的正确性和优势。     

生产现场定型管理模型——系统分析方法在企业管理中的应用

运用系统分析方法，研究了生产现场定型管理系统模型的设计、优化和应用。文中对定型管理的概念、系统模型结构和系统模型设计与应用原则、系统模型的评价分析、以及系统模型的优化进行了深入的阐述.     

基于多串口卡的Ad hoc网络仿真系统的设计与实现

Ad hoc网络是一种无中心的自组织网络，其多跳性和移动性使得很难在传统的局域网或有中心的移动网络中仿真和调试其协议和算法。首先分析了在传统局域网和移动网进行Ad hoc网络仿真的难点和问题所在，接着提出了基于MOXA Smartio CP-168U／PCI多串口卡的Ad hoc网络仿真方案，然后详细介绍了仿真系统的功能和系统主要模块在VC 6．0环境下的实现，最后对系统作出分析和评价。     

Efficient hybrid neural network for spike sorting

Artificial neural network has been used successfully to develope the automatic spike extraction. In order to address some of the problems before the wireless transmission of the implantable chip, the automatic spike sorting method with low complexity and high efficiency is proposed based on the hybrid neural network with the principal component analysis network (PCAN) and normal boundary response (NBR) self-organizing mapping (SOM) network classifier. An automatic PCAN technique is used to reduce the dimension and eliminate the correlation of the spike signal. The NBR-SOM network performs the spike sorting challenge and improves the classification performance. The experimental results show that based on the hybrid neural network, the spike sorting method achieves the accuracy above 97.91% with signals containing five classes. The proposed NBR-SOM network classifier is to further improve the stability and effectiveness of the classification system.