A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis

To identify susceptibility loci for ankylosing spondylitis, we performed a two-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 1,356,350 autosomal SNPs in 1,837 individuals with ankylosing spondylitis and 4,231 controls; in the validation stage, we analyzed 30 suggestive SNPs in an additional 2,100 affected individuals and 3,496 controls. We identified two new susceptibility loci between EDIL3 and HAPLN1 at 5q14.3 (rs4552569; P = 8.77 × 10(-10)) and within ANO6 at 12q12 (rs17095830; P = 1.63 × 10(-8)). We also confirmed previously reported associations in Europeans within the major histocompatibility complex (MHC) region (top SNP, rs13202464; P < 5 × 10(-324)) and at 2p15 (rs10865331; P = 1.98 × 10(-8)). We show that rs13202464 within the MHC region mainly represents the risk effect of HLA-B*27 variants (including HLA-B*2704, HLA-B*2705 and HLA-B*2715) in Chinese. The two newly discovered loci implicate genes related to bone formation and cartilage development, suggesting their potential involvement in the etiology of ankylosing spondylitis.     

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.     

Fixed Point Theorems for φ-Probabilistic Contraction in Hausdorff Fuzzy Metric Spaces

In this paper,we discuss the common fixed point with respect to several self-mappings on fuzzy metric space.Recently many authors put forward some relevant comm...     

五味子有效成分保护心室重构的研究进展

五味子对心血管、免疫系统及CNS具有调节作用,阐述了五味子中有效成分木脂素和多糖保护心室重构的作用.     

A New Adaptive Formant Vocoder

A new type of vocoder system based upon formant analysis is presented in this paper. The LMS adaptive algorithm is used for tracking formants of speech signals. The results of computer simulation show that the new vocoder has better synthesized speech quality.     

炼油厂废水处理污泥热解制油技术研究

对炼油厂废水处理污泥进行了催化热解产油实验,考察了温度（170－300℃）和反应时间（0－90min)对产油率的影响。温度越高,产油率越高,在300℃时,产油率达54．6％,经60min反应接近平衡。讨论了系统质量与能量平衡。     

祛寒逐风合剂治 疗尢 王痹(类风湿性关节炎)的研究

祛寒逐风合剂是以1972年由甘肃武威出土的汉代医简中“伤寒逐风方”为基础方配制而成的中药制剂,供临床使用。方中有制附片、川椒、细辛、白术、川芎、制鳖甲等,以温经散寒为主,佐以祛风除湿、活血止痛、补益肝肾,尊《黄帝内经》中“寒者热之”、“治寒以热”之大法,主要用于治疗wang痹（类风湿性关节炎）之辩证为风寒湿阻者。几年来临床观察120例,其中治愈23例,好转95例,临床验证取得了满意疗效,与宝光牌风湿液治病该病作对照,其疗效结果经统计学处理,治疗组优于对照组（P＜0．01）,且该药对中医辩证为风寒湿阻之各种痹证,包括西医诊断之风湿性关节炎、类风湿性关节炎、强直性脊柱炎、增生性关节炎、各种腰腿痛等都有很好的疗效,有望成为治疗风湿病的一种有效药物。     

武汉市"十一五"规划战略环境评价实践

以武汉市"十一五"规划战略环境评价为例,探讨了我国城市国民经济和社会发展规划战略环境评价的技术路线、指标体系与评价方法.研究表明,对城市空间布局、产业布局、产业结构以及城市交通的环境适宜性进行综合评价是这类规划战略环境评价的重要特征;互动式的评价模式能使环境因素及时、有效地纳入到决策过程中;指标体系是预测评价的基础,指标的选择除考虑科学性、代表性外还应强调可获得性、可量化性及可考核性.     

剪切闸板防喷器剪切性能评价

剪切闸板防喷器是井控设备的重要组成部分之一,其作用是在钻井过程中遇到突发情况时及时剪断钻杆并密封井口,其剪切性能直接关系到钻井作业的安全.以某新型上直下V结构的剪切闸板防喷器为研究对象,通过显示动力学模块对剪切闸板剪切钻杆的过程进行数值仿真模拟,分析研究闸板的剪切性能.并用该剪切闸板分别剪切5 in和5.5 in两种不...     

基于矩阵分析的橡胶透水混凝土正交试验

选取水胶比、橡胶粒径、橡胶掺量、VAE-707乳液掺量及目标孔隙率五个因素对橡胶透水混凝土进行正交试验设计,研究其对抗压、抗折强度及透水性能的影响。利用矩阵分析法和灰色决策进行分析,得到橡胶透水混凝土最优配合比:水胶比0.3、橡胶颗粒大小0.425 mm、橡胶颗粒掺量3%、VAE-707乳液掺量为6%、目标孔隙率为16%;其中目标孔隙率对透水混凝土的性能贡献率最大,透水混凝土的抗压、抗折强度随着目标孔隙率的升高而降低,而透水系数则呈相反规律;透水混凝土实测孔隙率整体小于设计孔隙率,有效孔隙率约占总孔隙率的80%～90%,封闭孔占总孔隙10%～20%左右。