全文获取类型
收费全文 | 223篇 |
免费 | 0篇 |
专业分类
系统科学 | 2篇 |
现状及发展 | 61篇 |
研究方法 | 27篇 |
综合类 | 132篇 |
自然研究 | 1篇 |
出版年
2018年 | 1篇 |
2016年 | 1篇 |
2013年 | 3篇 |
2012年 | 9篇 |
2011年 | 15篇 |
2010年 | 2篇 |
2008年 | 4篇 |
2007年 | 5篇 |
2006年 | 3篇 |
2005年 | 15篇 |
2004年 | 7篇 |
2003年 | 4篇 |
2002年 | 6篇 |
2001年 | 7篇 |
2000年 | 9篇 |
1999年 | 7篇 |
1996年 | 1篇 |
1992年 | 5篇 |
1991年 | 4篇 |
1990年 | 4篇 |
1989年 | 2篇 |
1987年 | 6篇 |
1986年 | 4篇 |
1985年 | 3篇 |
1984年 | 2篇 |
1983年 | 4篇 |
1982年 | 3篇 |
1981年 | 4篇 |
1980年 | 3篇 |
1979年 | 2篇 |
1978年 | 3篇 |
1977年 | 2篇 |
1976年 | 4篇 |
1975年 | 4篇 |
1974年 | 5篇 |
1973年 | 6篇 |
1972年 | 9篇 |
1971年 | 9篇 |
1970年 | 8篇 |
1969年 | 6篇 |
1968年 | 6篇 |
1967年 | 4篇 |
1966年 | 6篇 |
1965年 | 2篇 |
1959年 | 1篇 |
1958年 | 2篇 |
1957年 | 1篇 |
排序方式: 共有223条查询结果,搜索用时 15 毫秒
221.
Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors 总被引:25,自引:0,他引:25
Souslova V Cesare P Ding Y Akopian AN Stanfa L Suzuki R Carpenter K Dickenson A Boyce S Hill R Nebenuis-Oosthuizen D Smith AJ Kidd EJ Wood JN 《Nature》2000,407(6807):1015-1017
ATP activates damage-sensing neurons (nociceptors) and can evoke a sensation of pain. The ATP receptor P2X3 is selectively expressed by nociceptors and is one of seven ATP-gated, cation-selective ion channels. Here we demonstrate that ablation of the P2X3 gene results in the loss of rapidly desensitizing ATP-gated cation currents in dorsal root ganglion neurons, and that the responses of nodose ganglion neurons to ATP show altered kinetics and pharmacology resulting from the loss of expression of P2X(2/3) heteromultimers. Null mutants have normal sensorimotor function. Behavioural responses to noxious mechanical and thermal stimuli are also normal, although formalin-induced pain behaviour is reduced. In contrast, deletion of the P2X3 receptor causes enhanced thermal hyperalgesia in chronic inflammation. Notably, although dorsal-horn neuronal responses to mechanical and noxious heat application are normal, P2X3-null mice are unable to code the intensity of non-noxious 'warming' stimuli. 相似文献
222.
223.
Low European methyl chloroform emissions inferred from long-term atmospheric measurements 总被引:1,自引:0,他引:1
Reimann S Manning AJ Simmonds PG Cunnold DM Wang RH Li J McCulloch A Prinn RG Huang J Weiss RF Fraser PJ O'Doherty S Greally BR Stemmler K Hill M Folini D 《Nature》2005,433(7025):506-508
Methyl chloroform (CH3CCl3, 1,1,1,-trichloroethane) was used widely as a solvent before it was recognized to be an ozone-depleting substance and its phase-out was introduced under the Montreal Protocol. Subsequently, its atmospheric concentration has declined steadily and recent European methyl chloroform consumption and emissions were estimated to be less than 0.1 gigagrams per year. However, data from a short-term tropospheric measurement campaign (EXPORT) indicated that European methyl chloroform emissions could have been over 20 gigagrams in 2000 (ref. 6), almost doubling previously estimated global emissions. Such enhanced emissions would significantly affect results from the CH3CC13 method of deriving global abundances of hydroxyl radicals (OH) (refs 7-12)-the dominant reactive atmospheric chemical for removing trace gases related to air pollution, ozone depletion and the greenhouse effect. Here we use long-term, high-frequency data from Mace Head, Ireland and Jungfraujoch, Switzerland, to infer European methyl chloroform emissions. We find that European emission estimates declined from about 60 gigagrams per year in the mid-1990s to 0.3-1.4 and 1.9-3.4 gigagrams per year in 2000-03, based on Mace Head and Jungfraujoch data, respectively. Our European methyl chloroform emission estimates are therefore higher than calculated from consumption data, but are considerably lower than those derived from the EXPORT campaign in 2000 (ref. 6). 相似文献