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11.
Fox DW Yost S Kulkarni SR Torii K Kato T Yamaoka H Sako M Harrison FA Sari R Price PA Berger E Soderberg AM Djorgovski SG Barth AJ Pravdo SH Frail DA Gal-Yam A Lipkin Y Mauch T Harrison C Buttery H 《Nature》2003,422(6929):284-286
Observations of the long-lived emission--or 'afterglow'--of long-duration gamma-ray bursts place them at cosmological distances, but the origin of these energetic explosions remains a mystery. Observations of optical emission contemporaneous with the burst of gamma-rays should provide insight into the details of the explosion, as well as into the structure of the surrounding environment. One bright optical flash was detected during a burst, but other efforts have produced negative results. Here we report the discovery of the optical counterpart of GRB021004 only 193 seconds after the event. The initial decline is unexpectedly slow and requires varying energy content in the gamma-ray burst blastwave over the course of the first hour. Further analysis of the X-ray and optical afterglow suggests additional energy variations over the first few days. 相似文献
12.
Price PA Fox DW Kulkarni SR Peterson BA Schmidt BP Soderberg AM Yost SA Berger E Djorgovski SG Frail DA Harrison FA Sari R Blain AW Chapman SC 《Nature》2003,423(6942):844-847
Past studies of cosmological gamma-ray bursts (GRBs) have been hampered by their extreme distances, resulting in faint afterglows. A nearby GRB could potentially shed much light on the origin of these events, but GRBs with a redshift z 相似文献
13.
Bishop CE Whitworth DJ Qin Y Agoulnik AI Agoulnik IU Harrison WR Behringer RR Overbeek PA 《Nature genetics》2000,26(4):490-494
In most mammals, male development is triggered by the transient expression of the Y-chromosome gene, Sry, which initiates a cascade of gene interactions ultimately leading to the formation of a testis from the indifferent fetal gonad. Several genes, in particular Sox9, have a crucial role in this pathway. Despite this, the direct downstream targets of Sry and the nature of the pathway itself remain to be clearly established. We report here a new dominant insertional mutation, Odsex (Ods), in which XX mice carrying a 150-kb deletion (approximately 1 Mb upstream of Sox9) develop as sterile XX males lacking Sry. During embryogenesis, wild-type XX fetal gonads downregulate Sox9 expression, whereas XY and XX Ods/+ fetal gonads upregulate and maintain its expression. We propose that Ods has removed a long-range, gonad-specific regulatory element that mediates the repression of Sox9 expression in XX fetal gonads. This repression would normally be antagonized by Sry protein in XY embryos. Our data are consistent with Sox9 being a direct downstream target of Sry and provide genetic evidence to support a general repressor model of sex determination in mammals. 相似文献
14.
Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains. 总被引:72,自引:0,他引:72
J H Wang Y W Yan T P Garrett J H Liu D W Rodgers R L Garlick G E Tarr Y Husain E L Reinherz S C Harrison 《Nature》1990,348(6300):411-418
The structure of an N-terminal fragment of CD4 has been determined to 2.4 A resolution. It has two tightly abutting domains connected by a continuous beta strand. Both have the immunoglobulin fold, but domain 2 has a truncated beta barrel and a non-standard disulphide bond. The binding sites for monoclonal antibodies, class II major histocompatibility complex molecules, and human immunodeficiency virus gp120 can be mapped on the molecular surface. 相似文献
15.
Ageing, fitness and neurocognitive function. 总被引:18,自引:0,他引:18
A F Kramer S Hahn N J Cohen M T Banich E McAuley C R Harrison J Chason E Vakil L Bardell R A Boileau A Colcombe 《Nature》1999,400(6743):418-419
16.
Success in forecasting using mathematical/statistical models requires that the models be open to intervention by the user. In practice, a model is only one component of a forecasting system, which also includes the users/forecasters as integral components. Interaction between the user and the model is necessary to adequately cater for events and changes that go beyond the existing form of the model. In this paper we consider Bayesian forecasting models open to interventions, of essentially any form, to incorporate subjective information made available to the user. We discuss principles of intervention and derive theoretical results that provide the means to formally incorporate feedforward interventions into Bayesian models. Two example time series are considered to illustrate why and when such interventions may be necessary to sustain predictive performance. 相似文献
17.
Protein phosphorylation in the pancreatic B-cell 总被引:2,自引:0,他引:2
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Biosynthesis of ferritin molecules 总被引:2,自引:0,他引:2