Comparative dominant lethal studies with phenylbutazone,thio-TEPA and MMS in the mouse

Zusammenfassung Im Gegensatz zu Thio-TEPA (N, N, N-Triaethylen-thiophosphoramid) und MMS (Methansulfonsäuremethylester) führten i.p. Dosen von Phenylbutazon (50 und 100 mg/kg) bei der Maus, unter Berücksichtigung von post- und prae-implantativen Gestationsstadien, zu keinen genetischen Effekten im Sinne der Induktion von dominanten Letalfaktoren.     

Hypolipidaemic properties of a new tetralin derivative (CIBA 13,437-Su)

Zusammenfassung 2-Methyl-2-[p-(1,2,3,4-tetrahydro-1-naphthyl)-phenoxy]-propion-säure (CIBA 13,437-Su)stellt ein oral aktives Tetralin-Derivat dar, welches ausgeprägte Blutlipid-senkende Eigenschaften besitzt. Die hypolipidaemische Wirkung wurde bei mehreren Spezies untersucht und umfasste sowohl Cholesterin wie Glyzeride.     

Organtypische und phasenspezifische Verteilung ungesättigter Lipoide im Schwanz der Larve vonXenopus laevis

Summary Barrollier's method for unsaturated fatty acids (u. f. a.) in paper chromatograms has been adapted for cytochemical detection of u. f. a. in the tails ofXenopus-larvae. A specific pattern in the different organs was found. It was further shown that the content in u. f. a. changes quickly, apparently indicating rapid changes in physiological conditions during growth and regeneration.     

Proestrous gonadotropin levels in thyroparathyroidectomized female rats

Summary Intact and TPTx animals showed the expected afternoon increase in serum LH, FSH and prolactin levels. But the afternoon increase in serum LH levels in TPTx rats was less than that observed for intact animals (p<0.01). Neither serum prolactin nor FSH levels were altered by TPTx.The excellent technical and secretarial assistance ofS. Hemelt andD. Landman is gratefully acknowledged.     

Histidine phosphorylation and phosphoryl group transfer in bacterial chemotaxis

A cascade of protein phosphorylation, initiated by autophosphorylation of the CheA protein, may be important in the signal transduction pathway of bacterial chemotaxis. A proteolytic fragment of CheA cannot autophosphorylate, but can still transfer phosphate to proteins that generate excitation and adaptation signals. The site of CheA phosphorylation is His 48; mutants altered at this position are non-chemotactic. Similar mechanisms of transient protein phosphorylation and phosphoryl group transfer seem to be involved in processing sensory data and in activating specific gene expression.     

Transcription of bacterial DNA by isolated plant nuclei.

Plant nuclei prepared from protoplasts can be used as a cell-free system for testing their template activity of procaryotic DNA for plant polymerases. We were able to demonstrate that plant polymerases of Petunia hybrida are capable of transcribing linear bacterial DNA, whereas supercoiled DNA could not be used as a template.     

The lipid composition of frog retinal rod outer segments

Résumé Les lipides des segments extérieures des bâtonnets de la rétine de la grenouille sont principalement composés de phospholipides (66%), glycolipides (23%) et cholestérol (4%). Le phosphatidyle choline, le phosphatidyle éthanolamine et le phosphatidyle sérine constituent le 84% des phospholipides. Les résultats ne s'accordent pas avec le concept qu'un rapport élevé du cholestérol aux phospholipides caractérise les membranes du plasma et leurs dérivés.

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Supported by National Science Foundation Grant No. GB 3128 and United States Public Health Service Grant No. NB-130 from the National Institute of Neurological Diseases and Blindness.