CeO2包覆TiO2的XPS研究

利用光电子能谱ＸＰＳ研究ＣｅＯ２包覆ＴｉＯ２后氧化还原性能。ＴＥＭ照片证明实验中制备出包覆材料：Ｃｅ３ｄ谱线说明加入ＴｉＯ２后ＣｅＯ２非常容易还原,吸氧时它能够再氧化。     

Comparative FTIR spectroscopic analysis of human breast benign and malignant tissues

Some remarkable FTlR spectral differences are observed and the differences at the molecular level are extracted between benign and malignant breast tissue samples. For the malignant tissue, the relative content of nucleic acids is increased whereas the collagen is decreased. The proteins are phosphorylated and become more flexible and disordered. And these significant differences have important implications not only for probing the process of the breast lesion at the molecular level, but also for evaluating the histological types and grades of breast diseases.     

基于LSIBM-LES的浅水河岸水轮机尾流特性分析

设计了一种部分嵌入在浅水河岸侧壁上的新型阻力型垂直轴水轮机．这种水轮机在河流中层运行,可以有效适应流量、泥沙等多种环境因素的变化,且对鱼类等水生生物友好．为研究水轮机的性能及尾流特性,对其在明渠中的流动过程进行了大涡模拟(LES)．采用基于水平集函数的浸入边界法(LSIBM)分别描述了规则半圆柱形空腔及复杂水轮机的几何结构,并基于耦合水平集流体体积(CLSVOF)法捕捉不断变化的自由液面．将计算得到的不同叶尖速比下的水轮机功率系数与模型试验结果进行对比,验证了数值仿真结果的准确性．基于计算结果对雷诺应力进行了三重分解,结果显示水轮机近尾流区域的不稳定性与叶片通过频率密切相关．     

订单农业的履约博弈

针对订单农业履约难问题,在对一次性和无限重复履约博弈的策略分析基础上,结合违约成本和赔偿概率的分析,探讨如何提高订单农业的履约率.     

亚甲基蓝对水丝蚓的急性毒性

采用急性毒性实验方法测定了亚甲基蓝对水丝蚓的急性毒性.结果表明:亚甲基蓝对水丝蚓的24、48、72 h半致死浓度(LC50)分别为31.6,20.6,18.8 mg/L,作为核染色剂的亚甲基蓝溶液在一定浓度范围内对水丝蚓造成胁迫,影响动物正常行为以至危害生命.     

哈萨克族和汉族男性胰岛素抵抗相关因素与血压关系的对比分析

通过对哈萨克族与汉族男性胰岛素抵抗相关因素与血压的关系的对比,探讨可能存在的民族差异。抽取哈、汉民族男性共120人,采用直线相关分析分析各民族之间胰岛素抵抗相关因素与血压之间的关系。比较发现：哈、汉民族男性胰岛素抵抗指数、体重指数、腰臀比、三酰甘油、瘦素等因素均与血压正相关,未见种族差异;而哈族男性尿酸、总胆固醇与血压正相关,汉族男性尿酸、总胆固醇与血压不相关,存在种族差异。     

Mutations affecting components of the SWI/SNF complex cause Coffin-Siris syndrome

By exome sequencing, we found de novo SMARCB1 mutations in two of five individuals with typical Coffin-Siris syndrome (CSS), a rare autosomal dominant anomaly syndrome. As SMARCB1 encodes a subunit of the SWItch/Sucrose NonFermenting (SWI/SNF) complex, we screened 15 other genes encoding subunits of this complex in 23 individuals with CSS. Twenty affected individuals (87%) each had a germline mutation in one of six SWI/SNF subunit genes, including SMARCB1, SMARCA4, SMARCA2, SMARCE1, ARID1A and ARID1B.     

Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations

Pancreatic cancer has the lowest survival rate among human cancers, and there are no effective markers for its screening and early diagnosis. To identify genetic susceptibility markers for this cancer, we carried out a genome-wide association study on 981 individuals with pancreatic cancer (cases) and 1,991 cancer-free controls of Chinese descent using 666,141 autosomal SNPs. Promising associations were replicated in an additional 2,603 pancreatic cancer cases and 2,877 controls recruited from 25 hospitals in 16 provinces or cities in China. We identified five new susceptibility loci at chromosomes 21q21.3, 5p13.1, 21q22.3, 22q13.32 and 10q26.11 (P = 2.24 × 10(-13) to P = 4.18 × 10(-10)) in addition to 13q22.1 previously reported in populations of European ancestry. These results advance our understanding of the development of pancreatic cancer and highlight potential targets for the prevention or treatment of this cancer.     

Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations

Esophageal squamous-cell carcinoma (ESCC) is one of the most prevalent cancers worldwide and occurs at a relatively high frequency in China. To identify genetic susceptibility loci for ESCC, we conducted a genome-wide association study on 2,031 individuals with ESCC (cases) and 2,044 controls of Chinese descent using 666,141 autosomal SNPs. We evaluated promising associations in an additional 6,276 cases and 6,165 controls of Chinese descent from different areas of China. We identified seven susceptibility loci on chromosomes 5q11, 6p21, 10q23, 12q24 and 21q22 (ranging from P = 7.48 × 10(-12) to P = 2.44 × 10(-31)); among these loci, 5q11, 6p21 and 21q22 were newly identified. Three variants in high linkage disequilibrium on 12q24 confer their risks to ESCC in a gene-lifestyle interaction manner, with more pronounced risk enhancement seen in tobacco and alcohol users. Furthermore, the identified variants had a cumulative association with ESCC risk (P(trend) = 7.92 × 10(-56)). These findings highlight the involvement of multiple genetic loci and gene-environment interaction in the development of esophageal cancer.     

基于Jerk模型的单站无源定位跟踪算法研究

针对非线性较强的观测角、角度变化率、脉冲到达时间差等参数的单站无源定位跟踪系统,提出了一种新的跟踪滤波算法Jerk-UKF。该方法用Jerk模型对做复杂机动的运动目标建模,采用UKF滤波的思想对目标实现跟踪滤波。该算法可适用于对做多种机动运动的目标跟踪,提高了目标跟踪收敛精度和稳定性。仿真试验表明了该方法的可行性和有效性,并具有较高的应用价值。最后,对Jerk-UKF算法的研究方向进行了讨论。