N-烷基-O-烷基-O-(1,2,2,2-四氯乙基)硫代磷酰胺酯的合成研究

合成了9个未见文献报导的四氯乙基硫代磷酰胺酯,并对它们的合成、结构和性质以及杀蚜虫、线虫活性等进行了初步研究。     

Retrograde transport of endocytosed Shiga toxin to the endoplasmic reticulum.

Shiga toxin and some other protein toxins that act on targets in the cytosol have previously been shown to enter the trans-Golgi network. Transport by this route may be necessary for translocation of the toxin to the cytosol and for intoxication, but it is not known whether the enzymatically active part of the toxins actually enters the cytosol from the trans-Golgi network. It has been suggested that such toxins are transported in a retrograde manner to the endoplasmic reticulum and that translocation occurs in this organelle, but retrograde transport of endocytosed material beyond the trans-Golgi network has never been demonstrated. Here we show that in butyric acid-treated A431 cells endocytosed Shiga toxin is not only transported to the trans-Golgi network, but also to all Golgi stacks, to the endoplasmic reticulum and to the nuclear envelope. Furthermore, butyric acid sensitizes the cells to Shiga toxin, which is consistent with the possibility that retrograde transport is required for translocation of the toxin to the cytosol.     

系统聚类分析在农村消费水平划分中的应用

中国的经济发展主要存在着“东部”与“西部”的差距，文章利用聚类分析对我国部分省、市、自治区共28个样本进行分类，并加以分析．     

对河南农村劳动力向小城镇转移趋势的调查研究

“人口城镇化”是社会发展的必然趋势。本文从河南沁阳等九个“小城镇”的实际调查材料出发,较详细地讨论了农村劳动力向小城镇转移的流量,形成、就业层次和社会影响,说明中国的“人口城镇化”方向关键在于积极发展小城镇。