Studies on the metabolic fate of the14C-labeled methyl group of a methylhydrazine derivative in P815 mouse leukemia

Zusammenfassung Neben der bereits beschriebenen teilweisen Oxydation der endständigen N-Methylgruppe von 1-Methyl-¹⁴C-2-p-(isopropylcarbamoyl)benzylhydrazin-Hydrochlorid (MBH) (NSC 77213) in vivo⁵ lassen die hier aufgeführten Resultate auch auf eine Transmethylierung dieser Methylgruppe schliessen.     

Esterase alterations in neurological mutants of the mouse

Zusammenfassung In Analysen von Gehirn-Zymogrammen verschiedener neurologischer Mäusemutanten wurden Abnormalitäten in Form von Esterasedefiziten gefunden. Da solche neulich auch für die multiple Sklerose des Menschen beschrieben wurden, wird vorgeschlagen, unspezifische Esterasen als signifikant für den normalen Myelinanabolismus zu bewerten.

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This investigation was supported by Public Health Service research Grant CA 04691-06 from the National Cancer Institute.     

Tartrate-resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type I interferon expression signature

We studied ten individuals from eight families showing features consistent with the immuno-osseous dysplasia spondyloenchondrodysplasia. Of particular note was the diverse spectrum of autoimmune phenotypes observed in these individuals (cases), including systemic lupus erythematosus, Sj?gren's syndrome, hemolytic anemia, thrombocytopenia, hypothyroidism, inflammatory myositis, Raynaud's disease and vitiligo. Haplotype data indicated the disease gene to be on chromosome 19p13, and linkage analysis yielded a combined multipoint log(10) odds (LOD) score of 3.6. Sequencing of ACP5, encoding tartrate-resistant acid phosphatase, identified biallelic mutations in each of the cases studied, and in vivo testing confirmed a loss of expressed protein. All eight cases assayed showed elevated serum interferon alpha activity, and gene expression profiling in whole blood defined a type I interferon signature. Our findings reveal a previously unrecognized link between tartrate-resistant acid phosphatase activity and interferon metabolism and highlight the importance of type I interferon in the genesis of autoimmunity.     

Conventions for recreational problems in Fibonacci’s <Emphasis Type="Italic">Liber Abbaci</Emphasis>

Fibonacci’s treatment of so-called recreational problems in his Liber Abbaci has been interpreted as an early episode both in the history of systems of linear equations, and in the history of negative numbers. However, these problems are also interesting in their own right. We discuss some of the conventions which seem to have governed these problems. By considering certain pairs of problems, where one problem is unsolvable and its partner is solvable, we show that Fibonacci went to a significant effort to conform to these conventions. We also examine the methods which he could have used to construct his problems.     

A principal theorem of normal discretization schemes for operator equations of the first kind

The authors announce a newly-proved theorem of theirs. This theorem is of principal significance to numerical computation of operator equations of the first kind. Biography: Du Nai-lin (1962-), male, Ph. D, Associate professor, research interests: partial differential equations, ordinary differential equations, applied functional analysis.