日粮蛋白质水平对鹅生长性能及肉质的影响

选取28日龄、体重相近的合浦灰鹅60只,随机分为3个组,采用精料 青料(黑麦草等)混合的方式进行饲喂试验,试验期为42天。第70d采血测定血清中尿素氮、转氨酶活性、血脂和脂蛋白等生化指标,并进行屠宰测定和肌肉营养成分含量测定。试验结果表明:(1)生长前期(28~49日龄),第2组日增重较高,各组间差异不显著(P>0.05);生长后期(50~70日龄)第1组日增重较高,各组间差异不显著(P>0.05)。(2)鹅的血清尿素氮含量随饲粮粗蛋白质水平的降低而下降(P<0.05);血清转氨酶活性、脂类和脂蛋白含量等组间无显著差异。(3)饲粮粗蛋白质水平对肉鹅屠宰性能无显著影响,鹅肉中的干物质、粗蛋白质、氨基酸总量、必需氨基酸总量、肌内脂肪、肌苷酸含量与蛋白质有正相关,各组间差异不显著(P>0.05),随着蛋白质水平提高,肌肉的营养和风味有改善的趋势。     

预氯胺化处理受污染水源水的试验

对于高氨氮的受污染水源水的预处理国内大部分水厂通常采用预氯化工艺.以某市受污染水源水为研究对象,通过烧杯试验探讨了氯胺的预氧化助凝效能。结果表明,同无预氯胺化相比,氯胺在低投加量(2.0 mg/L)时,可明显降低水样的滤后浊度和沉后浊度,并且氯胺的助凝效能随氯、氮比率的增加而增强.     

氧化铝熟料烧结回转窑智能控制系统设计与应用

介绍了氧化铝熟料烧结回转窑的工艺生产过程。针对生产过程存在的大滞后、非线性和多变量强耦合等特点,提出了基于自适应模糊控制、软开关控制、自适应预测控制和传统回路控制相结合的智能控制策略,并基于此策略在计算机集散控制系统上开发了氧化铝熟料烧结回转窑智能控制软件,成功应用于某公司氧化铝熟料烧结回转窑,实现了氧化铝熟料烧结回转窑的稳定控制。该系统投运以来可靠性高,控制效果及时、准确,具有在冶金、水泥等行业推广的价值。     

一维质量矩控制系统建模与试验

为了大惯性质量控制系统硬件在环仿真的需要,研制了一种新型的控制系统试验装置。采用实测试验数据与M atlab仿真协同分析方法,完成了系统关键模块的试验建模。目前该试验系统在3°角度范围内,在受扰状态下能够自动平衡空间姿态。试验结果表明:该系统具有适于大惯性质量对象的硬件在环仿真的特点。     

吲哚啉螺吡喃化合物的合成及光致变色性质研究

合成了6-硝基-1,′3,′3′-三甲基吲哚啉螺苯并吡喃,通过红外光谱和元素分析确证其结构,并研究了闭环体与开环体的光致变色性能,解释了在不同溶剂介质中紫外吸收光谱的溶剂效应,并比较褪色反应速率常数的差异.     

一类特殊的有限p-群

探讨了一类特殊的有限p -群,即对任意x,y∈G,如果[x,y]≠1,那么《x,y》(△)-G.主要证明了:如果满足这样条件的有限p -群G＝《x1,x2,…,xn》,其中对任意x∈G,《x》G是交换群或者内交换群.     

一种病人可控的电子病历安全访问方案

部分病人对其电子病历访问有全程管控的特殊需求,而现有云环境下的电子病历共享系统却无法满足这一需求,于是提出了一种基于超级账本和星际文件系统的电子病历安全访问方案HyperEHR.该方案设计了由病历请求者所在机构以及病人双重审核且由病人决定病历最终访问权的方法.为保证跨机构之间的医疗数据安全互访,将病历生成、更新以及访问等信息存储在联盟链区块中,而将各医院、诊所产生的具体病历信息和访问控制策略加密存储在云端星际文件系统中.系统实现及分析表明：该方案有较好的可扩展性、互操作性及安全性,可满足病人对其医疗数据访问的管控,有效防止病历隐私泄露.     

Extremely low-coverage sequencing and imputation increases power for genome-wide association studies

Genome-wide association studies (GWAS) have proven to be a powerful method to identify common genetic variants contributing to susceptibility to common diseases. Here, we show that extremely low-coverage sequencing (0.1-0.5×) captures almost as much of the common (>5%) and low-frequency (1-5%) variation across the genome as SNP arrays. As an empirical demonstration, we show that genome-wide SNP genotypes can be inferred at a mean r(2) of 0.71 using off-target data (0.24× average coverage) in a whole-exome study of 909 samples. Using both simulated and real exome-sequencing data sets, we show that association statistics obtained using extremely low-coverage sequencing data attain similar P values at known associated variants as data from genotyping arrays, without an excess of false positives. Within the context of reductions in sample preparation and sequencing costs, funds invested in extremely low-coverage sequencing can yield several times the effective sample size of GWAS based on SNP array data and a commensurate increase in statistical power.     

Exome sequencing of liver fluke-associated cholangiocarcinoma

Opisthorchis viverrini-related cholangiocarcinoma (CCA), a fatal bile duct cancer, is a major public health concern in areas endemic for this parasite. We report here whole-exome sequencing of eight O. viverrini-related tumors and matched normal tissue. We identified and validated 206 somatic mutations in 187 genes using Sanger sequencing and selected 15 genes for mutation prevalence screening in an additional 46 individuals with CCA (cases). In addition to the known cancer-related genes TP53 (mutated in 44.4% of cases), KRAS (16.7%) and SMAD4 (16.7%), we identified somatic mutations in 10 newly implicated genes in 14.8-3.7% of cases. These included inactivating mutations in MLL3 (in 14.8% of cases), ROBO2 (9.3%), RNF43 (9.3%) and PEG3 (5.6%), and activating mutations in the GNAS oncogene (9.3%). These genes have functions that can be broadly grouped into three biological classes: (i) deactivation of histone modifiers, (ii) activation of G protein signaling and (iii) loss of genome stability. This study provides insight into the mutational landscape contributing to O. viverrini-related CCA.