Contractile response of halothane-depressed isolated atria to pyruvate

Zusammenfassung Die nach Halothan eingetretene Verminderung der Kontraktilität des Myokards kann durch Pyruvat verhindert werden. Dieses Ergebnis stützt die Hypothese. Halothan behindere die Aufnahme oder die Verwertung von Glycose.     

Mutations in a new member of the chromodomain gene family cause CHARGE syndrome

CHARGE syndrome is a common cause of congenital anomalies affecting several tissues in a nonrandom fashion. We report a 2.3-Mb de novo overlapping microdeletion on chromosome 8q12 identified by array comparative genomic hybridization in two individuals with CHARGE syndrome. Sequence analysis of genes located in this region detected mutations in the gene CHD7 in 10 of 17 individuals with CHARGE syndrome without microdeletions, accounting for the disease in most affected individuals.     

A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy

Stargardt-like macular dystrophy (STGD3, MIM 600110) and autosomal dominant macular dystrophy (adMD) are inherited forms of macular degeneration characterized by decreased visual acuity, macular atrophy and extensive fundus flecks. Genetic mapping data suggest that mutations in a single gene may be responsible for both conditions, already known to bear clinical resemblance. Here we limit the minimum genetic region for STGD3 and adMD to a 0.6-cM interval by recombination breakpoint mapping and identify a single 5-bp deletion within the protein-coding region of a new retinal photoreceptor-specific gene, ELOVL4, in all affected members of STGD3 and adMD families. Bioinformatic analysis of ELOVL4 revealed that it has homology to a group of yeast proteins that function in the biosynthesis of very long chain fatty acids. Our results are therefore the first to implicate the biosynthesis of fatty acids in the pathogenesis of inherited macular degeneration.     

超稳Y-沸石催化合成乙酰乙酸乙酯缩酮

用脱铝超稳Ｙ－沸石作催化剂合成了乙酰乙酸乙酯与乙二醇缩酮和丙二醇缩酮,其产率可达到８０％和９６％,考察了催化剂组成和反应时间对反应的影响规律,发现产物比反应物更易在催化剂表面吸附,对反应机理作了讨论。     

含镓层柱材料在β-甲基萘歧化反应中的催化行为

制备并表征了含镓层柱材料，考察了氧化铝和氧化镓交联皂石对β－甲基萘歧化反应的催化行为．结果表明：β－甲基萘以异构化反应为主．活性与酸量、选择性与酸性有很好的对应关系．氧化铝交联镓皂石较氧化钦交镓联皂石的活性高，歧化选择性亦高而异构选择性低．     

弱L-余拓扑空间的O_s-r连通性

利用弱r闭包引入弱L-余拓扑空间的Os-r连通性概念,研究了它的若干性质,证明了它是L-好的推广.     

中国绳蚋一新种(双翅目:蚋科)(英文)

本文记述采自贵州省雷公山自然保护区的绳蚋一新种 ,即苗岭蚋 Simulium(Gomphostilbia) miaolingense sp.nov.该新种具有雄虫后足基跗节膨胀和蛹茧无前中突等合并特征 ,且其两性尾器构造特殊 ,包括雄性生殖腹板基侧突 ,中骨短宽 ;雌性生殖板肉缘分离而外展 ,生殖义突两后臂具骨化小侧突 ,可与其它近缘种相区别。模式标本存放于贵阳医学院。