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21.
Cellular turnover and extracellular matrix remodeling in female reproductive tissues: functions of metalloproteinases and their inhibitors 总被引:18,自引:0,他引:18
Fata JE Ho AT Leco KJ Moorehead RA Khokha R 《Cellular and molecular life sciences : CMLS》2000,57(1):77-95
Female reproductive tissues possess a unique ability to accommodate a remarkable amount of cell turnover and extracellular matrix (ECM) remodeling following puberty. Cellular structures within ovary, uterus, and mammary tissue not only change cyclically in response to ovarian hormones but also undergo differentiation during pregnancy, and eventually revert to that resembling the pre-pregnant stage. Cell proliferation, apoptosis, invasion, and differentiation are integral cellular processes that are precisely regulated in reproductive tissues, but become dysregulated in pathologies such as cancer. Explicit reorganization of ECM and basement membranes is also critical to preserve the form and function of these tissues. Here we review the evidence that coordinated spatiotemporal expression patterns of matrix metalloproteinase (MMP) genes and their tissue inhibitors (TIMPs) are important in cell and ECM turnover of the ovary, uterus, and mammary tissues. We discuss how perturbation in these gene families may impact the biology of these reproductive tissues and the factors implicated in the control of MMP and TIMP gene expression. The observed trends in MMP and TIMP expression involved in ovarian and mammary carcinomas are also presented. 相似文献
22.
Åsa Thureson-Klein Jen Wang-Yang I. K. Ho 《Cellular and molecular life sciences : CMLS》1978,34(6):773-774
Summary After morphine injection lipid accumulation in mouse hepatocytes begins within 2 h and continues for 24 h when most hepatocytes are filled with lipid droplets. In spite of morphine maintenance the liver recovers as the accumulated lipids are coupled with protein and subsequently transported and released into the perisinusoidal space of Disse.Supported by USPHS Grants GM 15490, 5 SO7 RR05386-16 and DA-01310. 相似文献
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Résumé La dihydrojasmone a été synthétisée en trois étapes à partir du pentanedione-2,4.
This research was supported by NRCC, Ottawa. 相似文献
This research was supported by NRCC, Ottawa. 相似文献
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Following oral or intravenous administration, a representative cognition activator drug, pramiracetam sulfate, is shown to have a pharmacologic therapeutic window at three different levels of study: learned behavior, gross EEG activity of the frontal cortex and hippocampus, and firing rate of single hippocampal neurons. 相似文献
27.
K. Wiesner Pak-Tsun Ho D. Chang J. F. Blount 《Cellular and molecular life sciences : CMLS》1972,28(10):766-767
Zusammenfassung Die Herstellung eines Schlüsselprodukts für die Synthese von Alkaloiden des Songorin- und Delphinin-Typs wird beschrieben.
We wish to thank the Hoffmann La Roche Company Inc., Nutley, New Jersey, and specifically Dr.A. Brossi, not only for financial support but also for collaboration and help. Financial support by the National Research Council of Canada is gratefully acknowledged. 相似文献
We wish to thank the Hoffmann La Roche Company Inc., Nutley, New Jersey, and specifically Dr.A. Brossi, not only for financial support but also for collaboration and help. Financial support by the National Research Council of Canada is gratefully acknowledged. 相似文献
28.
Eliane Namie Miyaji Maria Leonor Sarno Oliveira Eneas Carvalho Paulo Lee Ho 《Cellular and molecular life sciences : CMLS》2013,70(18):3303-3326
Streptococcus pneumoniae remains an important cause of disease with high mortality and morbidity, especially in children and in the elderly. The widespread use of the polysaccharide conjugate vaccines in some countries has led to a significant decrease in invasive disease caused by vaccine serotypes, but an increase in disease caused by non-vaccine serotypes has impacted on the overall efficacy of these vaccines on pneumococcal disease. The obvious solution to overcome such shortcomings would be the development of new formulations that provide serotype-independent immunity. This review focuses on the most promising approaches, including protein antigens, whole cell pneumococcal vaccines, and recombinant bacteria expressing pneumococcal antigens. The protective capacity of these vaccine candidates against the different stages of pneumococcal infection, including colonization, mucosal disease, and invasive disease in animal models is reviewed. Some of the human trials that have already been performed or that are currently ongoing are presented. Finally, the feasibility and the possible shortcomings of these candidates in relation to an ideal vaccine against pneumococcal infections are discussed. 相似文献
29.
The utility F-box for protein destruction 总被引:2,自引:1,他引:2
A signature feature of all living organisms is their utilization of proteins to construct molecular machineries that undertake the complex network of cellular activities. The abundance of a protein element is temporally and spatially regulated in two opposing aspects: de novo synthesis to manufacture the required amount of the protein, and destruction of the protein when it is in excess or no longer needed. One major route of protein destruction is coordinated by a set of conserved molecules, the F-box proteins, which promote ubiquitination in the ubiquitin-proteasome pathway. Here we discuss the functions of F-box proteins in several cellular scenarios including cell cycle progression, synapse formation, plant hormone responses, and the circadian clock. We particularly emphasize the mechanisms whereby F-box proteins recruit specific substrates and regulate their abundance in the context of SCF E3 ligases. For some exceptions, we also review how F-box proteins function through non-SCF mechanisms. 相似文献
30.
GAO Zhi-wei Ho Daniel W. C. WANG Xian-lai LI Guang-quan . Tianjin University Tianjin China . City University of Hong Kong Kowloon Hong Kong China 《系统科学与系统工程学报(英文版)》2000,(1)
1 IntroductionConsider a singular decentralized control system of the formEx(t) =Ax(t) ∑Ni=1Biui(t)yi =Cix(t) ,i∈ N ={ 1 ,2 ,… ,N}(1 )where x(t)∈ Rn is the state vector,ui(t)∈ Rmi and yi(t)∈ Rpi are respectively the localcontrol input and measure outputvectors of the ith control channel.The matrix E may besingular,i.e.,rank(E) 相似文献